Modified local diatomite as potential functional drug carrier-A model study for diclofenac sodium
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2015
Authors
Janićijević, JelenaKrajišnik, Danina
Čalija, Bojan
Nedić-Vasiljević, Bojana
Dobričić, Vladimir
Daković, Aleksandra
Antonijević, Milan D.
Milić, Jela
Article (Published version)
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Diatomite makes a promising candidate for a drug carrier because of its high porosity, large surface area, modifiable surface chemistry and biocompatibility. Herein, refined diatomite from Kolubara coal basin, which complied with the pharmacopoeial requirements for heavy metals content and microbiological quality, was used as a starting material. Inorganic modification of the starting material was performed through a simple, one-step procedure. Significant increase in adsorbent loading with diclofenac sodium (DS) was achieved after the modification process (similar to 373 mg/g) which enabled the preparation of comprimates containing therapeutic dose of the adsorbed drug. Adsorption of DS onto modified diatomite resulted in the alteration of the drug's XRD pattern and FTIR spectrum. In vitro drug release studies in phosphate buffer pH 7.5 demonstrated prolonged DS release over 8 h from comprimates containing DS adsorbed on modified diatomite (up to 37% after 8 h) and those containing ph...ysical mixture of the same composition (up to 45% after 8 h). The results of in vivo toxicity testing on mice pointed on potential safety of both unmodified (starting) and modified diatomite. All these findings favor the application of diatomite as a potential functional drug carrier.
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International Journal of Pharmaceutics, 2015, 496, 2, 466-474Publisher:
- Elsevier Science BV, Amsterdam
Funding / projects:
DOI: 10.1016/j.ijpharm.2015.10.047
ISSN: 0378-5173
PubMed: 26498370
WoS: 000367384700031
Scopus: 2-s2.0-84949564307
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PharmacyTY - JOUR AU - Janićijević, Jelena AU - Krajišnik, Danina AU - Čalija, Bojan AU - Nedić-Vasiljević, Bojana AU - Dobričić, Vladimir AU - Daković, Aleksandra AU - Antonijević, Milan D. AU - Milić, Jela PY - 2015 UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2360 AB - Diatomite makes a promising candidate for a drug carrier because of its high porosity, large surface area, modifiable surface chemistry and biocompatibility. Herein, refined diatomite from Kolubara coal basin, which complied with the pharmacopoeial requirements for heavy metals content and microbiological quality, was used as a starting material. Inorganic modification of the starting material was performed through a simple, one-step procedure. Significant increase in adsorbent loading with diclofenac sodium (DS) was achieved after the modification process (similar to 373 mg/g) which enabled the preparation of comprimates containing therapeutic dose of the adsorbed drug. Adsorption of DS onto modified diatomite resulted in the alteration of the drug's XRD pattern and FTIR spectrum. In vitro drug release studies in phosphate buffer pH 7.5 demonstrated prolonged DS release over 8 h from comprimates containing DS adsorbed on modified diatomite (up to 37% after 8 h) and those containing physical mixture of the same composition (up to 45% after 8 h). The results of in vivo toxicity testing on mice pointed on potential safety of both unmodified (starting) and modified diatomite. All these findings favor the application of diatomite as a potential functional drug carrier. PB - Elsevier Science BV, Amsterdam T2 - International Journal of Pharmaceutics T1 - Modified local diatomite as potential functional drug carrier-A model study for diclofenac sodium VL - 496 IS - 2 SP - 466 EP - 474 DO - 10.1016/j.ijpharm.2015.10.047 ER -
@article{ author = "Janićijević, Jelena and Krajišnik, Danina and Čalija, Bojan and Nedić-Vasiljević, Bojana and Dobričić, Vladimir and Daković, Aleksandra and Antonijević, Milan D. and Milić, Jela", year = "2015", abstract = "Diatomite makes a promising candidate for a drug carrier because of its high porosity, large surface area, modifiable surface chemistry and biocompatibility. Herein, refined diatomite from Kolubara coal basin, which complied with the pharmacopoeial requirements for heavy metals content and microbiological quality, was used as a starting material. Inorganic modification of the starting material was performed through a simple, one-step procedure. Significant increase in adsorbent loading with diclofenac sodium (DS) was achieved after the modification process (similar to 373 mg/g) which enabled the preparation of comprimates containing therapeutic dose of the adsorbed drug. Adsorption of DS onto modified diatomite resulted in the alteration of the drug's XRD pattern and FTIR spectrum. In vitro drug release studies in phosphate buffer pH 7.5 demonstrated prolonged DS release over 8 h from comprimates containing DS adsorbed on modified diatomite (up to 37% after 8 h) and those containing physical mixture of the same composition (up to 45% after 8 h). The results of in vivo toxicity testing on mice pointed on potential safety of both unmodified (starting) and modified diatomite. All these findings favor the application of diatomite as a potential functional drug carrier.", publisher = "Elsevier Science BV, Amsterdam", journal = "International Journal of Pharmaceutics", title = "Modified local diatomite as potential functional drug carrier-A model study for diclofenac sodium", volume = "496", number = "2", pages = "466-474", doi = "10.1016/j.ijpharm.2015.10.047" }
Janićijević, J., Krajišnik, D., Čalija, B., Nedić-Vasiljević, B., Dobričić, V., Daković, A., Antonijević, M. D.,& Milić, J.. (2015). Modified local diatomite as potential functional drug carrier-A model study for diclofenac sodium. in International Journal of Pharmaceutics Elsevier Science BV, Amsterdam., 496(2), 466-474. https://doi.org/10.1016/j.ijpharm.2015.10.047
Janićijević J, Krajišnik D, Čalija B, Nedić-Vasiljević B, Dobričić V, Daković A, Antonijević MD, Milić J. Modified local diatomite as potential functional drug carrier-A model study for diclofenac sodium. in International Journal of Pharmaceutics. 2015;496(2):466-474. doi:10.1016/j.ijpharm.2015.10.047 .
Janićijević, Jelena, Krajišnik, Danina, Čalija, Bojan, Nedić-Vasiljević, Bojana, Dobričić, Vladimir, Daković, Aleksandra, Antonijević, Milan D., Milić, Jela, "Modified local diatomite as potential functional drug carrier-A model study for diclofenac sodium" in International Journal of Pharmaceutics, 496, no. 2 (2015):466-474, https://doi.org/10.1016/j.ijpharm.2015.10.047 . .