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Modified local diatomite as potential functional drug carrier-A model study for diclofenac sodium

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2015
Authors
Janićijević, Jelena
Krajišnik, Danina
Čalija, Bojan
Nedić-Vasiljević, Bojana
Dobričić, Vladimir
Daković, Aleksandra
Antonijević, Milan D.
Milić, Jela
Article (Published version)
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Abstract
Diatomite makes a promising candidate for a drug carrier because of its high porosity, large surface area, modifiable surface chemistry and biocompatibility. Herein, refined diatomite from Kolubara coal basin, which complied with the pharmacopoeial requirements for heavy metals content and microbiological quality, was used as a starting material. Inorganic modification of the starting material was performed through a simple, one-step procedure. Significant increase in adsorbent loading with diclofenac sodium (DS) was achieved after the modification process (similar to 373 mg/g) which enabled the preparation of comprimates containing therapeutic dose of the adsorbed drug. Adsorption of DS onto modified diatomite resulted in the alteration of the drug's XRD pattern and FTIR spectrum. In vitro drug release studies in phosphate buffer pH 7.5 demonstrated prolonged DS release over 8 h from comprimates containing DS adsorbed on modified diatomite (up to 37% after 8 h) and those containing ph...ysical mixture of the same composition (up to 45% after 8 h). The results of in vivo toxicity testing on mice pointed on potential safety of both unmodified (starting) and modified diatomite. All these findings favor the application of diatomite as a potential functional drug carrier.

Source:
International Journal of Pharmaceutics, 2015, 496, 2, 466-474
Publisher:
  • Elsevier Science BV, Amsterdam
Projects:
  • Development of micro- and nanosystems as carriers for drugs with anti-inflammatory effect and methods for their characterization (RS-34031)

DOI: 10.1016/j.ijpharm.2015.10.047

ISSN: 0378-5173

PubMed: 26498370

WoS: 000367384700031

Scopus: 2-s2.0-84949564307
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URI
http://farfar.pharmacy.bg.ac.rs/handle/123456789/2360
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  • Radovi istraživača / Researchers’ publications
Institution
Pharmacy

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