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Antioksidativna i antimikrobna aktivnost fitogela novije generacije

dc.creatorCvetković, Dragan J.
dc.creatorStanojević, Ljiljana P.
dc.creatorKundaković, Tatjana
dc.creatorZlatković, Saša Ž.
dc.creatorNikolić, Goran
dc.date.accessioned2019-09-02T11:44:36Z
dc.date.available2019-09-02T11:44:36Z
dc.date.issued2015
dc.identifier.issn2406-2979
dc.identifier.urihttp://farfar.pharmacy.bg.ac.rs/handle/123456789/2315
dc.description.abstractAntioxidant and antimicrobial activities of a new phyto-gel were studied in this work. The formulated gel is composed of propilene glycol extracts of St. John's worth (H. perforatum L.), comfrey (S. officinale L.), yarrow (A. millefolium L.), horsetail (E. arvense L.) and Na-usniate. The antioxidant activity was determined for the gel and each investigated extract of the gel separately by the DPPH test. The total phenols and flavonoids content was determined spectrophotometrically, for the gel and each investigated extracts. The antimicrobial activity of the gel and each compound separately was tested in vitro on the following microorganisms: Staphylococcus aureus, Micrococcus luteus, Bacillus subtilis, Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa, Candida albicans and Aspergillus niger. The antioxidant activity of the investigated samples decreases in the series: H. perforatum (EC50 = 1.04 mg/mL) > Na-usniate (EC50 = 4.16 mg/mL) > A. millefolium (EC50 = 7.60 mg/mL) > gel (EC50 = 23.47 mg/mL) > S. officinale (EC50 = 30.10 mg/mL) > E. arvense (EC50 = 44.70 mg/mL). The formulated phyto-gel showed the antimicrobial activity. The results suggest that the obtained phyto-gel is a good source of natural antioxidants and antimicrobial agents, and it has potential as an alternative to synthetic products in pharmaceutical and cosmetic industries.en
dc.description.abstractU radu je ispitivana antioksidativna i antimikrobna aktivnost fitogela - formulacija gela sa propilen-glikolnim ekstraktima H. perforatum, S. officinale, A. millefolium, E. arvense i Na-usninatom. Primenom DPPH testa određena je antioksidativna aktivnost svih ispitivanih ekstrakata, Na-usninata i gela. Primenom spektrofotometrijskih metoda određen je sadržaj ukupnih fenola i flavonoida u ekstraktima i formulisanom gelu. Antimikrobna aktivnost gela, kao i njegovih pojedinačnih komponenata, je ispitivana in vitro na sledećim mikroorganizmima: Staphylococcus aureus, Micrococcus luteus, Bacillus subtilis, Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa, Candida albicans i Aspergillus niger. Antioksidativna aktivnost ispitivanih uzoraka opada u nizu: H. perforatum (EC50=1,04 mg/ml) > Na-usnate (EC50=4,16 mg/ml) > A. millefolium (EC50=7,60 mg/ml) > gel (EC50=23,47 mg/ml) > S. officinale (EC50=30,10 mg/ml) > E. arvense (EC50 44,70 mg/ml). Formulisani fitogel je pokazao i antimikrobnu aktivnost. Dobijeni rezultati pokazuju da ispitivani fitogel predstavlja izvor prirodnih antioksidanasa i antimikrobnih agenasa, sa mogućom primenom u farmaceutsko-kozmetičkoj industriji kao alternativa sintetičkim proizvodima.sr
dc.publisherUniverzitet u Nišu - Tehnološki fakultet, Leskovac
dc.relationinfo:eu-repo/grantAgreement/MESTD/Technological Development (TD or TR)/34012/RS//
dc.rightsopenAccess
dc.sourceAdvanced Technologies
dc.subjectantioxidant activityen
dc.subjectantimicrobial activityen
dc.subjectphyto-gelen
dc.subjectplant extractsen
dc.subjectNa-usniateen
dc.subjectantioksidantna aktivnostsr
dc.subjectantimikrobna aktivnostsr
dc.subjectfitogelsr
dc.subjectbiljni ekstraktisr
dc.subjectNa-usninatsr
dc.titleAntioxidant and antimicrobial activity of a new generation phyto-gelen
dc.titleAntioksidativna i antimikrobna aktivnost fitogela novije generacijesr
dc.typearticle
dc.rights.licenseARR
dcterms.abstractСтанојевић, Љиљана П.; Кундаковић, Татјана; Цветковић, Драган Ј.; Златковић, Саша Ж.; Николић, Горан; Aнтиоксидативна и антимикробна активност фитогела новије генерације; Aнтиоксидативна и антимикробна активност фитогела новије генерације;
dc.citation.volume4
dc.citation.issue2
dc.citation.spage11
dc.citation.epage18
dc.citation.other4(2): 11-18
dc.citation.rankM52
dc.identifier.doi10.5937/savteh1502011C
dc.identifier.fulltexthttp://farfar.pharmacy.bg.ac.rs//bitstream/id/1027/2313.pdf
dc.identifier.rcubconv_1060
dc.type.versionpublishedVersion


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