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dc.creatorĐuričić, Ivana
dc.creatorStanković, Ivan
dc.creatorIvanović, Nevena
dc.creatorTodorović, Vanja
dc.creatorTimić, Jasmina
dc.creatorŠobajić, Slađana
dc.date.accessioned2019-09-02T11:45:16Z
dc.date.available2019-09-02T11:45:16Z
dc.date.issued2015
dc.identifier.issn0250-6807
dc.identifier.urihttps://farfar.pharmacy.bg.ac.rs/handle/123456789/2339
dc.description.abstractIntroduction: It is well known that long-term and regular intakes of long chain (LC) n-3 polyunsaturated fatty acids (PUFAs) from fish or fish oil supplements are useful in improving n-3 fatty status. Dietary guidelines recommend use of these fatty acids in purpose of cardio- vascular primary and secondary preventions. Objectives: The objective of this study was to explore the difference in plasma fatty acid profile following general recommendations for fish intake or fish oil supplement usage. Method / Design: Participants were randomised to receive salmon (oily fish) providing 274 mg EPA + 671 mg DHA/day or commercial fish oil supplement providing 396 mg EPA + 250 mg DHA/ day in cross-over trial over 8 weeks period separated by the 6 months washout period. Fatty acids were extracted from plasma and analysed by gas chromatography. Results: The initial plasma concentration of fatty acids was not different between groups at baseline and after the washout phase. After 8 weeks, there was a significant increase in the level of EPA, DHA and total n-3 fatty acids in plasma of both groups. The percentage values of EPA increased by 135% in salmon group (p<0.0001) and 152% in fish oil group (p<0.0001), whereas DHA increased by 145% in salmon (p<0.0001) and 121% in fish oil group (p<0.010). The increase of plasma total n-3 fatty acids observed after 8 wks of the salmon consumption was greater when compared with fish oil (45% vs 27%) (p<0.05) and mirrored the content in used dietary sources. Conclusions: Plasma n-3 fatty acid profile was remarkably increased with both salmon and fish oil capsules intervention. Increase of plasma EPA and DHA levels was dose-dependent.
dc.publisherKarger, Basel
dc.rightsopenAccess
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/
dc.sourceAnnals of Nutrition and Metabolism
dc.subjectplasmaen
dc.subjectn-3 fatty acidsen
dc.subjectfishen
dc.subjectfish oil supplementsen
dc.titlePlasma fatty acid profile after nutritionally relevant intakes of oily fish and fish oil supplementen
dc.typeconferenceObject
dc.rights.licenseBY-NC-ND
dcterms.abstractТодоровић, Вања; Тимић, Јасмина; Шобајић, Слађана; Ђуричић, Ивана; Ивановић, Невена; Станковић, Иван;
dc.citation.volume67
dc.citation.issueSupplement 1
dc.citation.spage137
dc.citation.epage137
dc.citation.other67: 137-137
dc.citation.rankM22
dc.description.other12th European Nutrition Conference (FENS), Berlin, Germany, October 20-23, 2015
dc.identifier.wos000374988800318
dc.identifier.doi10.1159/000440895
dc.identifier.fulltexthttp://farfar.pharmacy.bg.ac.rs/bitstream/id/11422/Plasma_fatty_acid_pub_2015.pdf
dc.type.versionpublishedVersion


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