The influence of certain molecular descriptors of fecal elimination of angiotensin II receptor antagonists

2015
Authors
Trbojević-Stanković, JasnaOdović, Jadranka

Jelić, Ratomir

Nešić, Dejan M.
Stojimirović, Biljana
Article (Published version)
Metadata
Show full item recordAbstract
Angiotensin II receptor antagonists (ARBs) modulate the function of the renin-angiotensin-aldosterone system and are commonly prescribed antihypertensive drugs, especially in patients with renal failure. In this study, the relationship between several molecular properties of seven ARBs (candesartan, eprosartan, irbesartan, losartan, olmesartan, telmisartan, valsartan) and their fecal elimination data obtained from the literature were investigated. The ARB molecular descriptors were calculated using three software packages. Simple linear regression analysis showed the best correlation between fecal elimination data and lipophilicity descriptor, ClogP values (R-2 = 0.725). Multiple linear regression was applied to examine the correlation of ARBs' fecal elimination data with their lipophilicity and one additional, calculated descriptor. The best correlation (R-2 = 0.909 with an acceptable probability value, P lt 0.05) was established between the ARB fecal elimination data and their lipo...philicity and aqueous solubility data. Applying computed molecular descriptors for evaluating drug elimination is of great importance in drug research.
Keywords:
angiotensin II receptor antagonists / lipophilicity / aqueous solubility / fecal eliminationSource:
Archives of Biological Sciences, 2015, 67, 1, 103-109Publisher:
- Srpsko biološko društvo, Beograd, i dr.
DOI: 10.2298/ABS141104011T
ISSN: 0354-4664
WoS: 000352003500011
Scopus: 2-s2.0-84937440347
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PharmacyTY - JOUR AU - Trbojević-Stanković, Jasna AU - Odović, Jadranka AU - Jelić, Ratomir AU - Nešić, Dejan M. AU - Stojimirović, Biljana PY - 2015 UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2420 AB - Angiotensin II receptor antagonists (ARBs) modulate the function of the renin-angiotensin-aldosterone system and are commonly prescribed antihypertensive drugs, especially in patients with renal failure. In this study, the relationship between several molecular properties of seven ARBs (candesartan, eprosartan, irbesartan, losartan, olmesartan, telmisartan, valsartan) and their fecal elimination data obtained from the literature were investigated. The ARB molecular descriptors were calculated using three software packages. Simple linear regression analysis showed the best correlation between fecal elimination data and lipophilicity descriptor, ClogP values (R-2 = 0.725). Multiple linear regression was applied to examine the correlation of ARBs' fecal elimination data with their lipophilicity and one additional, calculated descriptor. The best correlation (R-2 = 0.909 with an acceptable probability value, P lt 0.05) was established between the ARB fecal elimination data and their lipophilicity and aqueous solubility data. Applying computed molecular descriptors for evaluating drug elimination is of great importance in drug research. PB - Srpsko biološko društvo, Beograd, i dr. T2 - Archives of Biological Sciences T1 - The influence of certain molecular descriptors of fecal elimination of angiotensin II receptor antagonists VL - 67 IS - 1 SP - 103 EP - 109 DO - 10.2298/ABS141104011T ER -
@article{ author = "Trbojević-Stanković, Jasna and Odović, Jadranka and Jelić, Ratomir and Nešić, Dejan M. and Stojimirović, Biljana", year = "2015", abstract = "Angiotensin II receptor antagonists (ARBs) modulate the function of the renin-angiotensin-aldosterone system and are commonly prescribed antihypertensive drugs, especially in patients with renal failure. In this study, the relationship between several molecular properties of seven ARBs (candesartan, eprosartan, irbesartan, losartan, olmesartan, telmisartan, valsartan) and their fecal elimination data obtained from the literature were investigated. The ARB molecular descriptors were calculated using three software packages. Simple linear regression analysis showed the best correlation between fecal elimination data and lipophilicity descriptor, ClogP values (R-2 = 0.725). Multiple linear regression was applied to examine the correlation of ARBs' fecal elimination data with their lipophilicity and one additional, calculated descriptor. The best correlation (R-2 = 0.909 with an acceptable probability value, P lt 0.05) was established between the ARB fecal elimination data and their lipophilicity and aqueous solubility data. Applying computed molecular descriptors for evaluating drug elimination is of great importance in drug research.", publisher = "Srpsko biološko društvo, Beograd, i dr.", journal = "Archives of Biological Sciences", title = "The influence of certain molecular descriptors of fecal elimination of angiotensin II receptor antagonists", volume = "67", number = "1", pages = "103-109", doi = "10.2298/ABS141104011T" }
Trbojević-Stanković, J., Odović, J., Jelić, R., Nešić, D. M.,& Stojimirović, B.. (2015). The influence of certain molecular descriptors of fecal elimination of angiotensin II receptor antagonists. in Archives of Biological Sciences Srpsko biološko društvo, Beograd, i dr.., 67(1), 103-109. https://doi.org/10.2298/ABS141104011T
Trbojević-Stanković J, Odović J, Jelić R, Nešić DM, Stojimirović B. The influence of certain molecular descriptors of fecal elimination of angiotensin II receptor antagonists. in Archives of Biological Sciences. 2015;67(1):103-109. doi:10.2298/ABS141104011T .
Trbojević-Stanković, Jasna, Odović, Jadranka, Jelić, Ratomir, Nešić, Dejan M., Stojimirović, Biljana, "The influence of certain molecular descriptors of fecal elimination of angiotensin II receptor antagonists" in Archives of Biological Sciences, 67, no. 1 (2015):103-109, https://doi.org/10.2298/ABS141104011T . .