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Patterns and factors associated with low adherence to psychotropic medications during pregnancy - A cross-sectional, multinational web-based study

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2015
Authors
Lupattelli, Angela
Spigset, Olav
Bjoernsdottir, Ingunn
Haemeen-Anttila, Katri
Mardby, Ann-Charlotte
Panchaud, Alice
Juraski, Romana Gjergja
Rudolf, Gorazd
Odalović, Marina
Drozd, Mariola
Twigg, Michael J.
Juch, Herbert
Moretti, Myla E.
Kennedy, Debra
Rieutord, Andre
Zagorodnikova, Ksenia
Passier, Anneke
Nordeng, Hedvig
Article (Published version)
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Abstract
BackgroundNo previous studies have explored how closely women follow their psychotropic drug regimens during pregnancy. This study aimed to explore patterns of and factors associated with low adherence to psychotropic medication during pregnancy. MethodsMultinational web-based study was performed in 18 countries in Europe, North America, and Australia. Uniform data collection was ensured via an electronic questionnaire. Pregnant women were eligible to participate. Adherence was measured via the 8-item Morisky Medication Adherence Scale (MMAS-8). The Beliefs about Prescribed Medicines Questionnaire (BMQ-specific), the Edinburgh Postnatal Depression Scale (EPDS), and a numeric rating scale were utilized to measure women's beliefs, depressive symptoms, and antidepressant risk perception, respectively. Participants reporting use of psychotropic medication during pregnancy (n = 160) were included in the analysis. ResultsOn the basis of the MMAS-8, 78 of 160 women (48.8%, 95% CI: 41.1-56.4%)... demonstrated low adherence during pregnancy. The rates of low adherence were 51.3% for medication for anxiety, 47.2% for depression, and 42.9% for other psychiatric disorders. Smoking during pregnancy, elevated antidepressant risk perception (risk6), and depressive symptoms were associated with a significant 3.9-, 2.3-, and 2.5-fold increased likelihood of low medication adherence, respectively. Women on psychotropic polytherapy were less likely to demonstrate low adherence. The belief that the benefit of pharmacotherapy outweighed the risks positively correlated (r = .282) with higher medication adherence. ConclusionsApproximately one of two pregnant women using psychotropic medication demonstrated low adherence in pregnancy. Life-style factors, risk perception, depressive symptoms, and individual beliefs are important factors related to adherence to psychotropic medication in pregnancy.

Keywords:
adherence / pharmacotherapy / antidepressants / depression / anxiety / pregnancy
Source:
Depression and Anxiety, 2015, 32, 6, 426-436
Publisher:
  • Wiley, Hoboken

DOI: 10.1002/da.22352

ISSN: 1091-4269

PubMed: 25703355

WoS: 000354568500006

Scopus: 2-s2.0-84929504965
[ Google Scholar ]
29
30
URI
http://farfar.pharmacy.bg.ac.rs/handle/123456789/2397
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  • Radovi istraživača / Researchers’ publications
Institution
Pharmacy

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