Infections caused by methicillin-resistant Staphylococcus aureus (MRSA) due to the acquisition of resistance to current antimicrobials pose a serious challenge for therapy, and new measures to treat and prevent this infectious pathogen are of crucial importance. Plant essential oils (EOs) and their constituents are promising agents with antimicrobial properties. The aim of this study was to evaluate the antistaphylococcal effect of essential oils from Salvia officinalis using the broth-microdilution method. Essential oils of S. officinalis were isolated from the same individual, but at different life stages - young and old leaves. The effects of combinations of sub-inhibitory concentrations of oil and different antibiotics were evaluated by the checkerboard method. The results, expressed as the fractional inhibitory concentration (FIC) and index (FICI), indicate that the essential oil isolated from young leaves potentiated the inhibitory effect of antibiotics against tested MRSA strain...s.
Keywords:
Salvia officinalis / essential oil / antibiotics / MRSA
Source:
Archives of Biological Sciences, 2015, 67, 3, 949-956
TY - JOUR
AU - Milenković, Marina
AU - Božić, Dragana
AU - Slavkovska, Violeta
AU - Lakušić, Branislava
PY - 2015
UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2357
AB - Infections caused by methicillin-resistant Staphylococcus aureus (MRSA) due to the acquisition of resistance to current antimicrobials pose a serious challenge for therapy, and new measures to treat and prevent this infectious pathogen are of crucial importance. Plant essential oils (EOs) and their constituents are promising agents with antimicrobial properties. The aim of this study was to evaluate the antistaphylococcal effect of essential oils from Salvia officinalis using the broth-microdilution method. Essential oils of S. officinalis were isolated from the same individual, but at different life stages - young and old leaves. The effects of combinations of sub-inhibitory concentrations of oil and different antibiotics were evaluated by the checkerboard method. The results, expressed as the fractional inhibitory concentration (FIC) and index (FICI), indicate that the essential oil isolated from young leaves potentiated the inhibitory effect of antibiotics against tested MRSA strains.
PB - Srpsko biološko društvo, Beograd, i dr.
T2 - Archives of Biological Sciences
T1 - Synergistic effects of Salvia officinalis L. essential oils and antibiotics against methicillin-resistant Staphylococcus aureus
VL - 67
IS - 3
SP - 949
EP - 956
DO - 10.2298/ABS141119057M
ER -
@article{
author = "Milenković, Marina and Božić, Dragana and Slavkovska, Violeta and Lakušić, Branislava",
year = "2015",
abstract = "Infections caused by methicillin-resistant Staphylococcus aureus (MRSA) due to the acquisition of resistance to current antimicrobials pose a serious challenge for therapy, and new measures to treat and prevent this infectious pathogen are of crucial importance. Plant essential oils (EOs) and their constituents are promising agents with antimicrobial properties. The aim of this study was to evaluate the antistaphylococcal effect of essential oils from Salvia officinalis using the broth-microdilution method. Essential oils of S. officinalis were isolated from the same individual, but at different life stages - young and old leaves. The effects of combinations of sub-inhibitory concentrations of oil and different antibiotics were evaluated by the checkerboard method. The results, expressed as the fractional inhibitory concentration (FIC) and index (FICI), indicate that the essential oil isolated from young leaves potentiated the inhibitory effect of antibiotics against tested MRSA strains.",
publisher = "Srpsko biološko društvo, Beograd, i dr.",
journal = "Archives of Biological Sciences",
title = "Synergistic effects of Salvia officinalis L. essential oils and antibiotics against methicillin-resistant Staphylococcus aureus",
volume = "67",
number = "3",
pages = "949-956",
doi = "10.2298/ABS141119057M"
}
Milenković, M., Božić, D., Slavkovska, V.,& Lakušić, B.. (2015). Synergistic effects of Salvia officinalis L. essential oils and antibiotics against methicillin-resistant Staphylococcus aureus. in Archives of Biological Sciences
Srpsko biološko društvo, Beograd, i dr.., 67(3), 949-956.
https://doi.org/10.2298/ABS141119057M
Milenković M, Božić D, Slavkovska V, Lakušić B. Synergistic effects of Salvia officinalis L. essential oils and antibiotics against methicillin-resistant Staphylococcus aureus. in Archives of Biological Sciences. 2015;67(3):949-956.
doi:10.2298/ABS141119057M .
Milenković, Marina, Božić, Dragana, Slavkovska, Violeta, Lakušić, Branislava, "Synergistic effects of Salvia officinalis L. essential oils and antibiotics against methicillin-resistant Staphylococcus aureus" in Archives of Biological Sciences, 67, no. 3 (2015):949-956,
https://doi.org/10.2298/ABS141119057M . .
