Show simple item record

dc.creatorVemić, Ana
dc.creatorKalinić, Marko
dc.creatorErić, Slavica
dc.creatorMalenović, Anđelija
dc.creatorMedenica, Mirjana
dc.date.accessioned2019-09-02T11:46:34Z
dc.date.available2019-09-02T11:46:34Z
dc.date.issued2015
dc.identifier.issn0021-9673
dc.identifier.urihttp://farfar.pharmacy.bg.ac.rs/handle/123456789/2383
dc.description.abstractThe aim of this study was to examine the interaction of the chaotropic salts of different position in Hofmeister series (CF3COONa, NaClO4, NaPF6) added to the mobile phase with the stationary phases of different hydrophobicity (C8 and C18 XTerra (R) columns), as well as their common influence on the retention behavior of pramipexole and its structurally related impurities. The extended thermodynamic approach enabled the understanding of the underlying separation mechanism. Comparing six different column-salt systems it was observed that general system hydrophobicity presented by salt chaotropicity and column hydrophobicity favors stationary phase ion-pairing over the ion-pair formation in the eluent. Further, an attempt was made to describe the influence of analytes' nature on their retention behavior in such chromatographic systems. An analysis is performed in order to select and elucidate the molecular descriptors (electrostatical, quantum-chemical, geometrical, topological, and constitutional) that best explain the experimental evidence and findings obtained by the thermodynamic approach. The results of this analysis suggest that analytes' charge distribution and its complementarity to the structure of the electric double layer formed on the surface of the stationary phase upon the addition of chaotropic additives can be useful for understanding the differences in retention of structurally related analytes. These findings provide a novel understanding of the interactions between all the components of the chromatographic system containing chaotropic additive and a good basis for further investigations suggesting the development of generally applicable predictors in structure-retention relationship studies in related chromatographic systems.en
dc.publisherElsevier Science BV, Amsterdam
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/172052/RS//
dc.rightsrestrictedAccess
dc.sourceJournal of Chromatography A
dc.subjectChaotropic saltsen
dc.subjectColumn hydrophobicityen
dc.subjectThermodynamic approachen
dc.subjectMolecular descriptorsen
dc.subjectPramipexoleen
dc.titleThe influence of salt chaotropicity, column hydrophobicity and analytes' molecular properties on the retention of pramipexole and its impuritiesen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractВемић, Aна; Ерић, Славица; Маленовић, Aнђелија; Меденица, Мирјана; Калинић, Марко;
dc.citation.volume1386
dc.citation.spage39
dc.citation.epage46
dc.citation.other1386: 39-46
dc.citation.rankM21
dc.identifier.wos000350930200005
dc.identifier.doi10.1016/j.chroma.2015.01.078
dc.identifier.pmid25681830
dc.identifier.scopus2-s2.0-84924608264
dc.identifier.rcubconv_3277
dc.type.versionpublishedVersion


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record