Phenolic profile and anti-inflammatory activity of three Veronica species
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2015
Authors
Beara, Ivana
Živković, Jelena
Lesjak, Marija

Ristić, Jelena

Šavikin, Katarina

Maksimović, Zoran

Janković, Teodora
Article (Published version)

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Aerial parts of some Veronica species are used as traditional medicine for treatment of various inflammatory conditions, including rheumatism. In the present study, phenolic content and anti-inflammatory activity of three Veronica species (Plantaginaceae), Veronica jacquinii Baumg., Veronica teucrium L. and Veronica urticifolia Jacq was studied. The identification and quantification of 30 phenolic compounds in aqueous-acetone extracts were performed using LC-MS/MS technique, and the main components were baicalin, hyperoside, isoquercetine, chlorogenic acid and quinic acid. Genistein and baicalein were detected for the first time in Plantaginaceae family and Veronica genus, respectively. The anti-inflammatory potential of tested extracts was determined using calcium ionophore-stimulated human platelets as a source of cyclooxygenase-1 (COX-1) and 12-lipoxygenase (12-LOX) enzymes, and highly sensitive and specific LC-MS/MS technique was performed for detection of the main arachidonic acid... metabolites formed by them. V. urticifolia extract exerted the strongest COX-1 inhibition (IC50 lt 0.4 mg/mL), while V. jacquinii extract exhibited the highest ability to inhibit 12-LOX activity (IC50 = 1.072 mg/mL). The results obtained in this study may be used to promote better use of the genus Veronica as anti-inflammatory agents.
Keywords:
Veronica species / Phenolics / Anti-inflammation / LC-MS/MSSource:
Industrial Crops and Products, 2015, 63, 276-280Publisher:
- Elsevier Science BV, Amsterdam
Funding / projects:
DOI: 10.1016/j.indcrop.2014.09.034
ISSN: 0926-6690
WoS: 000347499000038
Scopus: 2-s2.0-84922357965
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PharmacyTY - JOUR AU - Beara, Ivana AU - Živković, Jelena AU - Lesjak, Marija AU - Ristić, Jelena AU - Šavikin, Katarina AU - Maksimović, Zoran AU - Janković, Teodora PY - 2015 UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2377 AB - Aerial parts of some Veronica species are used as traditional medicine for treatment of various inflammatory conditions, including rheumatism. In the present study, phenolic content and anti-inflammatory activity of three Veronica species (Plantaginaceae), Veronica jacquinii Baumg., Veronica teucrium L. and Veronica urticifolia Jacq was studied. The identification and quantification of 30 phenolic compounds in aqueous-acetone extracts were performed using LC-MS/MS technique, and the main components were baicalin, hyperoside, isoquercetine, chlorogenic acid and quinic acid. Genistein and baicalein were detected for the first time in Plantaginaceae family and Veronica genus, respectively. The anti-inflammatory potential of tested extracts was determined using calcium ionophore-stimulated human platelets as a source of cyclooxygenase-1 (COX-1) and 12-lipoxygenase (12-LOX) enzymes, and highly sensitive and specific LC-MS/MS technique was performed for detection of the main arachidonic acid metabolites formed by them. V. urticifolia extract exerted the strongest COX-1 inhibition (IC50 lt 0.4 mg/mL), while V. jacquinii extract exhibited the highest ability to inhibit 12-LOX activity (IC50 = 1.072 mg/mL). The results obtained in this study may be used to promote better use of the genus Veronica as anti-inflammatory agents. PB - Elsevier Science BV, Amsterdam T2 - Industrial Crops and Products T1 - Phenolic profile and anti-inflammatory activity of three Veronica species VL - 63 SP - 276 EP - 280 DO - 10.1016/j.indcrop.2014.09.034 ER -
@article{ author = "Beara, Ivana and Živković, Jelena and Lesjak, Marija and Ristić, Jelena and Šavikin, Katarina and Maksimović, Zoran and Janković, Teodora", year = "2015", abstract = "Aerial parts of some Veronica species are used as traditional medicine for treatment of various inflammatory conditions, including rheumatism. In the present study, phenolic content and anti-inflammatory activity of three Veronica species (Plantaginaceae), Veronica jacquinii Baumg., Veronica teucrium L. and Veronica urticifolia Jacq was studied. The identification and quantification of 30 phenolic compounds in aqueous-acetone extracts were performed using LC-MS/MS technique, and the main components were baicalin, hyperoside, isoquercetine, chlorogenic acid and quinic acid. Genistein and baicalein were detected for the first time in Plantaginaceae family and Veronica genus, respectively. The anti-inflammatory potential of tested extracts was determined using calcium ionophore-stimulated human platelets as a source of cyclooxygenase-1 (COX-1) and 12-lipoxygenase (12-LOX) enzymes, and highly sensitive and specific LC-MS/MS technique was performed for detection of the main arachidonic acid metabolites formed by them. V. urticifolia extract exerted the strongest COX-1 inhibition (IC50 lt 0.4 mg/mL), while V. jacquinii extract exhibited the highest ability to inhibit 12-LOX activity (IC50 = 1.072 mg/mL). The results obtained in this study may be used to promote better use of the genus Veronica as anti-inflammatory agents.", publisher = "Elsevier Science BV, Amsterdam", journal = "Industrial Crops and Products", title = "Phenolic profile and anti-inflammatory activity of three Veronica species", volume = "63", pages = "276-280", doi = "10.1016/j.indcrop.2014.09.034" }
Beara, I., Živković, J., Lesjak, M., Ristić, J., Šavikin, K., Maksimović, Z.,& Janković, T.. (2015). Phenolic profile and anti-inflammatory activity of three Veronica species. in Industrial Crops and Products Elsevier Science BV, Amsterdam., 63, 276-280. https://doi.org/10.1016/j.indcrop.2014.09.034
Beara I, Živković J, Lesjak M, Ristić J, Šavikin K, Maksimović Z, Janković T. Phenolic profile and anti-inflammatory activity of three Veronica species. in Industrial Crops and Products. 2015;63:276-280. doi:10.1016/j.indcrop.2014.09.034 .
Beara, Ivana, Živković, Jelena, Lesjak, Marija, Ristić, Jelena, Šavikin, Katarina, Maksimović, Zoran, Janković, Teodora, "Phenolic profile and anti-inflammatory activity of three Veronica species" in Industrial Crops and Products, 63 (2015):276-280, https://doi.org/10.1016/j.indcrop.2014.09.034 . .