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Application of experimental design in the examination of the dissolution rate of carbamazepine from formulations. Characterization of the optimal formulation by DSC, TGA, FT-IR and PXRD analysis

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2015
2404.pdf (262.3Kb)
Authors
Krstić, Marko
Ražić, Slavica
Vasiljević, Dragana
Spasojević, Durdija
Ibrić, Svetlana
Article (Published version)
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Abstract
Poor solubility is one of the key reasons for the poor bioavailability of carbamazepine drugs. This study considers formulation of solid surfactant systems with carbamazepine, in order to increase its dissolution rate. Solid-state surfactant systems were formed by application of fractional experimental design. Poloxamer 237 and Poloxamer 338 were used as the surfactants and Brij (R) 35 was used as the co-surfactant. The ratios of the excipients and carbamazepine were varied and their effects on the dissolution rate of carbamazepine were examined. Moreover, the effects of the addition of natural (diatomite) and a synthetic adsorbent carrier (Neusilin (R) UFL2) on the dissolution rate of carbamazepine were also tested. The prepared surfactant systems were characterized and the influences of the excipients on possible changes of the polymorphous form of carbamazepine examined by application of analytical techniques (DSC, TGA, FT-IR and PXRD). It was determined that an appropriate selectio...n of the excipient type and ratio could provide a significant increase in the carbamazepine dissolution rate. By application of analytical techniques, it was found that the employed excipients induce a transition of carbamazepine into the amorphous form and that the selected sample was stable for three months, when kept under ambient conditions.

Keywords:
poloxamer / neusilin / diatomite / solid surfactant drug delivery systems / polymorphous transition
Source:
Journal of the Serbian Chemical Society, 2015, 80, 2, 209-222
Publisher:
  • Srpsko hemijsko društvo, Beograd
Projects:
  • Advanced technologies for controlled release from solid drug delivery systems (RS-34007)

DOI: 10.2298/JSC030814114K

ISSN: 0352-5139

WoS: 000351326300009

Scopus: 2-s2.0-84914671083
[ Google Scholar ]
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URI
http://farfar.pharmacy.bg.ac.rs/handle/123456789/2406
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  • Radovi istraživača / Researchers’ publications
Institution
Pharmacy

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