FarFaR - Pharmacy Repository
University of Belgrade, Faculty of Pharmacy
    • English
    • Српски
    • Српски (Serbia)
  • English 
    • English
    • Serbian (Cyrilic)
    • Serbian (Latin)
  • Login
View Item 
  •   FarFaR
  • Pharmacy
  • Radovi istraživača / Researchers’ publications
  • View Item
  •   FarFaR
  • Pharmacy
  • Radovi istraživača / Researchers’ publications
  • View Item
JavaScript is disabled for your browser. Some features of this site may not work without it.

Inhibitory Effect of Newly-Synthesized Chalcones on Hemolytic Activity of Methicillin-Resistant Staphylococcus aureus

Thumbnail
2015
2372.pdf (790.2Kb)
Authors
Božić, Dragana
Milenković, Marina
Ivković, Branka
Larsen, Anders Rhod
Cirković, Ivana
Article (Published version)
Metadata
Show full item record
Abstract
Pathogenicity of methicillin-resistant Staphylococcus aureus (MRSA) is associated with a broad spectrum of virulence factors, amongst which is a-hemolysin. The aim of this study was to investigate the effect of three newly-synthesized chalcones (1,3- Bis-(2-hydroxy-phenyl)propenone, 3(3-Hydroxy-phenyl)-1-(2-hydroxy-phenyl)-propenone and 3-(4-Hydroxy-phenyl)-1-(2-hydroxy-phenyl)-propenone) on a-hemolysin production of clinical isolates of MRSA. Subinhibitory concentrations of the tested compounds reduced hemolytic activity of MRSA strains, with almost complete abolishment of hemolysis at concentrations in the range of 1/2-1/4 x MIC (25-12.5 mu g/ml). In conclusion, newly-synthesized chalcones tested in this study showed potent inhibitory activity on a-hemolysin production of multiresistant and genetically diverse MRSA strains.
Keywords:
alpha-hemolysin / chalcones / MRSA
Source:
Polish Journal of Microbiology, 2015, 64, 4, 379-382
Publisher:
  • Polskie Towarzystwo Mikrobiologow-Polish Society Of Microbiologists, Warsaw
Projects:
  • Antibiotic resistant bacterial pathogens in Serbia: phenotypic and genotypic characterization (RS-175039)

DOI: 10.5604/17331331.1185237

ISSN: 1733-1331

PubMed: 26999958

WoS: 000367494600008

Scopus: 2-s2.0-84959256955
[ Google Scholar ]
1
1
URI
http://farfar.pharmacy.bg.ac.rs/handle/123456789/2374
Collections
  • Radovi istraživača / Researchers’ publications
Institution
Pharmacy
TY  - JOUR
AU  - Božić, Dragana
AU  - Milenković, Marina
AU  - Ivković, Branka
AU  - Larsen, Anders Rhod
AU  - Cirković, Ivana
PY  - 2015
UR  - http://farfar.pharmacy.bg.ac.rs/handle/123456789/2374
AB  - Pathogenicity of methicillin-resistant Staphylococcus aureus (MRSA) is associated with a broad spectrum of virulence factors, amongst which is a-hemolysin. The aim of this study was to investigate the effect of three newly-synthesized chalcones (1,3- Bis-(2-hydroxy-phenyl)propenone, 3(3-Hydroxy-phenyl)-1-(2-hydroxy-phenyl)-propenone and 3-(4-Hydroxy-phenyl)-1-(2-hydroxy-phenyl)-propenone) on a-hemolysin production of clinical isolates of MRSA. Subinhibitory concentrations of the tested compounds reduced hemolytic activity of MRSA strains, with almost complete abolishment of hemolysis at concentrations in the range of 1/2-1/4 x MIC (25-12.5 mu g/ml). In conclusion, newly-synthesized chalcones tested in this study showed potent inhibitory activity on a-hemolysin production of multiresistant and genetically diverse MRSA strains.
PB  - Polskie Towarzystwo Mikrobiologow-Polish Society Of Microbiologists, Warsaw
T2  - Polish Journal of Microbiology
T1  - Inhibitory Effect of Newly-Synthesized Chalcones on Hemolytic Activity of Methicillin-Resistant Staphylococcus aureus
VL  - 64
IS  - 4
SP  - 379
EP  - 382
DO  - 10.5604/17331331.1185237
ER  - 
@article{
author = "Božić, Dragana and Milenković, Marina and Ivković, Branka and Larsen, Anders Rhod and Cirković, Ivana",
year = "2015",
url = "http://farfar.pharmacy.bg.ac.rs/handle/123456789/2374",
abstract = "Pathogenicity of methicillin-resistant Staphylococcus aureus (MRSA) is associated with a broad spectrum of virulence factors, amongst which is a-hemolysin. The aim of this study was to investigate the effect of three newly-synthesized chalcones (1,3- Bis-(2-hydroxy-phenyl)propenone, 3(3-Hydroxy-phenyl)-1-(2-hydroxy-phenyl)-propenone and 3-(4-Hydroxy-phenyl)-1-(2-hydroxy-phenyl)-propenone) on a-hemolysin production of clinical isolates of MRSA. Subinhibitory concentrations of the tested compounds reduced hemolytic activity of MRSA strains, with almost complete abolishment of hemolysis at concentrations in the range of 1/2-1/4 x MIC (25-12.5 mu g/ml). In conclusion, newly-synthesized chalcones tested in this study showed potent inhibitory activity on a-hemolysin production of multiresistant and genetically diverse MRSA strains.",
publisher = "Polskie Towarzystwo Mikrobiologow-Polish Society Of Microbiologists, Warsaw",
journal = "Polish Journal of Microbiology",
title = "Inhibitory Effect of Newly-Synthesized Chalcones on Hemolytic Activity of Methicillin-Resistant Staphylococcus aureus",
volume = "64",
number = "4",
pages = "379-382",
doi = "10.5604/17331331.1185237"
}
Božić D, Milenković M, Ivković B, Larsen AR, Cirković I. Inhibitory Effect of Newly-Synthesized Chalcones on Hemolytic Activity of Methicillin-Resistant Staphylococcus aureus. Polish Journal of Microbiology. 2015;64(4):379-382
Božić, D., Milenković, M., Ivković, B., Larsen, A. R.,& Cirković, I. (2015). Inhibitory Effect of Newly-Synthesized Chalcones on Hemolytic Activity of Methicillin-Resistant Staphylococcus aureus.
Polish Journal of MicrobiologyPolskie Towarzystwo Mikrobiologow-Polish Society Of Microbiologists, Warsaw., 64(4), 379-382.
https://doi.org/10.5604/17331331.1185237
Božić Dragana, Milenković Marina, Ivković Branka, Larsen Anders Rhod, Cirković Ivana, "Inhibitory Effect of Newly-Synthesized Chalcones on Hemolytic Activity of Methicillin-Resistant Staphylococcus aureus" 64, no. 4 (2015):379-382,
https://doi.org/10.5604/17331331.1185237 .

DSpace software copyright © 2002-2015  DuraSpace
About FarFaR - Pharmacy Repository | Send Feedback

OpenAIRERCUB
 

 

All of DSpaceInstitutionsAuthorsTitlesSubjectsThis institutionAuthorsTitlesSubjects

Statistics

View Usage Statistics

DSpace software copyright © 2002-2015  DuraSpace
About FarFaR - Pharmacy Repository | Send Feedback

OpenAIRERCUB