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dc.creatorKrajišnik, Danina
dc.creatorDaković, Aleksandra
dc.creatorMalenović, Anđelija
dc.creatorKragović, Milan
dc.creatorMilić, Jela
dc.date.accessioned2019-09-02T11:44:54Z
dc.date.available2019-09-02T11:44:54Z
dc.date.issued2015
dc.identifier.issn0009-8558
dc.identifier.urihttps://farfar.pharmacy.bg.ac.rs/handle/123456789/2327
dc.description.abstractThe sorption of ibuprofen by modified natural zeolite composites at three concentration levels (10, 20 and 30 mmol/100 g) of cationic surfactants - benzalkonium chloride and cetylpyridinium chloride, in a buffer solution (pH 7.4), was studied. Characterization of the composites before and after ibuprofen sorption was performed by drug sorption and isotherm studies, zeta potential and Fourier Transform infrared spectroscopic analysis. The biopharmaceutical performance of cationic surfactant-modified zeolites as drug formulation excipients was evaluated by in vitro dissolution experiments from the composites with medium surfactant contents. The drug sorption was influenced by the surfactant type and amount used for the zeolite modification. Prolonged drug release over a period of 8 h (up to similar to 40%) was achieved with both groups of samples. The kinetic analysis showed that the drug release profiles were best fitted with the Higuchi and the Bhaskar models, indicating a combination of drug diffusion and ion exchange as the predominant release mechanisms.en
dc.publisherMineralogical Soc, Twickenham
dc.relationinfo:eu-repo/grantAgreement/MESTD/Technological Development (TD or TR)/34031/RS//
dc.rightsrestrictedAccess
dc.sourceClay Minerals
dc.subjectclinoptiloliteen
dc.subjectcationic surfactantsen
dc.subjectsorptionen
dc.subjectexcipienten
dc.subjectibuprofenen
dc.subjectdissolutionen
dc.titleIbuprofen sorption and release by modified natural zeolites as prospective drug carriersen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractКраговић, Милан; Крајишник, Данина; Милић, Јела; Маленовић, Aнђелија; Даковић, Aлександра;
dc.citation.volume50
dc.citation.issue1
dc.citation.spage11
dc.citation.epage22
dc.citation.other50(1): 11-22
dc.citation.rankM23
dc.identifier.wos000362443100003
dc.identifier.doi10.1180/claymin.2015.050.1.02
dc.identifier.scopus2-s2.0-84943771022
dc.identifier.rcubconv_3404
dc.type.versionpublishedVersion


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