Pathogenicity of methicillin-resistant Staphylococcus aureus (MRSA) is associated with a broad spectrum of virulence factors, amongst which is a-hemolysin. The aim of this study was to investigate the effect of three newly-synthesized chalcones (1,3- Bis-(2-hydroxy-phenyl)propenone, 3(3-Hydroxy-phenyl)-1-(2-hydroxy-phenyl)-propenone and 3-(4-Hydroxy-phenyl)-1-(2-hydroxy-phenyl)-propenone) on a-hemolysin production of clinical isolates of MRSA. Subinhibitory concentrations of the tested compounds reduced hemolytic activity of MRSA strains, with almost complete abolishment of hemolysis at concentrations in the range of 1/2-1/4 x MIC (25-12.5 mu g/ml). In conclusion, newly-synthesized chalcones tested in this study showed potent inhibitory activity on a-hemolysin production of multiresistant and genetically diverse MRSA strains.
Keywords:
alpha-hemolysin / chalcones / MRSA
Source:
Polish Journal of Microbiology, 2015, 64, 4, 379-382
Publisher:
Polskie Towarzystwo Mikrobiologow-Polish Society Of Microbiologists, Warsaw
TY - JOUR
AU - Božić, Dragana
AU - Milenković, Marina
AU - Ivković, Branka
AU - Larsen, Anders Rhod
AU - Cirković, Ivana
PY - 2015
UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2374
AB - Pathogenicity of methicillin-resistant Staphylococcus aureus (MRSA) is associated with a broad spectrum of virulence factors, amongst which is a-hemolysin. The aim of this study was to investigate the effect of three newly-synthesized chalcones (1,3- Bis-(2-hydroxy-phenyl)propenone, 3(3-Hydroxy-phenyl)-1-(2-hydroxy-phenyl)-propenone and 3-(4-Hydroxy-phenyl)-1-(2-hydroxy-phenyl)-propenone) on a-hemolysin production of clinical isolates of MRSA. Subinhibitory concentrations of the tested compounds reduced hemolytic activity of MRSA strains, with almost complete abolishment of hemolysis at concentrations in the range of 1/2-1/4 x MIC (25-12.5 mu g/ml). In conclusion, newly-synthesized chalcones tested in this study showed potent inhibitory activity on a-hemolysin production of multiresistant and genetically diverse MRSA strains.
PB - Polskie Towarzystwo Mikrobiologow-Polish Society Of Microbiologists, Warsaw
T2 - Polish Journal of Microbiology
T1 - Inhibitory Effect of Newly-Synthesized Chalcones on Hemolytic Activity of Methicillin-Resistant Staphylococcus aureus
VL - 64
IS - 4
SP - 379
EP - 382
DO - 10.5604/17331331.1185237
ER -
@article{
author = "Božić, Dragana and Milenković, Marina and Ivković, Branka and Larsen, Anders Rhod and Cirković, Ivana",
year = "2015",
abstract = "Pathogenicity of methicillin-resistant Staphylococcus aureus (MRSA) is associated with a broad spectrum of virulence factors, amongst which is a-hemolysin. The aim of this study was to investigate the effect of three newly-synthesized chalcones (1,3- Bis-(2-hydroxy-phenyl)propenone, 3(3-Hydroxy-phenyl)-1-(2-hydroxy-phenyl)-propenone and 3-(4-Hydroxy-phenyl)-1-(2-hydroxy-phenyl)-propenone) on a-hemolysin production of clinical isolates of MRSA. Subinhibitory concentrations of the tested compounds reduced hemolytic activity of MRSA strains, with almost complete abolishment of hemolysis at concentrations in the range of 1/2-1/4 x MIC (25-12.5 mu g/ml). In conclusion, newly-synthesized chalcones tested in this study showed potent inhibitory activity on a-hemolysin production of multiresistant and genetically diverse MRSA strains.",
publisher = "Polskie Towarzystwo Mikrobiologow-Polish Society Of Microbiologists, Warsaw",
journal = "Polish Journal of Microbiology",
title = "Inhibitory Effect of Newly-Synthesized Chalcones on Hemolytic Activity of Methicillin-Resistant Staphylococcus aureus",
volume = "64",
number = "4",
pages = "379-382",
doi = "10.5604/17331331.1185237"
}
Božić, D., Milenković, M., Ivković, B., Larsen, A. R.,& Cirković, I.. (2015). Inhibitory Effect of Newly-Synthesized Chalcones on Hemolytic Activity of Methicillin-Resistant Staphylococcus aureus. in Polish Journal of Microbiology
Polskie Towarzystwo Mikrobiologow-Polish Society Of Microbiologists, Warsaw., 64(4), 379-382.
https://doi.org/10.5604/17331331.1185237
Božić D, Milenković M, Ivković B, Larsen AR, Cirković I. Inhibitory Effect of Newly-Synthesized Chalcones on Hemolytic Activity of Methicillin-Resistant Staphylococcus aureus. in Polish Journal of Microbiology. 2015;64(4):379-382.
doi:10.5604/17331331.1185237 .
Božić, Dragana, Milenković, Marina, Ivković, Branka, Larsen, Anders Rhod, Cirković, Ivana, "Inhibitory Effect of Newly-Synthesized Chalcones on Hemolytic Activity of Methicillin-Resistant Staphylococcus aureus" in Polish Journal of Microbiology, 64, no. 4 (2015):379-382,
https://doi.org/10.5604/17331331.1185237 . .
