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dc.creatorIvanović, Nevena
dc.creatorMinić, Rajna
dc.creatorĐuričić, Ivana
dc.creatorDimitrijević, Ljiljana
dc.creatorŠobajić, Slađana
dc.creatorŽivković, Irena
dc.creatorĐorđević, Brižita
dc.date.accessioned2019-09-02T11:46:58Z
dc.date.available2019-09-02T11:46:58Z
dc.date.issued2015
dc.identifier.issn0963-7486
dc.identifier.urihttps://farfar.pharmacy.bg.ac.rs/handle/123456789/2399
dc.description.abstractRecent reports suggest that the metabolic activity of the enteric microbiota may influence the fatty acid composition of the host tissue. There are many studies dealing with the influence of lactobacilli on various pathological conditions, and some of the effects are strain-specific. This study was designed to test the effects of a particular Lactobacillus strain, Lactobacillus rhamnosus LA68 on fatty acid composition of the liver and the brain of C57BL/6 mice in the absence of an underlying pathological condition. Female mice were supplemented with live L. rhamnosus LA68 bacteria for the duration of 1 month. Serum biochemistry was analyzed and liver and brain fatty acid composition was assessed by gas-liquid chromatography. Significant changes in liver and brain fatty acid composition were detected. In the liver tissue we detected an increase in palmitoleic acid (p = 0.038), while in the brain compartment we found an increase in palmitic (p = 0.042), stearic (p = 0.017), arachidonic acid (p = 0.009) and docosahexaenoic acid (p = 0.004) for control versus experimental group. These results show discrete changes caused by LA68 strain consumption. Even short duration of administration of LA68 influences the fatty acid composition of the host which adds to the existing knowledge about Lactobacillus host interaction, and adds to the growing knowledge of metabolic intervention possibilities.en
dc.publisherInforma Healthcare, London
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/172049/RS//
dc.rightsrestrictedAccess
dc.sourceInternational Journal of Food Sciences and Nutrition
dc.subjectBrainen
dc.subjectfatty acid compositionen
dc.subjectLactobacillus rhamnosus LA68en
dc.subjectC57BL/6en
dc.subjectliveren
dc.titleBrain and liver fatty acid composition changes upon consumption of Lactobacillus rhamnosus LA68en
dc.typearticle
dc.rights.licenseARR
dcterms.abstractШобајић, Слађана; Ивановић, Невена; Ђуричић, Ивана; Минић, Рајна; Ђорђевић, Брижита; Живковић, Ирена; Димитријевић, Љиљана;
dc.citation.volume66
dc.citation.issue1
dc.citation.spage93
dc.citation.epage97
dc.citation.other66(1): 93-97
dc.citation.rankM22
dc.identifier.wos000349223200009
dc.identifier.doi10.3109/09637486.2014.979313
dc.identifier.pmid25431181
dc.identifier.scopus2-s2.0-84922711210
dc.type.versionpublishedVersion


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Приказ основних података о документу