Patterns and factors associated with low adherence to psychotropic medications during pregnancy - A cross-sectional, multinational web-based study
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2015
Authors
Lupattelli, Angela
Spigset, Olav
Bjoernsdottir, Ingunn
Haemeen-Anttila, Katri
Mardby, Ann-Charlotte

Panchaud, Alice

Juraski, Romana Gjergja
Rudolf, Gorazd
Odalović, Marina

Drozd, Mariola

Twigg, Michael J.

Juch, Herbert
Moretti, Myla E.
Kennedy, Debra
Rieutord, Andre

Zagorodnikova, Ksenia

Passier, Anneke
Nordeng, Hedvig
Article (Published version)

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BackgroundNo previous studies have explored how closely women follow their psychotropic drug regimens during pregnancy. This study aimed to explore patterns of and factors associated with low adherence to psychotropic medication during pregnancy. MethodsMultinational web-based study was performed in 18 countries in Europe, North America, and Australia. Uniform data collection was ensured via an electronic questionnaire. Pregnant women were eligible to participate. Adherence was measured via the 8-item Morisky Medication Adherence Scale (MMAS-8). The Beliefs about Prescribed Medicines Questionnaire (BMQ-specific), the Edinburgh Postnatal Depression Scale (EPDS), and a numeric rating scale were utilized to measure women's beliefs, depressive symptoms, and antidepressant risk perception, respectively. Participants reporting use of psychotropic medication during pregnancy (n = 160) were included in the analysis. ResultsOn the basis of the MMAS-8, 78 of 160 women (48.8%, 95% CI: 41.1-56.4%)... demonstrated low adherence during pregnancy. The rates of low adherence were 51.3% for medication for anxiety, 47.2% for depression, and 42.9% for other psychiatric disorders. Smoking during pregnancy, elevated antidepressant risk perception (risk6), and depressive symptoms were associated with a significant 3.9-, 2.3-, and 2.5-fold increased likelihood of low medication adherence, respectively. Women on psychotropic polytherapy were less likely to demonstrate low adherence. The belief that the benefit of pharmacotherapy outweighed the risks positively correlated (r = .282) with higher medication adherence. ConclusionsApproximately one of two pregnant women using psychotropic medication demonstrated low adherence in pregnancy. Life-style factors, risk perception, depressive symptoms, and individual beliefs are important factors related to adherence to psychotropic medication in pregnancy.
Keywords:
adherence / pharmacotherapy / antidepressants / depression / anxiety / pregnancySource:
Depression and Anxiety, 2015, 32, 6, 426-436Publisher:
- Wiley, Hoboken
DOI: 10.1002/da.22352
ISSN: 1091-4269
PubMed: 25703355
WoS: 000354568500006
Scopus: 2-s2.0-84929504965
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PharmacyTY - JOUR AU - Lupattelli, Angela AU - Spigset, Olav AU - Bjoernsdottir, Ingunn AU - Haemeen-Anttila, Katri AU - Mardby, Ann-Charlotte AU - Panchaud, Alice AU - Juraski, Romana Gjergja AU - Rudolf, Gorazd AU - Odalović, Marina AU - Drozd, Mariola AU - Twigg, Michael J. AU - Juch, Herbert AU - Moretti, Myla E. AU - Kennedy, Debra AU - Rieutord, Andre AU - Zagorodnikova, Ksenia AU - Passier, Anneke AU - Nordeng, Hedvig PY - 2015 UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2397 AB - BackgroundNo previous studies have explored how closely women follow their psychotropic drug regimens during pregnancy. This study aimed to explore patterns of and factors associated with low adherence to psychotropic medication during pregnancy. MethodsMultinational web-based study was performed in 18 countries in Europe, North America, and Australia. Uniform data collection was ensured via an electronic questionnaire. Pregnant women were eligible to participate. Adherence was measured via the 8-item Morisky Medication Adherence Scale (MMAS-8). The Beliefs about Prescribed Medicines Questionnaire (BMQ-specific), the Edinburgh Postnatal Depression Scale (EPDS), and a numeric rating scale were utilized to measure women's beliefs, depressive symptoms, and antidepressant risk perception, respectively. Participants reporting use of psychotropic medication during pregnancy (n = 160) were included in the analysis. ResultsOn the basis of the MMAS-8, 78 of 160 women (48.8%, 95% CI: 41.1-56.4%) demonstrated low adherence during pregnancy. The rates of low adherence were 51.3% for medication for anxiety, 47.2% for depression, and 42.9% for other psychiatric disorders. Smoking during pregnancy, elevated antidepressant risk perception (risk6), and depressive symptoms were associated with a significant 3.9-, 2.3-, and 2.5-fold increased likelihood of low medication adherence, respectively. Women on psychotropic polytherapy were less likely to demonstrate low adherence. The belief that the benefit of pharmacotherapy outweighed the risks positively correlated (r = .282) with higher medication adherence. ConclusionsApproximately one of two pregnant women using psychotropic medication demonstrated low adherence in pregnancy. Life-style factors, risk perception, depressive symptoms, and individual beliefs are important factors related to adherence to psychotropic medication in pregnancy. PB - Wiley, Hoboken T2 - Depression and Anxiety T1 - Patterns and factors associated with low adherence to psychotropic medications during pregnancy - A cross-sectional, multinational web-based study VL - 32 IS - 6 SP - 426 EP - 436 DO - 10.1002/da.22352 ER -
@article{ author = "Lupattelli, Angela and Spigset, Olav and Bjoernsdottir, Ingunn and Haemeen-Anttila, Katri and Mardby, Ann-Charlotte and Panchaud, Alice and Juraski, Romana Gjergja and Rudolf, Gorazd and Odalović, Marina and Drozd, Mariola and Twigg, Michael J. and Juch, Herbert and Moretti, Myla E. and Kennedy, Debra and Rieutord, Andre and Zagorodnikova, Ksenia and Passier, Anneke and Nordeng, Hedvig", year = "2015", abstract = "BackgroundNo previous studies have explored how closely women follow their psychotropic drug regimens during pregnancy. This study aimed to explore patterns of and factors associated with low adherence to psychotropic medication during pregnancy. MethodsMultinational web-based study was performed in 18 countries in Europe, North America, and Australia. Uniform data collection was ensured via an electronic questionnaire. Pregnant women were eligible to participate. Adherence was measured via the 8-item Morisky Medication Adherence Scale (MMAS-8). The Beliefs about Prescribed Medicines Questionnaire (BMQ-specific), the Edinburgh Postnatal Depression Scale (EPDS), and a numeric rating scale were utilized to measure women's beliefs, depressive symptoms, and antidepressant risk perception, respectively. Participants reporting use of psychotropic medication during pregnancy (n = 160) were included in the analysis. ResultsOn the basis of the MMAS-8, 78 of 160 women (48.8%, 95% CI: 41.1-56.4%) demonstrated low adherence during pregnancy. The rates of low adherence were 51.3% for medication for anxiety, 47.2% for depression, and 42.9% for other psychiatric disorders. Smoking during pregnancy, elevated antidepressant risk perception (risk6), and depressive symptoms were associated with a significant 3.9-, 2.3-, and 2.5-fold increased likelihood of low medication adherence, respectively. Women on psychotropic polytherapy were less likely to demonstrate low adherence. The belief that the benefit of pharmacotherapy outweighed the risks positively correlated (r = .282) with higher medication adherence. ConclusionsApproximately one of two pregnant women using psychotropic medication demonstrated low adherence in pregnancy. Life-style factors, risk perception, depressive symptoms, and individual beliefs are important factors related to adherence to psychotropic medication in pregnancy.", publisher = "Wiley, Hoboken", journal = "Depression and Anxiety", title = "Patterns and factors associated with low adherence to psychotropic medications during pregnancy - A cross-sectional, multinational web-based study", volume = "32", number = "6", pages = "426-436", doi = "10.1002/da.22352" }
Lupattelli, A., Spigset, O., Bjoernsdottir, I., Haemeen-Anttila, K., Mardby, A., Panchaud, A., Juraski, R. G., Rudolf, G., Odalović, M., Drozd, M., Twigg, M. J., Juch, H., Moretti, M. E., Kennedy, D., Rieutord, A., Zagorodnikova, K., Passier, A.,& Nordeng, H.. (2015). Patterns and factors associated with low adherence to psychotropic medications during pregnancy - A cross-sectional, multinational web-based study. in Depression and Anxiety Wiley, Hoboken., 32(6), 426-436. https://doi.org/10.1002/da.22352
Lupattelli A, Spigset O, Bjoernsdottir I, Haemeen-Anttila K, Mardby A, Panchaud A, Juraski RG, Rudolf G, Odalović M, Drozd M, Twigg MJ, Juch H, Moretti ME, Kennedy D, Rieutord A, Zagorodnikova K, Passier A, Nordeng H. Patterns and factors associated with low adherence to psychotropic medications during pregnancy - A cross-sectional, multinational web-based study. in Depression and Anxiety. 2015;32(6):426-436. doi:10.1002/da.22352 .
Lupattelli, Angela, Spigset, Olav, Bjoernsdottir, Ingunn, Haemeen-Anttila, Katri, Mardby, Ann-Charlotte, Panchaud, Alice, Juraski, Romana Gjergja, Rudolf, Gorazd, Odalović, Marina, Drozd, Mariola, Twigg, Michael J., Juch, Herbert, Moretti, Myla E., Kennedy, Debra, Rieutord, Andre, Zagorodnikova, Ksenia, Passier, Anneke, Nordeng, Hedvig, "Patterns and factors associated with low adherence to psychotropic medications during pregnancy - A cross-sectional, multinational web-based study" in Depression and Anxiety, 32, no. 6 (2015):426-436, https://doi.org/10.1002/da.22352 . .