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dc.creatorMedarević, Đorđe
dc.creatorKachrimanis, Kyriakos
dc.creatorĐurić, Zorica
dc.creatorIbrić, Svetlana
dc.date.accessioned2019-09-02T11:44:46Z
dc.date.available2019-09-02T11:44:46Z
dc.date.issued2015
dc.identifier.issn0928-0987
dc.identifier.urihttps://farfar.pharmacy.bg.ac.rs/handle/123456789/2321
dc.description.abstractIn this study binary carbamazepine-hydroxypropyl-beta-cyclodextrin, as well as ternary carbamazepine-hydroxypropyl-beta-cyclodextrin-hydrophilic polymer systems were used to improve dissolution rate of carbamazepine. It has been shown that addition of hydrophilic polymers (Soluplus (R) and two types of hydroxypropyl methylcellulose-Metolose (R) 90SH-100 and Metolose (R) 65SH-1500) significantly increased solubilization capacity of hydroxypropyl-B-cyclodextrin for carbamazepine. Evaluation of carbamaze pine-hydroxypropyl-beta-cyclodextrin-hydrophilic polymer interactions using molecular modeling techniques showed interactions between carbamazepine, which dissociates from inclusion complexes and hydroxypropyl methylcellulose that can prevent crystallization of dissolved carbamazepine. These results can contribute to better understanding of drug-cyclodextrin-hydrophilic polymer interactions which are still not well understood. After evaluation of carbamazepine solubilization with hydroxypropyl-beta-cyclodextrin and hydrophilic polymers, both binary carbamazepine-hydroxypropyl-beta-cyclodextrin and ternary carbamazepine-hydroxypropyl-beta-cyclodextrin-hydrophilic polymer systems were prepared by spray drying. The results of solid state characterization methods showed amorphous nature of carbamazepine in all spray dried systems, which together with the results of molecular modeling techniques indicates inclusion complex formation. Carbamazepine dissolution rate was significantly improved from spray dried formulations compared to pure drug. Binary carbamazepine-hydroxypropyl-beta-cyclodextrin and ternary carbamazepine-hydroxypropyl-beta-cyclodextrin-Soluplus (R) systems exhibited the fastest carbamazepine release, wherein the entire amount of carbamazepine was released during first 5 min.en
dc.publisherElsevier Science BV, Amsterdam
dc.relationinfo:eu-repo/grantAgreement/MESTD/Technological Development (TD or TR)/34007/RS//
dc.rightsrestrictedAccess
dc.sourceEuropean Journal of Pharmaceutical Sciences
dc.titleInfluence of hydrophilic polymers on the complexation of carbamazepine with hydroxypropyl-beta-cyclodextrinen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractКацхриманис, Кyриакос; Медаревић, Ђорђе; Ђурић, Зорица; Ибрић, Светлана;
dc.citation.volume78
dc.citation.spage273
dc.citation.epage285
dc.citation.other78: 273-285
dc.citation.rankM21
dc.identifier.wos000361264000029
dc.identifier.doi10.1016/j.ejps.2015.08.001
dc.identifier.pmid26255049
dc.identifier.scopus2-s2.0-84939797808
dc.identifier.rcubconv_3391
dc.type.versionpublishedVersion


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