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dc.creatorTrbojević-Stanković, Jasna
dc.creatorOdović, Jadranka
dc.creatorJelić, Ratomir
dc.creatorNešić, Dejan M.
dc.creatorStojimirović, Biljana
dc.date.accessioned2019-09-02T11:45:40Z
dc.date.available2019-09-02T11:45:40Z
dc.date.issued2015
dc.identifier.issn0354-4664
dc.identifier.urihttps://farfar.pharmacy.bg.ac.rs/handle/123456789/2356
dc.description.abstractCalcium channel blockers (CCBs) are among the most widely used drugs in cardiovascular medicine. In this study, nine CCBs (amlodipine, felodipine, isradipine, nicardipine, nifedipine, nimodipine, nisoldipine, verapamil and diltiazem) were investigated to assess the relationship between their molecular properties and elimination data obtained from literature. The descriptors of the molecular properties of CCBs were calculated using three software packages. The relationship between computed molecular properties and elimination data collected from relevant literature, initially investigated with simple linear regression analysis, showed poor correlation (R-2 lt 0.25). Application of molecular weight or volume data as additional independent variable, multiple linear regression (MLR) revealed better correlations (R-2 similar to 0.38) between CCB renal and fecal elimination data and their lipophilicity. Excluding nimodipine from the calculations resulted in more acceptable correlations. The best correlations were established after computed lipophilicity descriptor and molecular weight were applied (R-2 = 0.66 with acceptable probability value).en
dc.publisherSrpsko biološko društvo, Beograd, i dr.
dc.relationinfo:eu-repo/grantAgreement/MESTD/Technological Development (TD or TR)/34031/RS//
dc.rightsopenAccess
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/
dc.sourceArchives of Biological Sciences
dc.subjectCalcium channel blockersen
dc.subjectlipophilicityen
dc.subjectmolecular weighten
dc.subjectelimination routeen
dc.subjectnimodipineen
dc.titleThe effect of the molecular properties of calcium channel blockers on their elimination routeen
dc.typearticle
dc.rights.licenseBY-NC-ND
dcterms.abstractСтојимировић, Биљана; Трбојевић-Станковић, Јасна; Нешић, Дејан М.; Одовић, Јадранка; Јелић, Ратомир;
dc.citation.volume67
dc.citation.issue3
dc.citation.spage801
dc.citation.epage806
dc.citation.other67(3): 801-806
dc.citation.rankM23
dc.identifier.wos000366794800005
dc.identifier.doi10.2298/ABS150127039T
dc.identifier.scopus2-s2.0-84950140507
dc.identifier.fulltexthttps://farfar.pharmacy.bg.ac.rs//bitstream/id/1054/2354.pdf
dc.type.versionpublishedVersion


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Приказ основних података о документу