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Antimicrobial and Cytotoxic Activity of Extracts of Ferula heuffelii Griseb. ex Heuff. and Its Metabolites

Authorized Users Only
2015
Authors
Pavlović, Ivan
Petrović, Silvana
Milenković, Marina
Stanojković, Tatjana
Nikolić, Dejan
Krunić, Aleksej
Niketić, Marjan
Article (Published version)
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Abstract
The antimicrobial and cytotoxic activities of isolates (CHCl3 and MeOH extracts and selected metabolites) obtained from the underground parts of the Balkan endemic plant Ferula heuffeliiGriseb. ex Heuff. were assessed. The CHCl3 and MeOH extracts exhibited moderate antimicrobial activity, being more pronounced against Gram-positive than Gram-negative bacteria, especially against Staphylococcus aureus (MIC=12.5g/ml for both extracts) and Micrococcus luteus (MIC=50 and 12.5g/ml, resp.). Among the tested metabolites, (6E)-1-(2,4-dihydroxyphenyl)-3,7,11-trimethyl-3-vinyldodeca-6,10-dien-1-one (2) and (2S*,3R*)-2-[(3E)-4,8-dimethylnona-3,7-dien-1-yl]-2,3-dihydro-7-hydroxy-2,3-dimethylfuro[3,2-c]coumarin (4) demonstrated the best antimicrobial activity. Compounds 2 and 4 both strongly inhibited the growth of M. luteus (MIC=11.2 and 5.2M, resp.) and Staphylococcus epidermidis (MIC=22.5 and 10.5M, resp.) and compound 2 additionally also the growth of Bacillus subtilis (MIC=11.2M). The cytotoxi...c activity of the isolates was tested against three human cancer cell lines, viz., cervical adenocarcinoma (HeLa), chronic myelogenous leukemia (K562), and breast cancer (MCF-7) cells. The CHCl3 extract exhibited strong cytotoxic activity against all cell lines (IC50 lt 11.0g/ml). All compounds strongly inhibited the growth of the K562 and HeLa cell lines. Compound 4 exhibited also a strong activity against the MCF-7 cell line, comparable to that of cisplatin (IC50=22.32 +/- 1.32 vs. 18.67 +/- 0.75M).

Source:
Chemistry & Biodiversity, 2015, 12, 10, 1585-1594
Publisher:
  • Wiley-VCH Verlag GMBH, Weinheim
Projects:
  • Investigation on the medicinal plants: morphological, chemical and pharmacological characterisation (RS-173021)

DOI: 10.1002/cbdv.201400400

ISSN: 1612-1872

PubMed: 26460563

WoS: 000362956100010

Scopus: 2-s2.0-84943794133
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URI
http://farfar.pharmacy.bg.ac.rs/handle/123456789/2330
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  • Radovi istraživača / Researchers’ publications
Institution
Pharmacy

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