Deciphering nifedipine in vivo delivery from modified release dosage forms: Identification of food effect
Abstract
With the increased reliance on in vitro dissolution testing as an indicator of in vivo drug behavior and the trend towards the in silico modeling of dosage form performance, the need for bioperformance dissolution methodology development has been enhanced. Determination of the in vivo drug delivery profile is essential for the bioperformance dissolution test development and in vitro/in vivo correlation modeling, as well as the understanding of absorption mechanisms. The aim of this study was to compare different methods in terms of their usefulness and applicability in deciphering in vivo delivery of nifedipine administered in modified release dosage forms. A detailed survey of publications on nifedipine pharmacokinetics was done and used to identify the magnitude of food effect. In vitro dissolution testing was performed under various experimental conditions. Obtained results indicate the potential for using the developed in silico model coupled with discriminative in vitro dissolutio...n data for identification of the in vivo drug product behavior.
Source:
Acta Pharmaceutica, 2015, 65, 4, 427-441Publisher:
- Hrvatsko Farmaceutsko Drustov (HFD)-Croation Pharmaceutical Soc, Zagreb
Funding / projects:
DOI: 10.1515/acph-2015-0039
ISSN: 1330-0075
PubMed: 26677899
WoS: 000366680500006
Scopus: 2-s2.0-84951851189
Collections
Institution/Community
PharmacyTY - JOUR AU - Ilić, Marija AU - Kovacević, Ivan AU - Parojčić, Jelena PY - 2015 UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2316 AB - With the increased reliance on in vitro dissolution testing as an indicator of in vivo drug behavior and the trend towards the in silico modeling of dosage form performance, the need for bioperformance dissolution methodology development has been enhanced. Determination of the in vivo drug delivery profile is essential for the bioperformance dissolution test development and in vitro/in vivo correlation modeling, as well as the understanding of absorption mechanisms. The aim of this study was to compare different methods in terms of their usefulness and applicability in deciphering in vivo delivery of nifedipine administered in modified release dosage forms. A detailed survey of publications on nifedipine pharmacokinetics was done and used to identify the magnitude of food effect. In vitro dissolution testing was performed under various experimental conditions. Obtained results indicate the potential for using the developed in silico model coupled with discriminative in vitro dissolution data for identification of the in vivo drug product behavior. PB - Hrvatsko Farmaceutsko Drustov (HFD)-Croation Pharmaceutical Soc, Zagreb T2 - Acta Pharmaceutica T1 - Deciphering nifedipine in vivo delivery from modified release dosage forms: Identification of food effect VL - 65 IS - 4 SP - 427 EP - 441 DO - 10.1515/acph-2015-0039 ER -
@article{ author = "Ilić, Marija and Kovacević, Ivan and Parojčić, Jelena", year = "2015", abstract = "With the increased reliance on in vitro dissolution testing as an indicator of in vivo drug behavior and the trend towards the in silico modeling of dosage form performance, the need for bioperformance dissolution methodology development has been enhanced. Determination of the in vivo drug delivery profile is essential for the bioperformance dissolution test development and in vitro/in vivo correlation modeling, as well as the understanding of absorption mechanisms. The aim of this study was to compare different methods in terms of their usefulness and applicability in deciphering in vivo delivery of nifedipine administered in modified release dosage forms. A detailed survey of publications on nifedipine pharmacokinetics was done and used to identify the magnitude of food effect. In vitro dissolution testing was performed under various experimental conditions. Obtained results indicate the potential for using the developed in silico model coupled with discriminative in vitro dissolution data for identification of the in vivo drug product behavior.", publisher = "Hrvatsko Farmaceutsko Drustov (HFD)-Croation Pharmaceutical Soc, Zagreb", journal = "Acta Pharmaceutica", title = "Deciphering nifedipine in vivo delivery from modified release dosage forms: Identification of food effect", volume = "65", number = "4", pages = "427-441", doi = "10.1515/acph-2015-0039" }
Ilić, M., Kovacević, I.,& Parojčić, J.. (2015). Deciphering nifedipine in vivo delivery from modified release dosage forms: Identification of food effect. in Acta Pharmaceutica Hrvatsko Farmaceutsko Drustov (HFD)-Croation Pharmaceutical Soc, Zagreb., 65(4), 427-441. https://doi.org/10.1515/acph-2015-0039
Ilić M, Kovacević I, Parojčić J. Deciphering nifedipine in vivo delivery from modified release dosage forms: Identification of food effect. in Acta Pharmaceutica. 2015;65(4):427-441. doi:10.1515/acph-2015-0039 .
Ilić, Marija, Kovacević, Ivan, Parojčić, Jelena, "Deciphering nifedipine in vivo delivery from modified release dosage forms: Identification of food effect" in Acta Pharmaceutica, 65, no. 4 (2015):427-441, https://doi.org/10.1515/acph-2015-0039 . .