Sexual dimorphism in the aged rat CD4+T lymphocyte-mediated immune response elicited by inoculation with spinal cord homogenate
Samo za registrovane korisnike
2015
Autori
Nacka-Aleksić, Mirjana
Pilipović, Ivan
Stojić-Vukanić, Zorica

Kosec, Duško
Bufan, Biljana

Vujnović, Ivana
Arsenović-Ranin, Nevena

Dimitrijević, Mirjana

Leposavić, Gordana

Članak u časopisu (Objavljena verzija)

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Considering the crucial pathogenic role of CD4+ T cells in experimental autoimmune encephalomyelitis (EAE) and the opposite direction of the sexual dimorphism in the severity of the disease in 22-24-and 3-month-old dark agouti rats, sex differences in CD4+ T-cell-mediated immune response in aged rats immunized for EAE were examined and compared with those in young animals. In the inductive phase of EAE, fewer activated CD4+ lymphocytes were-retrieved from draining lymph nodes of male (developing less severe disease) compared with female rats, due, at least partly, to their lesser expansion. The former reflected a greater suppressive capacity of CD4+CD25+Foxp3+ cells. Consequently, CD4+ lymphocyte infiltration into the spinal cord of aged male rats was diminished. At the peak of EAE, the frequency of reactivated cells was lower, whereas that of the regulatory CD4+ cells was higher in male rat spinal cord. Consistently, microglial activation and the expression of proinflammatory/damaging... cytokines in male rat spinal cord mononuclear cells were diminished. Additionally, the frequency of the highly pathogenic IL-17+IFN-gamma+ T lymphocytes infiltrating their spinal cord was lower. Together, these results point to (i) an age-specificity in CD4+ cell-mediated immune response and (ii) mechanisms underlying the sex differences in this response in aged rats.
Izvor:
Mechanisms of Ageing and Development, 2015, 152, 15-31Izdavač:
- Elsevier Ireland Ltd, Clare
Projekti:
DOI: 10.1016/j.mad.2015.09.004
ISSN: 0047-6374
PubMed: 26408399