Oxidative stress, bioelements and androgen status in testes of rats subacutely exposed to cadmium
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2015
Authors
Đurić, Ana
Begić, Aida
Gobeljić, Borko

Stanojević, Ivan
Ninković, Milica
Vojvodić, Danilo

Pantelić, Ana
Zebić, Goran
Prokić, Vera
Dejanović, Bratislav
Stojanović, Ivana
Pavlica, Marina
Đukić, Dušan
Saso, Luciano

Đurđević, Dragan
Pavlović, Miloš
Topić, Aleksandra

Vujanović, Dragana

Stevnović, Ivana
Đukić, Mirjana

Article (Published version)

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Show full item recordAbstract
The objective of our study was to examine testicular toxicity of cadmium (Cd), focusing on oxidative stress (OS), essential metals and androgenic status and morphological changes. Male Wistar rats [controls and four Cd-subgroups (n = 6) organized according to the exposure (1, 3, 10 and 21 days)] were intraperitoneally (i.p.) treated with 1 mg CdCl2/kg/day. Testicular Cd deposition was noticed from the 1st day. After 10 and 21 days, copper (Cu) and iron (Fe) increased by 60-109% and 43-67%, respectively, while zinc (Zn) decreased by 24-33%. During 121 days of the exposure, decrease in testicular total superoxide dismutase (SOD) and total glutathione-s-transferase (GST) activities occurred gradually by 30-78% and 15-84%, respectively, while superoxide anion radical (O-2(center dot-)) increased gradually by 114-271%. After 10-21 days, decrease in testicular catalase (CAT) activity appeared by 13-31%. After 21 days, malondialdehyde (MDA) decreased by 44% and the ratio of oxidized glutathio...ne/reduced glutathione (GSSG/GSH) increased by 130% in testes of the rats exposed to Cd. Additionally, decreased testicular testosterone level and the relative testes mass, along with induced microscopic and macroscopic changes were occured, what can be explained as the consequence of instantly developed OS, impaired essential metals status and Cd testicular deposition.
Source:
Food and Chemical Toxicology, 2015, 86, 25-33Publisher:
- Pergamon-Elsevier Science Ltd, Oxford
Projects:
DOI: 10.1016/j.fct.2015.09.004
ISSN: 0278-6915
PubMed: 26385724