Приказ основних података о документу

dc.creatorMarković, Bojan
dc.creatorIgnjatović, Janko
dc.creatorVujadinović, Mirjana
dc.creatorSavić, Vedrana
dc.creatorVladimirov, Sote
dc.creatorKarljiković-Rajić, Katarina
dc.date.accessioned2019-09-02T11:44:50Z
dc.date.available2019-09-02T11:44:50Z
dc.date.issued2015
dc.identifier.issn1386-1425
dc.identifier.urihttps://farfar.pharmacy.bg.ac.rs/handle/123456789/2323
dc.description.abstractInter-laboratory verification of European pharmacopoeia (EP) monograph on derivative spectrophotometry (DS) method and its application for chitosan hydrochloride was carried out on two generation of instruments (earlier GBC Cintra 20 and current technology TS Evolution 300). Instruments operate with different versions of Savitzky-Golay algorithm and modes of generating digital derivative spectra. For resolution power parameter, defined as the amplitude ratio A/B in DS method EP monograph, comparable results were obtained only with algorithm's parameters smoothing points (SP) 7 and the 2nd degree polynomial and those provided corresponding data with other two modes on TS Evolution 300 Medium digital indirect and Medium digital direct. Using quoted algorithm's parameters, the differences in percentages between the amplitude ratio A/B averages, were within accepted criteria (+/- 13%) for assay of drug product for method transfer. The deviation of 1.76% for the degree of deacetylation assessment of chitosan hydrochloride, determined on two instruments, (amplitude D-1(202); the 2nd degree polynomial and SP 9 in Savitzky-Golay algorithm), was acceptable, since it was within allowed criteria (+/- 2%) for assay deviation of drug substance, for method transfer in pharmaceutical analyses.en
dc.publisherPergamon-Elsevier Science Ltd, Oxford
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/172041/RS//
dc.rightsrestrictedAccess
dc.sourceSpectroscopy Letters
dc.titleInter-laboratory verification of European pharmacopoeia monograph on derivative spectrophotometry method and its application for chitosan hydrochlorideen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractКарљиковић-Рајић, Катарина; Марковић, Бојан; Владимиров, Соте; Савић, Ведрана; Игњатовић, Јанко; Вујадиновић, Мирјана;
dc.citation.volume150
dc.citation.spage792
dc.citation.epage798
dc.citation.other150: 792-798
dc.citation.rankM22
dc.identifier.wos000361774900093
dc.identifier.doi10.1016/j.saa.2015.06.022
dc.identifier.pmid26112102
dc.identifier.scopus2-s2.0-84934946333
dc.type.versionpublishedVersion


Документи

Thumbnail

Овај документ се појављује у следећим колекцијама

Приказ основних података о документу