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Determination of Moxonidine and Its Impurities by Thin-Layer Chromatography

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Authors
Filipić, Slavica
Shenger, Musbah Salem Mohamed
Nikolić, Katarina
Agbaba, Danica
Article (Published version)
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Abstract
A thin-layer chromatographic method for simultaneous determination of moxonidine and its four impurities was developed and validated. Separation of the examined compounds was performed on chromatographic plates precoated with silica gel 60F(254) and using methanol-toluene-dichloroethane-ammonia 2:3:3:0.1 (v/v/v/v) as mobile phase. Ascending development mode was performed in the twin-trough chromatographic chamber, which was presaturated with mobile phase vapors for 15min. The developed chromatographic plates were dried in air and densitometrically scanned at the wavelengths of 260 and 280nm. Regression coefficients (r >= 0.998), recovery (90.10-107.63%), limit of quantification of impurities (20ng band(-1) equivalent to the 0.12% impurity level), and robustness were validated and found satisfactory. The developed method is well suited for quantitative analysis and purity control of moxonidine in its dosage forms.
Keywords:
pharmaceuticals / moxonidine / method validation / quantitation / impurities / TLC
Source:
Journal of Liquid Chromatography & Related Technologies, 2015, 38, 11, 1121-1125
Publisher:
  • Taylor & Francis Inc, Philadelphia
Funding / projects:
  • Synthesis, Quantitative Structure and Activity Relationship, Physico-Chemical Characterisation and Analysis of Pharmacologically Active Substances (RS-172033)
Note:
  • Peer-reviewed manuscript: http://farfar.pharmacy.bg.ac.rs/handle/123456789/3439

DOI: 10.1080/10826076.2015.1028291

ISSN: 1082-6076

WoS: 000354045900006

Scopus: 2-s2.0-84929231814
[ Google Scholar ]
3
2
URI
https://farfar.pharmacy.bg.ac.rs/handle/123456789/2391
Collections
  • Radovi istraživača / Researchers’ publications
Institution/Community
Pharmacy
TY  - JOUR
AU  - Filipić, Slavica
AU  - Shenger, Musbah Salem Mohamed
AU  - Nikolić, Katarina
AU  - Agbaba, Danica
PY  - 2015
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2391
AB  - A thin-layer chromatographic method for simultaneous determination of moxonidine and its four impurities was developed and validated. Separation of the examined compounds was performed on chromatographic plates precoated with silica gel 60F(254) and using methanol-toluene-dichloroethane-ammonia 2:3:3:0.1 (v/v/v/v) as mobile phase. Ascending development mode was performed in the twin-trough chromatographic chamber, which was presaturated with mobile phase vapors for 15min. The developed chromatographic plates were dried in air and densitometrically scanned at the wavelengths of 260 and 280nm. Regression coefficients (r >= 0.998), recovery (90.10-107.63%), limit of quantification of impurities (20ng band(-1) equivalent to the 0.12% impurity level), and robustness were validated and found satisfactory. The developed method is well suited for quantitative analysis and purity control of moxonidine in its dosage forms.
PB  - Taylor & Francis Inc, Philadelphia
T2  - Journal of Liquid Chromatography & Related Technologies
T1  - Determination of Moxonidine and Its Impurities by Thin-Layer Chromatography
VL  - 38
IS  - 11
SP  - 1121
EP  - 1125
DO  - 10.1080/10826076.2015.1028291
ER  - 
@article{
author = "Filipić, Slavica and Shenger, Musbah Salem Mohamed and Nikolić, Katarina and Agbaba, Danica",
year = "2015",
abstract = "A thin-layer chromatographic method for simultaneous determination of moxonidine and its four impurities was developed and validated. Separation of the examined compounds was performed on chromatographic plates precoated with silica gel 60F(254) and using methanol-toluene-dichloroethane-ammonia 2:3:3:0.1 (v/v/v/v) as mobile phase. Ascending development mode was performed in the twin-trough chromatographic chamber, which was presaturated with mobile phase vapors for 15min. The developed chromatographic plates were dried in air and densitometrically scanned at the wavelengths of 260 and 280nm. Regression coefficients (r >= 0.998), recovery (90.10-107.63%), limit of quantification of impurities (20ng band(-1) equivalent to the 0.12% impurity level), and robustness were validated and found satisfactory. The developed method is well suited for quantitative analysis and purity control of moxonidine in its dosage forms.",
publisher = "Taylor & Francis Inc, Philadelphia",
journal = "Journal of Liquid Chromatography & Related Technologies",
title = "Determination of Moxonidine and Its Impurities by Thin-Layer Chromatography",
volume = "38",
number = "11",
pages = "1121-1125",
doi = "10.1080/10826076.2015.1028291"
}
Filipić, S., Shenger, M. S. M., Nikolić, K.,& Agbaba, D.. (2015). Determination of Moxonidine and Its Impurities by Thin-Layer Chromatography. in Journal of Liquid Chromatography & Related Technologies
Taylor & Francis Inc, Philadelphia., 38(11), 1121-1125.
https://doi.org/10.1080/10826076.2015.1028291
Filipić S, Shenger MSM, Nikolić K, Agbaba D. Determination of Moxonidine and Its Impurities by Thin-Layer Chromatography. in Journal of Liquid Chromatography & Related Technologies. 2015;38(11):1121-1125.
doi:10.1080/10826076.2015.1028291 .
Filipić, Slavica, Shenger, Musbah Salem Mohamed, Nikolić, Katarina, Agbaba, Danica, "Determination of Moxonidine and Its Impurities by Thin-Layer Chromatography" in Journal of Liquid Chromatography & Related Technologies, 38, no. 11 (2015):1121-1125,
https://doi.org/10.1080/10826076.2015.1028291 . .

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