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dc.creatorBajić, Vladan
dc.creatorMandusić, Vesna
dc.creatorStefanova, Elka
dc.creatorBozović, Ana
dc.creatorDavidović, Radoslav
dc.creatorŽivković, Lada
dc.creatorPirković, Andrea
dc.creatorPotparević, Biljana
dc.date.accessioned2019-09-02T11:46:36Z
dc.date.available2019-09-02T11:46:36Z
dc.date.issued2015
dc.identifier.issn1387-2877
dc.identifier.urihttp://farfar.pharmacy.bg.ac.rs/handle/123456789/2386
dc.description.abstractX-chromosome instability has been a long established feature in Alzheimer's disease ( AD). Premature centromere division and aneuploidy of the X-chromosome has been found in peripheral blood lymphocytes and neuronal tissue in female AD patients. Interestingly, only one chromosome of the X pair has been affected. These results raised a question, "Is the X-chromosome inactivation pattern altered in peripheral blood lymphocytes ofwomen affected by AD?" To address this question, we analyzed the methylation status of androgen receptor promoter which may show us any deviation from the 50 : 50% X inactivation status in peripheral blood lymphocytes ofwomen with AD. Our results showed skewed inactivation patterns (>90%). These findings suggest that an epigenetic alteration on the inactivation centers of the X-chromosome (or skewing) relates not only to aging, by might be a novel property that could account for the higher incidence of AD in women.en
dc.publisherIos Press, Amsterdam
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/173034/RS//
dc.rightsrestrictedAccess
dc.sourceJournal of Alzheimers Disease
dc.subjectAlzheimer's diseaseen
dc.subjectaneuploidyen
dc.subjectmethylation specific qPCRen
dc.subjectX-chromosomeen
dc.subjectX-chromosome skewingen
dc.titleSkewed X-Chromosome Inactivation in Women Affected by Alzheimer's Diseaseen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractСтефанова, Елка; Потпаревић, Биљана; Бозовић, Aна; Давидовић, Радослав; Мандусић, Весна; Бајић, Владан; Живковић, Лада; Пирковић, Aндреа;
dc.citation.volume43
dc.citation.issue4
dc.citation.spage1251
dc.citation.epage1259
dc.citation.other43(4): 1251-1259
dc.citation.rankM21
dc.identifier.wos000346857400014
dc.identifier.doi10.3233/JAD-141674
dc.identifier.pmid25159673
dc.identifier.scopus2-s2.0-84919880287
dc.identifier.rcubconv_3222
dc.type.versionpublishedVersion


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