Synergistic effects of Salvia officinalis L. essential oils and antibiotics against methicillin-resistant Staphylococcus aureus
Apstrakt
Infections caused by methicillin-resistant Staphylococcus aureus (MRSA) due to the acquisition of resistance to current antimicrobials pose a serious challenge for therapy, and new measures to treat and prevent this infectious pathogen are of crucial importance. Plant essential oils (EOs) and their constituents are promising agents with antimicrobial properties. The aim of this study was to evaluate the antistaphylococcal effect of essential oils from Salvia officinalis using the broth-microdilution method. Essential oils of S. officinalis were isolated from the same individual, but at different life stages - young and old leaves. The effects of combinations of sub-inhibitory concentrations of oil and different antibiotics were evaluated by the checkerboard method. The results, expressed as the fractional inhibitory concentration (FIC) and index (FICI), indicate that the essential oil isolated from young leaves potentiated the inhibitory effect of antibiotics against tested MRSA strain...s.
Ključne reči:
Salvia officinalis / essential oil / antibiotics / MRSAIzvor:
Archives of Biological Sciences, 2015, 67, 3, 949-956Izdavač:
- Srpsko biološko društvo, Beograd, i dr.
Finansiranje / projekti:
- Ispitivanje lekovitog potencijala biljaka: morfološka, hemijska i farmakološka karakterizacija (RS-173021)
DOI: 10.2298/ABS141119057M
ISSN: 0354-4664
WoS: 000366794800023
Scopus: 2-s2.0-84950114153
Institucija/grupa
PharmacyTY - JOUR AU - Milenković, Marina AU - Božić, Dragana AU - Slavkovska, Violeta AU - Lakušić, Branislava PY - 2015 UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2357 AB - Infections caused by methicillin-resistant Staphylococcus aureus (MRSA) due to the acquisition of resistance to current antimicrobials pose a serious challenge for therapy, and new measures to treat and prevent this infectious pathogen are of crucial importance. Plant essential oils (EOs) and their constituents are promising agents with antimicrobial properties. The aim of this study was to evaluate the antistaphylococcal effect of essential oils from Salvia officinalis using the broth-microdilution method. Essential oils of S. officinalis were isolated from the same individual, but at different life stages - young and old leaves. The effects of combinations of sub-inhibitory concentrations of oil and different antibiotics were evaluated by the checkerboard method. The results, expressed as the fractional inhibitory concentration (FIC) and index (FICI), indicate that the essential oil isolated from young leaves potentiated the inhibitory effect of antibiotics against tested MRSA strains. PB - Srpsko biološko društvo, Beograd, i dr. T2 - Archives of Biological Sciences T1 - Synergistic effects of Salvia officinalis L. essential oils and antibiotics against methicillin-resistant Staphylococcus aureus VL - 67 IS - 3 SP - 949 EP - 956 DO - 10.2298/ABS141119057M ER -
@article{ author = "Milenković, Marina and Božić, Dragana and Slavkovska, Violeta and Lakušić, Branislava", year = "2015", abstract = "Infections caused by methicillin-resistant Staphylococcus aureus (MRSA) due to the acquisition of resistance to current antimicrobials pose a serious challenge for therapy, and new measures to treat and prevent this infectious pathogen are of crucial importance. Plant essential oils (EOs) and their constituents are promising agents with antimicrobial properties. The aim of this study was to evaluate the antistaphylococcal effect of essential oils from Salvia officinalis using the broth-microdilution method. Essential oils of S. officinalis were isolated from the same individual, but at different life stages - young and old leaves. The effects of combinations of sub-inhibitory concentrations of oil and different antibiotics were evaluated by the checkerboard method. The results, expressed as the fractional inhibitory concentration (FIC) and index (FICI), indicate that the essential oil isolated from young leaves potentiated the inhibitory effect of antibiotics against tested MRSA strains.", publisher = "Srpsko biološko društvo, Beograd, i dr.", journal = "Archives of Biological Sciences", title = "Synergistic effects of Salvia officinalis L. essential oils and antibiotics against methicillin-resistant Staphylococcus aureus", volume = "67", number = "3", pages = "949-956", doi = "10.2298/ABS141119057M" }
Milenković, M., Božić, D., Slavkovska, V.,& Lakušić, B.. (2015). Synergistic effects of Salvia officinalis L. essential oils and antibiotics against methicillin-resistant Staphylococcus aureus. in Archives of Biological Sciences Srpsko biološko društvo, Beograd, i dr.., 67(3), 949-956. https://doi.org/10.2298/ABS141119057M
Milenković M, Božić D, Slavkovska V, Lakušić B. Synergistic effects of Salvia officinalis L. essential oils and antibiotics against methicillin-resistant Staphylococcus aureus. in Archives of Biological Sciences. 2015;67(3):949-956. doi:10.2298/ABS141119057M .
Milenković, Marina, Božić, Dragana, Slavkovska, Violeta, Lakušić, Branislava, "Synergistic effects of Salvia officinalis L. essential oils and antibiotics against methicillin-resistant Staphylococcus aureus" in Archives of Biological Sciences, 67, no. 3 (2015):949-956, https://doi.org/10.2298/ABS141119057M . .