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dc.creatorKrstić, Marko
dc.creatorPopović, Miljana
dc.creatorDobričić, Vladimir
dc.creatorIbrić, Svetlana
dc.date.accessioned2019-09-02T11:47:06Z
dc.date.available2019-09-02T11:47:06Z
dc.date.issued2015
dc.identifier.issn1420-3049
dc.identifier.urihttp://farfar.pharmacy.bg.ac.rs/handle/123456789/2405
dc.description.abstractThe majority of drugs have a low dissolution rate, which is a limiting step for their absorption. In this manuscript, solid dispersions (SD), solid self-microemulsifying drug delivery systems (S-SMEDDS) and solid self-nanoemulsifying drug delivery systems (S-SNEDDS) were evaluated as potential formulation strategies to increase the dissolution rate of carbamazepine. Influence of increased dissolution rate on permeability of carbamazepine was evaluated using PAMPA test. In S-SMEDDS and S-SNEDDS formulations, the ratio of liquid SMEDDS/SNEDDS and solid carrier (Neusilin((R)) UFL2) was varied, and carbamazepine content was constant. In SD formulations, the ratio of carbamazepine and Neusilin((R)) UFL2, was varied. Formulations that showed the best dissolution rate of carbamazepine (SD_1:6, SMEDDS_1:1, SNEDDS_1:6) were mutually compared, characterization of these formulations was performed by DSC, PXRD and FT-IR analyses, and a PAMPA test was done. All formulations have shown a significant increase in dissolution rate compared to pure carbamazepine and immediate-release carbamazepine tablets. Formulation S-SMEDDS_1:1 showed the fastest release rate and permeability of carbamazepine. DSC, PXRD and FT-IR analyses confirmed that in S-SMEDDS and S-SNEDDS carbamazepine remained in polymorph form III, and that it was converted to an amorphous state in SD formulations. All formulations showed increased permeability of carbamazepine, compared to pure carbamazepine.en
dc.publisherMDPI, Basel
dc.relationinfo:eu-repo/grantAgreement/MESTD/Technological Development (TD or TR)/34007/RS//
dc.rightsopenAccess
dc.sourceMolecules
dc.subjectcarbamazepineen
dc.subjectdissolution rateen
dc.subjectPAMPA testen
dc.subjectsolid dispersionsen
dc.subjectS-SMEDDSen
dc.subjectS-SNEDDSen
dc.subjectcharacterizationen
dc.titleInfluence of Solid Drug Delivery System Formulation on Poorly Water-Soluble Drug Dissolution and Permeabilityen
dc.typearticle
dc.rights.licenseBY
dcterms.abstractКрстић, Марко; Ибрић, Светлана; Поповић, Миљана; Добричић, Владимир;
dc.citation.volume20
dc.citation.issue8
dc.citation.spage14684
dc.citation.epage14698
dc.citation.other20(8): 14684-14698
dc.citation.rankM22
dc.identifier.wos000361375400071
dc.identifier.doi10.3390/molecules200814684
dc.identifier.pmid26287134
dc.identifier.scopus2-s2.0-84941249098
dc.identifier.fulltexthttp://farfar.pharmacy.bg.ac.rs//bitstream/id/1097/2403.pdf
dc.identifier.rcubconv_3393
dc.type.versionpublishedVersion


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