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dc.creatorVuković-Dejanović, Vesna
dc.creatorBogavac-Stanojević, Nataša
dc.creatorSpasić, Slavica
dc.creatorSpasojević-Kalimanovska, Vesna
dc.creatorKalimanovska-Oštrić, Dimitra
dc.creatorTopalović, Mirko
dc.creatorJelić-Ivanović, Zorana
dc.date.accessioned2019-09-02T11:44:51Z
dc.date.available2019-09-02T11:44:51Z
dc.date.issued2015
dc.identifier.issn1452-8258
dc.identifier.urihttps://farfar.pharmacy.bg.ac.rs/handle/123456789/2324
dc.description.abstractBackground: We compared factors of inflammation high sensitivity C-reactive protein (hsCRP) and pentraxin-3 (PTX3), and we explored their relationship with coronary artery disease (CAD). Also, we tested the usefulness of hsCRP and PTX3 in the risk assessment of coronary stenosis development and the diagnostic ability of these biomarkers to detect disease severity. Methods: The study group consisted of 93 CAD patients undergoing coronary angiography. Patients were divided into CAD(0), representing subclinical stenosis, and CAD (1-3), representing significant stenosis in one, two or three vessels. Results: We determined the concentration of lipid status parameters, hsCRP and PTX3. We found significantly lower PTX3 and hsCRP concentrations in CAD(0) than in CAD(1-3) group. Concentration of PTX3 showed an increasing trend with the increasing number of vessels affected. The area under ROC curve (AUC) for the combinations of hsCRP and PTX3 with lipid parameters had useful accuracy for detecting CAD(1-3) patients (AUC=0.770, p lt 0.001). Conclusion: PTX3 is a promising independent diagnostic marker for identifying patients with CAD, and a useful indicator of disease progression. In all the analyses PTX3 showed better performance than hsCRP. A combination of PTX3, hsCRP with the lipid status parameters provides risk stratification of the development of coronary stenosis and better classification than their individual application.en
dc.publisherDruštvo medicinskih biohemičara Srbije, Beograd i Versita
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/175035/RS//
dc.rightsopenAccess
dc.sourceJournal of Medical Biochemistry
dc.titleAssociation of Serum Pentraxin-3 and High-Sensitivity C-Reactive Protein with the Extent of Coronary Stenosis in Patients Undergoing Coronary Angiographyen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractБогавац-Станојевић, Наташа; Јелић-Ивановић, Зорана; Вуковић-Дејановић, Весна; Спасић, Славица; Спасојевић-Калимановска, Весна; Калимановска-Оштрић, Димитра; Топаловић, Мирко;
dc.citation.volume34
dc.citation.issue4
dc.citation.spage440
dc.citation.epage449
dc.citation.other34(4): 440-449
dc.citation.rankM23
dc.identifier.wos000363003400007
dc.identifier.doi10.2478/jomb-2014-0061
dc.identifier.pmid28356853
dc.identifier.scopus2-s2.0-84942887972
dc.identifier.fulltexthttps://farfar.pharmacy.bg.ac.rs//bitstream/id/1036/2322.pdf
dc.type.versionpublishedVersion


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