Skewed X-Chromosome Inactivation in Women Affected by Alzheimer's Disease
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2015
Authors
Bajić, VladanMandusić, Vesna
Stefanova, Elka
Bozović, Ana
Davidović, Radoslav
Živković, Lada
Pirković, Andrea
Potparević, Biljana
Article (Published version)
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Show full item recordAbstract
X-chromosome instability has been a long established feature in Alzheimer's disease ( AD). Premature centromere division and aneuploidy of the X-chromosome has been found in peripheral blood lymphocytes and neuronal tissue in female AD patients. Interestingly, only one chromosome of the X pair has been affected. These results raised a question, "Is the X-chromosome inactivation pattern altered in peripheral blood lymphocytes ofwomen affected by AD?" To address this question, we analyzed the methylation status of androgen receptor promoter which may show us any deviation from the 50 : 50% X inactivation status in peripheral blood lymphocytes ofwomen with AD. Our results showed skewed inactivation patterns (>90%). These findings suggest that an epigenetic alteration on the inactivation centers of the X-chromosome (or skewing) relates not only to aging, by might be a novel property that could account for the higher incidence of AD in women.
Keywords:
Alzheimer's disease / aneuploidy / methylation specific qPCR / X-chromosome / X-chromosome skewingSource:
Journal of Alzheimers Disease, 2015, 43, 4, 1251-1259Publisher:
- Ios Press, Amsterdam
Funding / projects:
- Cell Cycle Aberrations and the Impact of Oxidative Stress in Neurodegenerative Processes and Malignant Transformation of the Cell (RS-MESTD-Basic Research (BR or ON)-173034)
DOI: 10.3233/JAD-141674
ISSN: 1387-2877
PubMed: 25159673
WoS: 000346857400014
Scopus: 2-s2.0-84919880287
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Institution/Community
PharmacyTY - JOUR AU - Bajić, Vladan AU - Mandusić, Vesna AU - Stefanova, Elka AU - Bozović, Ana AU - Davidović, Radoslav AU - Živković, Lada AU - Pirković, Andrea AU - Potparević, Biljana PY - 2015 UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2386 AB - X-chromosome instability has been a long established feature in Alzheimer's disease ( AD). Premature centromere division and aneuploidy of the X-chromosome has been found in peripheral blood lymphocytes and neuronal tissue in female AD patients. Interestingly, only one chromosome of the X pair has been affected. These results raised a question, "Is the X-chromosome inactivation pattern altered in peripheral blood lymphocytes ofwomen affected by AD?" To address this question, we analyzed the methylation status of androgen receptor promoter which may show us any deviation from the 50 : 50% X inactivation status in peripheral blood lymphocytes ofwomen with AD. Our results showed skewed inactivation patterns (>90%). These findings suggest that an epigenetic alteration on the inactivation centers of the X-chromosome (or skewing) relates not only to aging, by might be a novel property that could account for the higher incidence of AD in women. PB - Ios Press, Amsterdam T2 - Journal of Alzheimers Disease T1 - Skewed X-Chromosome Inactivation in Women Affected by Alzheimer's Disease VL - 43 IS - 4 SP - 1251 EP - 1259 DO - 10.3233/JAD-141674 ER -
@article{ author = "Bajić, Vladan and Mandusić, Vesna and Stefanova, Elka and Bozović, Ana and Davidović, Radoslav and Živković, Lada and Pirković, Andrea and Potparević, Biljana", year = "2015", abstract = "X-chromosome instability has been a long established feature in Alzheimer's disease ( AD). Premature centromere division and aneuploidy of the X-chromosome has been found in peripheral blood lymphocytes and neuronal tissue in female AD patients. Interestingly, only one chromosome of the X pair has been affected. These results raised a question, "Is the X-chromosome inactivation pattern altered in peripheral blood lymphocytes ofwomen affected by AD?" To address this question, we analyzed the methylation status of androgen receptor promoter which may show us any deviation from the 50 : 50% X inactivation status in peripheral blood lymphocytes ofwomen with AD. Our results showed skewed inactivation patterns (>90%). These findings suggest that an epigenetic alteration on the inactivation centers of the X-chromosome (or skewing) relates not only to aging, by might be a novel property that could account for the higher incidence of AD in women.", publisher = "Ios Press, Amsterdam", journal = "Journal of Alzheimers Disease", title = "Skewed X-Chromosome Inactivation in Women Affected by Alzheimer's Disease", volume = "43", number = "4", pages = "1251-1259", doi = "10.3233/JAD-141674" }
Bajić, V., Mandusić, V., Stefanova, E., Bozović, A., Davidović, R., Živković, L., Pirković, A.,& Potparević, B.. (2015). Skewed X-Chromosome Inactivation in Women Affected by Alzheimer's Disease. in Journal of Alzheimers Disease Ios Press, Amsterdam., 43(4), 1251-1259. https://doi.org/10.3233/JAD-141674
Bajić V, Mandusić V, Stefanova E, Bozović A, Davidović R, Živković L, Pirković A, Potparević B. Skewed X-Chromosome Inactivation in Women Affected by Alzheimer's Disease. in Journal of Alzheimers Disease. 2015;43(4):1251-1259. doi:10.3233/JAD-141674 .
Bajić, Vladan, Mandusić, Vesna, Stefanova, Elka, Bozović, Ana, Davidović, Radoslav, Živković, Lada, Pirković, Andrea, Potparević, Biljana, "Skewed X-Chromosome Inactivation in Women Affected by Alzheimer's Disease" in Journal of Alzheimers Disease, 43, no. 4 (2015):1251-1259, https://doi.org/10.3233/JAD-141674 . .