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Oxidative stress, bioelements and androgen status in testes of rats subacutely exposed to cadmium

Authorized Users Only
2015
Authors
Đurić, Ana
Begić, Aida
Gobeljić, Borko
Stanojević, Ivan
Ninković, Milica
Vojvodić, Danilo
Pantelić, Ana
Zebić, Goran
Prokić, Vera
Dejanović, Bratislav
Stojanović, Ivana
Pavlica, Marina
Đukić, Dušan
Saso, Luciano
Đurđević, Dragan
Pavlović, Miloš
Topić, Aleksandra
Vujanović, Dragana
Stevnović, Ivana
Đukić, Mirjana
Article (Published version)
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Abstract
The objective of our study was to examine testicular toxicity of cadmium (Cd), focusing on oxidative stress (OS), essential metals and androgenic status and morphological changes. Male Wistar rats [controls and four Cd-subgroups (n = 6) organized according to the exposure (1, 3, 10 and 21 days)] were intraperitoneally (i.p.) treated with 1 mg CdCl2/kg/day. Testicular Cd deposition was noticed from the 1st day. After 10 and 21 days, copper (Cu) and iron (Fe) increased by 60-109% and 43-67%, respectively, while zinc (Zn) decreased by 24-33%. During 121 days of the exposure, decrease in testicular total superoxide dismutase (SOD) and total glutathione-s-transferase (GST) activities occurred gradually by 30-78% and 15-84%, respectively, while superoxide anion radical (O-2(center dot-)) increased gradually by 114-271%. After 10-21 days, decrease in testicular catalase (CAT) activity appeared by 13-31%. After 21 days, malondialdehyde (MDA) decreased by 44% and the ratio of oxidized glutathio...ne/reduced glutathione (GSSG/GSH) increased by 130% in testes of the rats exposed to Cd. Additionally, decreased testicular testosterone level and the relative testes mass, along with induced microscopic and macroscopic changes were occured, what can be explained as the consequence of instantly developed OS, impaired essential metals status and Cd testicular deposition.

Source:
Food and Chemical Toxicology, 2015, 86, 25-33
Publisher:
  • Pergamon-Elsevier Science Ltd, Oxford
Projects:
  • Preventive, therapeutic, and ethical approach in preclinical and clinical studies of the genes and modulators of redox cell signaling in immune, inflammatory and proliferative cell response (RS-41018)

DOI: 10.1016/j.fct.2015.09.004

ISSN: 0278-6915

PubMed: 26385724

WoS: 000368203200004

Scopus: 2-s2.0-84942583403
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URI
http://farfar.pharmacy.bg.ac.rs/handle/123456789/2364
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  • Radovi istraživača / Researchers’ publications
Institution
Pharmacy

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