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Deciphering nifedipine in vivo delivery from modified release dosage forms: Identification of food effect

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2015
2314.pdf (955.7Kb)
Authors
Ilić, Marija
Kovacević, Ivan
Parojčić, Jelena
Article (Published version)
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Abstract
With the increased reliance on in vitro dissolution testing as an indicator of in vivo drug behavior and the trend towards the in silico modeling of dosage form performance, the need for bioperformance dissolution methodology development has been enhanced. Determination of the in vivo drug delivery profile is essential for the bioperformance dissolution test development and in vitro/in vivo correlation modeling, as well as the understanding of absorption mechanisms. The aim of this study was to compare different methods in terms of their usefulness and applicability in deciphering in vivo delivery of nifedipine administered in modified release dosage forms. A detailed survey of publications on nifedipine pharmacokinetics was done and used to identify the magnitude of food effect. In vitro dissolution testing was performed under various experimental conditions. Obtained results indicate the potential for using the developed in silico model coupled with discriminative in vitro dissolutio...n data for identification of the in vivo drug product behavior.

Source:
Acta Pharmaceutica, 2015, 65, 4, 427-441
Publisher:
  • Hrvatsko Farmaceutsko Drustov (HFD)-Croation Pharmaceutical Soc, Zagreb
Funding / projects:
  • Advanced technologies for controlled release from solid drug delivery systems (RS-34007)

DOI: 10.1515/acph-2015-0039

ISSN: 1330-0075

PubMed: 26677899

WoS: 000366680500006

Scopus: 2-s2.0-84951851189
[ Google Scholar ]
7
4
URI
https://farfar.pharmacy.bg.ac.rs/handle/123456789/2316
Collections
  • Radovi istraživača / Researchers’ publications
Institution/Community
Pharmacy
TY  - JOUR
AU  - Ilić, Marija
AU  - Kovacević, Ivan
AU  - Parojčić, Jelena
PY  - 2015
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2316
AB  - With the increased reliance on in vitro dissolution testing as an indicator of in vivo drug behavior and the trend towards the in silico modeling of dosage form performance, the need for bioperformance dissolution methodology development has been enhanced. Determination of the in vivo drug delivery profile is essential for the bioperformance dissolution test development and in vitro/in vivo correlation modeling, as well as the understanding of absorption mechanisms. The aim of this study was to compare different methods in terms of their usefulness and applicability in deciphering in vivo delivery of nifedipine administered in modified release dosage forms. A detailed survey of publications on nifedipine pharmacokinetics was done and used to identify the magnitude of food effect. In vitro dissolution testing was performed under various experimental conditions. Obtained results indicate the potential for using the developed in silico model coupled with discriminative in vitro dissolution data for identification of the in vivo drug product behavior.
PB  - Hrvatsko Farmaceutsko Drustov (HFD)-Croation Pharmaceutical Soc, Zagreb
T2  - Acta Pharmaceutica
T1  - Deciphering nifedipine in vivo delivery from modified release dosage forms: Identification of food effect
VL  - 65
IS  - 4
SP  - 427
EP  - 441
DO  - 10.1515/acph-2015-0039
ER  - 
@article{
author = "Ilić, Marija and Kovacević, Ivan and Parojčić, Jelena",
year = "2015",
abstract = "With the increased reliance on in vitro dissolution testing as an indicator of in vivo drug behavior and the trend towards the in silico modeling of dosage form performance, the need for bioperformance dissolution methodology development has been enhanced. Determination of the in vivo drug delivery profile is essential for the bioperformance dissolution test development and in vitro/in vivo correlation modeling, as well as the understanding of absorption mechanisms. The aim of this study was to compare different methods in terms of their usefulness and applicability in deciphering in vivo delivery of nifedipine administered in modified release dosage forms. A detailed survey of publications on nifedipine pharmacokinetics was done and used to identify the magnitude of food effect. In vitro dissolution testing was performed under various experimental conditions. Obtained results indicate the potential for using the developed in silico model coupled with discriminative in vitro dissolution data for identification of the in vivo drug product behavior.",
publisher = "Hrvatsko Farmaceutsko Drustov (HFD)-Croation Pharmaceutical Soc, Zagreb",
journal = "Acta Pharmaceutica",
title = "Deciphering nifedipine in vivo delivery from modified release dosage forms: Identification of food effect",
volume = "65",
number = "4",
pages = "427-441",
doi = "10.1515/acph-2015-0039"
}
Ilić, M., Kovacević, I.,& Parojčić, J.. (2015). Deciphering nifedipine in vivo delivery from modified release dosage forms: Identification of food effect. in Acta Pharmaceutica
Hrvatsko Farmaceutsko Drustov (HFD)-Croation Pharmaceutical Soc, Zagreb., 65(4), 427-441.
https://doi.org/10.1515/acph-2015-0039
Ilić M, Kovacević I, Parojčić J. Deciphering nifedipine in vivo delivery from modified release dosage forms: Identification of food effect. in Acta Pharmaceutica. 2015;65(4):427-441.
doi:10.1515/acph-2015-0039 .
Ilić, Marija, Kovacević, Ivan, Parojčić, Jelena, "Deciphering nifedipine in vivo delivery from modified release dosage forms: Identification of food effect" in Acta Pharmaceutica, 65, no. 4 (2015):427-441,
https://doi.org/10.1515/acph-2015-0039 . .

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