Приказ основних података о документу

dc.creatorVučićević, Katarina
dc.creatorJovanović, Marija
dc.creatorGolubović, Bojana
dc.creatorVezmar-Kovačević, Sandra
dc.creatorMiljković, Branislava
dc.creatorMartinović, Žarko J.
dc.creatorProstran, Milica
dc.date.accessioned2019-09-02T11:47:13Z
dc.date.available2019-09-02T11:47:13Z
dc.date.issued2015
dc.identifier.issn0031-6970
dc.identifier.urihttps://farfar.pharmacy.bg.ac.rs/handle/123456789/2408
dc.description.abstractThe present study aimed to establish population pharmacokinetic model for phenobarbital (PB), examining and quantifying the magnitude of PB interactions with other antiepileptic drugs concomitantly used and to demonstrate its use for individualization of PB dosing regimen in adult epileptic patients. In total 205 PB concentrations were obtained during routine clinical monitoring of 136 adult epilepsy patients. PB steady state concentrations were measured by homogeneous enzyme immunoassay. Nonlinear mixed effects modelling (NONMEM) was applied for data analyses and evaluation of the final model. According to the final population model, significant determinant of apparent PB clearance (CL/F) was daily dose of concomitantly given valproic acid (VPA). Typical value of PB CL/F for final model was estimated at 0.314 l/h. Based on the final model, co-therapy with usual VPA dose of 1000 mg/day, resulted in PB CL/F average decrease of about 25 %, while 2000 mg/day leads to an average 50 % decrease in PB CL/F. Developed population PB model may be used in estimating individual CL/F for adult epileptic patients and could be applied for individualizing dosing regimen taking into account dose-dependent effect of concomitantly given VPA.en
dc.publisherSpringer Heidelberg, Heidelberg
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/175023/RS//
dc.rightsrestrictedAccess
dc.sourceEuropean Journal of Clinical Pharmacology
dc.subjectPhenobarbitalen
dc.subjectInteractionsen
dc.subjectPharmacokineticsen
dc.subjectTherapeutic drug monitoringen
dc.subjectNONMEMen
dc.titleNonlinear mixed effects modelling approach in investigating phenobarbital pharmacokinetic interactions in epileptic patientsen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractГолубовић, Бојана; Простран, Милица; Миљковић, Бранислава; Вучићевић, Катарина; Везмар-Ковачевић, Сандра; Јовановић, Марија; Мартиновић, Жарко Ј.;
dc.citation.volume71
dc.citation.issue2
dc.citation.spage183
dc.citation.epage190
dc.citation.other71(2): 183-190
dc.citation.rankM22
dc.identifier.wos000348148200007
dc.identifier.doi10.1007/s00228-014-1778-7
dc.identifier.pmid25380628
dc.identifier.scopus2-s2.0-84922074826
dc.type.versionpublishedVersion


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Приказ основних података о документу