Inhibitory Effect of Newly-Synthesized Chalcones on Hemolytic Activity of Methicillin-Resistant Staphylococcus aureus
Abstract
Pathogenicity of methicillin-resistant Staphylococcus aureus (MRSA) is associated with a broad spectrum of virulence factors, amongst which is a-hemolysin. The aim of this study was to investigate the effect of three newly-synthesized chalcones (1,3- Bis-(2-hydroxy-phenyl)propenone, 3(3-Hydroxy-phenyl)-1-(2-hydroxy-phenyl)-propenone and 3-(4-Hydroxy-phenyl)-1-(2-hydroxy-phenyl)-propenone) on a-hemolysin production of clinical isolates of MRSA. Subinhibitory concentrations of the tested compounds reduced hemolytic activity of MRSA strains, with almost complete abolishment of hemolysis at concentrations in the range of 1/2-1/4 x MIC (25-12.5 mu g/ml). In conclusion, newly-synthesized chalcones tested in this study showed potent inhibitory activity on a-hemolysin production of multiresistant and genetically diverse MRSA strains.
Keywords:
alpha-hemolysin / chalcones / MRSASource:
Polish Journal of Microbiology, 2015, 64, 4, 379-382Publisher:
- Polskie Towarzystwo Mikrobiologow-Polish Society Of Microbiologists, Warsaw
Funding / projects:
- Antibiotic resistant bacterial pathogens in Serbia: phenotypic and genotypic characterization (RS-MESTD-Basic Research (BR or ON)-175039)
DOI: 10.5604/17331331.1185237
ISSN: 1733-1331
PubMed: 26999958
WoS: 000367494600008
Scopus: 2-s2.0-84959256955
Collections
Institution/Community
PharmacyTY - JOUR AU - Božić, Dragana AU - Milenković, Marina AU - Ivković, Branka AU - Larsen, Anders Rhod AU - Cirković, Ivana PY - 2015 UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2374 AB - Pathogenicity of methicillin-resistant Staphylococcus aureus (MRSA) is associated with a broad spectrum of virulence factors, amongst which is a-hemolysin. The aim of this study was to investigate the effect of three newly-synthesized chalcones (1,3- Bis-(2-hydroxy-phenyl)propenone, 3(3-Hydroxy-phenyl)-1-(2-hydroxy-phenyl)-propenone and 3-(4-Hydroxy-phenyl)-1-(2-hydroxy-phenyl)-propenone) on a-hemolysin production of clinical isolates of MRSA. Subinhibitory concentrations of the tested compounds reduced hemolytic activity of MRSA strains, with almost complete abolishment of hemolysis at concentrations in the range of 1/2-1/4 x MIC (25-12.5 mu g/ml). In conclusion, newly-synthesized chalcones tested in this study showed potent inhibitory activity on a-hemolysin production of multiresistant and genetically diverse MRSA strains. PB - Polskie Towarzystwo Mikrobiologow-Polish Society Of Microbiologists, Warsaw T2 - Polish Journal of Microbiology T1 - Inhibitory Effect of Newly-Synthesized Chalcones on Hemolytic Activity of Methicillin-Resistant Staphylococcus aureus VL - 64 IS - 4 SP - 379 EP - 382 DO - 10.5604/17331331.1185237 ER -
@article{ author = "Božić, Dragana and Milenković, Marina and Ivković, Branka and Larsen, Anders Rhod and Cirković, Ivana", year = "2015", abstract = "Pathogenicity of methicillin-resistant Staphylococcus aureus (MRSA) is associated with a broad spectrum of virulence factors, amongst which is a-hemolysin. The aim of this study was to investigate the effect of three newly-synthesized chalcones (1,3- Bis-(2-hydroxy-phenyl)propenone, 3(3-Hydroxy-phenyl)-1-(2-hydroxy-phenyl)-propenone and 3-(4-Hydroxy-phenyl)-1-(2-hydroxy-phenyl)-propenone) on a-hemolysin production of clinical isolates of MRSA. Subinhibitory concentrations of the tested compounds reduced hemolytic activity of MRSA strains, with almost complete abolishment of hemolysis at concentrations in the range of 1/2-1/4 x MIC (25-12.5 mu g/ml). In conclusion, newly-synthesized chalcones tested in this study showed potent inhibitory activity on a-hemolysin production of multiresistant and genetically diverse MRSA strains.", publisher = "Polskie Towarzystwo Mikrobiologow-Polish Society Of Microbiologists, Warsaw", journal = "Polish Journal of Microbiology", title = "Inhibitory Effect of Newly-Synthesized Chalcones on Hemolytic Activity of Methicillin-Resistant Staphylococcus aureus", volume = "64", number = "4", pages = "379-382", doi = "10.5604/17331331.1185237" }
Božić, D., Milenković, M., Ivković, B., Larsen, A. R.,& Cirković, I.. (2015). Inhibitory Effect of Newly-Synthesized Chalcones on Hemolytic Activity of Methicillin-Resistant Staphylococcus aureus. in Polish Journal of Microbiology Polskie Towarzystwo Mikrobiologow-Polish Society Of Microbiologists, Warsaw., 64(4), 379-382. https://doi.org/10.5604/17331331.1185237
Božić D, Milenković M, Ivković B, Larsen AR, Cirković I. Inhibitory Effect of Newly-Synthesized Chalcones on Hemolytic Activity of Methicillin-Resistant Staphylococcus aureus. in Polish Journal of Microbiology. 2015;64(4):379-382. doi:10.5604/17331331.1185237 .
Božić, Dragana, Milenković, Marina, Ivković, Branka, Larsen, Anders Rhod, Cirković, Ivana, "Inhibitory Effect of Newly-Synthesized Chalcones on Hemolytic Activity of Methicillin-Resistant Staphylococcus aureus" in Polish Journal of Microbiology, 64, no. 4 (2015):379-382, https://doi.org/10.5604/17331331.1185237 . .