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Antioxidant and antimicrobial activity of a new generation phyto-gel

Antioksidativna i antimikrobna aktivnost fitogela novije generacije

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2015
2313.pdf (618.8Kb)
Authors
Cvetković, Dragan J.
Stanojević, Ljiljana P.
Kundaković, Tatjana
Zlatković, Saša Ž.
Nikolić, Goran
Article (Published version)
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Abstract
Antioxidant and antimicrobial activities of a new phyto-gel were studied in this work. The formulated gel is composed of propilene glycol extracts of St. John's worth (H. perforatum L.), comfrey (S. officinale L.), yarrow (A. millefolium L.), horsetail (E. arvense L.) and Na-usniate. The antioxidant activity was determined for the gel and each investigated extract of the gel separately by the DPPH test. The total phenols and flavonoids content was determined spectrophotometrically, for the gel and each investigated extracts. The antimicrobial activity of the gel and each compound separately was tested in vitro on the following microorganisms: Staphylococcus aureus, Micrococcus luteus, Bacillus subtilis, Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa, Candida albicans and Aspergillus niger. The antioxidant activity of the investigated samples decreases in the series: H. perforatum (EC50 = 1.04 mg/mL) > Na-usniate (EC50 = 4.16 mg/mL) > A. millefolium (EC50 = 7.60 mg/mL) ...> gel (EC50 = 23.47 mg/mL) > S. officinale (EC50 = 30.10 mg/mL) > E. arvense (EC50 = 44.70 mg/mL). The formulated phyto-gel showed the antimicrobial activity. The results suggest that the obtained phyto-gel is a good source of natural antioxidants and antimicrobial agents, and it has potential as an alternative to synthetic products in pharmaceutical and cosmetic industries.

U radu je ispitivana antioksidativna i antimikrobna aktivnost fitogela - formulacija gela sa propilen-glikolnim ekstraktima H. perforatum, S. officinale, A. millefolium, E. arvense i Na-usninatom. Primenom DPPH testa određena je antioksidativna aktivnost svih ispitivanih ekstrakata, Na-usninata i gela. Primenom spektrofotometrijskih metoda određen je sadržaj ukupnih fenola i flavonoida u ekstraktima i formulisanom gelu. Antimikrobna aktivnost gela, kao i njegovih pojedinačnih komponenata, je ispitivana in vitro na sledećim mikroorganizmima: Staphylococcus aureus, Micrococcus luteus, Bacillus subtilis, Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa, Candida albicans i Aspergillus niger. Antioksidativna aktivnost ispitivanih uzoraka opada u nizu: H. perforatum (EC50=1,04 mg/ml) > Na-usnate (EC50=4,16 mg/ml) > A. millefolium (EC50=7,60 mg/ml) > gel (EC50=23,47 mg/ml) > S. officinale (EC50=30,10 mg/ml) > E. arvense (EC50 44,70 mg/ml). Formulisani fitogel je pokazao i antim...ikrobnu aktivnost. Dobijeni rezultati pokazuju da ispitivani fitogel predstavlja izvor prirodnih antioksidanasa i antimikrobnih agenasa, sa mogućom primenom u farmaceutsko-kozmetičkoj industriji kao alternativa sintetičkim proizvodima.

Keywords:
antioxidant activity / antimicrobial activity / phyto-gel / plant extracts / Na-usniate / antioksidantna aktivnost / antimikrobna aktivnost / fitogel / biljni ekstrakti / Na-usninat
Source:
Advanced Technologies, 2015, 4, 2, 11-18
Publisher:
  • Univerzitet u Nišu - Tehnološki fakultet, Leskovac
Projects:
  • Plants and synthetic bioactive products of new generation (RS-34012)

DOI: 10.5937/savteh1502011C

ISSN: 2406-2979

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URI
http://farfar.pharmacy.bg.ac.rs/handle/123456789/2315
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  • Radovi istraživača / Researchers’ publications
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Pharmacy

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