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dc.creatorOdović, Jadranka
dc.creatorMarković, Bojan
dc.creatorVladimirov, Sote
dc.creatorKarljiković-Rajić, Katarina
dc.date.accessioned2019-09-02T11:45:38Z
dc.date.available2019-09-02T11:45:38Z
dc.date.issued2015
dc.identifier.issn0021-9665
dc.identifier.urihttp://farfar.pharmacy.bg.ac.rs/handle/123456789/2354
dc.description.abstractTwelve angiotensin-converting enzyme (ACE) inhibitors were studied to evaluate correlation between their absorption (ABS) data available in the literature (22-96%) and hydrophobicity parameters (k(m) and P-m/w) obtained in micellar thin-layer chromatography (MTLC) using Brij 35. The theoretical considerations showed that the geometric molecular descriptor-volume value (Vol) should be considered as an independent variable simultaneously with calculated hydrophobicity parameters in multiple linear regression analysis to obtain reliable correlation between ACE inhibitor's absorption and lipophilicity (calculated KOWWINlog P) and that captopril should be excluded from further correlations. The results of MTLC confirmed that between the two hydrophobicity parameters k(m) and P-m/w, for absorption prediction of 11 ACE inhibitors, the micelle-water partition coefficient P-m/w provided higher correlation (R-2 = 0.756), while for the k(m) parameter R-2 = 0.612 was obtained. The micelle-water partition coefficient Pm/w could be considered as analogous to hydrophobicity parameter C-0 from reversed-phase thin-layer chromatography. Dissimilar retention behavior of lisinopril indicated its lowest non-polar interaction with micelle, because of its di-acid form. The proposed model which included ACE inhibitors on the opposite site of lipophilicity-lisinopril and fosinopril (KOWWINlog P = -0.96 and KOWWINlog P = 6.61, respectively), both with similar absorption values (25 and 36%, respectively), could indicate that absorption of investigated compounds occurs via two different mechanisms: active and passive transport.en
dc.publisherOxford Univ Press Inc, Cary
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/172041/RS//
dc.rightsopenAccess
dc.sourceJournal of Chromatographic Science
dc.titleEvaluation of Angiotensin-Converting Enzyme Inhibitor's Absorption with Retention Data of Micellar Thin-Layer Chromatography and Suitable Molecular Descriptoren
dc.typearticle
dc.rights.licenseARR
dcterms.abstractОдовић, Јадранка; Владимиров, Соте; Карљиковић-Рајић, Катарина; Марковић, Бојан;
dc.citation.volume53
dc.citation.issue10
dc.citation.spage1780
dc.citation.epage1785
dc.citation.other53(10): 1780-1785
dc.citation.rankM23
dc.identifier.wos000368427200022
dc.identifier.doi10.1093/chromsci/bmv091
dc.identifier.pmid26123666
dc.identifier.scopus2-s2.0-84947711105
dc.identifier.fulltexthttp://farfar.pharmacy.bg.ac.rs//bitstream/id/1052/2352.pdf
dc.identifier.rcubconv_3469
dc.type.versionpublishedVersion


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