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dc.creatorMarinković, Valentina
dc.creatorAgbaba, Danica
dc.creatorKarljiković-Rajić, Katarina
dc.creatorComor, J
dc.creatorŽivanov-Stakić, Dobrila
dc.date.accessioned2019-09-02T10:51:59Z
dc.date.available2019-09-02T10:51:59Z
dc.date.issued2000
dc.identifier.issn0014-827X
dc.identifier.urihttp://farfar.pharmacy.bg.ac.rs/handle/123456789/239
dc.description.abstractThe photodecomposition of nisoldipine ((+/-)3-isobutyl-5-methyl-1,4-dihydro-2,6-dimethyl-4-(2-nitrophenyl)-pyridine-3,5-dicarboxylate), whereby its 4-(2-nitrosophenyl) pyridine analogue is obtained as the photolytic product, was investigated under daylight exposure by means of UV derivative spectrophotometry. The optimal instrumental parameters (120 nm/min scan speed: 2 nm slit width; Delta lambda = 10 nm and 5 s response time) for analogue derivative spectra were established for amplitudes D-1(285) and D-2(291) (measured to the baseline) of the nitroso analogue assay, as well as for D-1(386) of the parent compound-nisoldipine assay. Using the first-order derivative spectrum, the minimum detectable amount of nitroso analogue in the presence of nisoldipine was equivalent to an impurity level of 5% and by the second-order derivative spectrum, the determination limit was equivalent to an impurity level of 2%. The degradation of nisoldipine followed within 30 days and the calculated maximal degradation rate was 1.6% per day for nisoldipine raw material, but significantly lower values of 0.19 and 0.15% per day were obtained for Nisoldin(R) tablets (10 and 5 mg, respectively).en
dc.publisherElsevier Science Sa, Lausanne
dc.rightsrestrictedAccess
dc.sourceFarmaco
dc.titleUV derivative spectrophotometric study of the photochemical degradation of nisoldipineen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractЦомор, Ј; Маринковић, Валентина; Aгбаба, Даница; Карљиковић-Рајић, Катарина; Живанов-Стакић, Добрила;
dc.citation.volume55
dc.citation.issue2
dc.citation.spage128
dc.citation.epage133
dc.citation.other55(2): 128-133
dc.citation.rankM23
dc.identifier.wos000086306600009
dc.identifier.doi10.1016/S0014-827X(00)00004-5
dc.identifier.pmid10782384
dc.identifier.scopus2-s2.0-0034063177
dc.identifier.rcubconv_1241
dc.type.versionpublishedVersion


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