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dc.creatorTopalović, Dijana
dc.creatorŽivković, Lada
dc.creatorPirković, Andrea
dc.creatorĐelić, Ninoslav
dc.creatorBajić, Vladan
dc.creatorDekanski, Dragana
dc.creatorPotparević, Biljana
dc.date.accessioned2019-09-02T11:46:34Z
dc.date.available2019-09-02T11:46:34Z
dc.date.issued2015
dc.identifier.issn1942-0900
dc.identifier.urihttp://farfar.pharmacy.bg.ac.rs/handle/123456789/2384
dc.description.abstractThe thyroid hormones change the rate of basal metabolism, modulating the consumption of oxygen and causing production of reactive oxygen species, which leads to the development of oxidative stress and DNA strand breaks. Olive (Olea europaea L.) leaf contains many potentially bioactive compounds, making it one of the most potent natural antioxidants. The objective of this study was to evaluate the genotoxicity of L-thyroxine and to investigate antioxidative and antigenotoxic potential of the standardized oleuropein-rich dry olive leaf extract (DOLE) against hydrogen peroxide and L-thyroxine-induced DNA damage in human peripheral blood leukocytes by using the comet assay. Various concentrations of the extract were tested with both DNA damage inducers, under two different experimental conditions, pretreatment and posttreatment. Results indicate that L-thyroxine exhibited genotoxic effect and that DOLE displayed protective effect against thyroxine-induced genotoxicity. The number of cells with DNA damage, was significantly reduced, in both pretreated and posttreated samples (P lt 0.05). Comparing the beneficial effect of all tested concentrations of DOLE, in both experimental protocols, it appears that extract was more effective in reducing DNA damage in the pretreatment, exhibiting protective role against L-thyroxine effect. This feature of DOLE can be explained by its capacity to act as potent free radical scavenger.en
dc.publisherHindawi Ltd, London
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/173034/RS//
dc.rightsopenAccess
dc.sourceOxidative Medicine and Cellular Longevity
dc.titleDry Olive Leaf Extract Counteracts L-Thyroxine-Induced Genotoxicity in Human Peripheral Blood Leukocytes In Vitroen
dc.typearticle
dc.rights.licenseBY
dcterms.abstractБајић, Владан; Топаловић, Дијана; Потпаревић, Биљана; Декански, Драгана; Ђелић, Нинослав; Пирковић, Aндреа; Живковић, Лада;
dc.citation.rankM21
dc.identifier.wos000350664000001
dc.identifier.doi10.1155/2015/762192
dc.identifier.pmid25789081
dc.identifier.scopus2-s2.0-84924249662
dc.identifier.fulltexthttp://farfar.pharmacy.bg.ac.rs//bitstream/id/1075/2382.pdf
dc.identifier.rcubconv_3276
dc.type.versionpublishedVersion


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