The chromatographic behavior of cephalexine, cefaclore, ceftriaxone, cefiuime, and cefotaxime has been investigated on silica gel layers with binary mobile phases containing different amounts of organic modifier. The influence of type, chemical character, and position of substitution of functional groups (steric and structural effects) on the retention of analyzed compounds was of particular interest. Systematic investigation of the cephalosporins furnished much information about their hydrophobicity (R-M(0)), the mechanism of adsorption, and the possibilities of separation. Correlation of the hydrophobicity parameters R-M(0), m, and C-0 with the lipophilicity parameter log P was established by use of linear equations. The parameter C-0 was considered as directly applicable in quantitative structure-activity relationships of the cephalosporins.
Keywords:
Cephalosporins / Hydrophobicity (R(M) 0 , m, and C 0 ) / Lipophilicity (log P) / Mechanism of adsorption / Quantitative structure-activity relationships (QSAR)
Source:
Journal of Planar Chromatography - Modern TLC, 2000, 13, 2, 88-92
TY - JOUR
AU - Erić, Slavica
AU - Agbaba, Danica
AU - Vladimirov, S
AU - Živanov-Stakić, Dobrila
PY - 2000
UR - http://farfar.pharmacy.bg.ac.rs/handle/123456789/237
AB - The chromatographic behavior of cephalexine, cefaclore, ceftriaxone, cefiuime, and cefotaxime has been investigated on silica gel layers with binary mobile phases containing different amounts of organic modifier. The influence of type, chemical character, and position of substitution of functional groups (steric and structural effects) on the retention of analyzed compounds was of particular interest. Systematic investigation of the cephalosporins furnished much information about their hydrophobicity (R-M(0)), the mechanism of adsorption, and the possibilities of separation. Correlation of the hydrophobicity parameters R-M(0), m, and C-0 with the lipophilicity parameter log P was established by use of linear equations. The parameter C-0 was considered as directly applicable in quantitative structure-activity relationships of the cephalosporins.
PB - Springer Hungarica Kiado Kft, Budapest
T2 - Journal of Planar Chromatography - Modern TLC
T1 - The retention behavior of several semisynthetic cephalosporins in planar chromatography
VL - 13
IS - 2
SP - 88
EP - 92
ER -
@article{
author = "Erić, Slavica and Agbaba, Danica and Vladimirov, S and Živanov-Stakić, Dobrila",
year = "2000",
url = "http://farfar.pharmacy.bg.ac.rs/handle/123456789/237",
abstract = "The chromatographic behavior of cephalexine, cefaclore, ceftriaxone, cefiuime, and cefotaxime has been investigated on silica gel layers with binary mobile phases containing different amounts of organic modifier. The influence of type, chemical character, and position of substitution of functional groups (steric and structural effects) on the retention of analyzed compounds was of particular interest. Systematic investigation of the cephalosporins furnished much information about their hydrophobicity (R-M(0)), the mechanism of adsorption, and the possibilities of separation. Correlation of the hydrophobicity parameters R-M(0), m, and C-0 with the lipophilicity parameter log P was established by use of linear equations. The parameter C-0 was considered as directly applicable in quantitative structure-activity relationships of the cephalosporins.",
publisher = "Springer Hungarica Kiado Kft, Budapest",
journal = "Journal of Planar Chromatography - Modern TLC",
title = "The retention behavior of several semisynthetic cephalosporins in planar chromatography",
volume = "13",
number = "2",
pages = "88-92"
}
Erić, S., Agbaba, D., Vladimirov, S.,& Živanov-Stakić, D. (2000). The retention behavior of several semisynthetic cephalosporins in planar chromatography.
Journal of Planar Chromatography - Modern TLC
Springer Hungarica Kiado Kft, Budapest., 13(2), 88-92.
Erić S, Agbaba D, Vladimirov S, Živanov-Stakić D. The retention behavior of several semisynthetic cephalosporins in planar chromatography. Journal of Planar Chromatography - Modern TLC. 2000;13(2):88-92
Erić Slavica, Agbaba Danica, Vladimirov S, Živanov-Stakić Dobrila, "The retention behavior of several semisynthetic cephalosporins in planar chromatography" Journal of Planar Chromatography - Modern TLC, 13, no. 2 (2000):88-92
