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dc.creatorĐekić, Ljiljana
dc.creatorMartinović, Martina
dc.creatorStepanović-Petrović, Radica
dc.creatorTomić, Maja
dc.creatorMicov, Ana
dc.creatorPrimorac, Marija
dc.date.accessioned2019-09-02T11:47:39Z
dc.date.available2019-09-02T11:47:39Z
dc.date.issued2015
dc.identifier.issn0022-3549
dc.identifier.urihttp://farfar.pharmacy.bg.ac.rs/handle/123456789/2426
dc.description.abstractNonionic surfactants (caprylocaproyl macrogol-8 glycerides, octoxynol-12, polysorbate-20, and polyethylene glycol-40 hydrogenated castor oil) (47.03%, w/w), costabilizer (poloxamer 407) (12%-20%, w/w), oil (isopropyl myristate) (5.22%, w/w), water (q.s. ad 100%, w/w), and ibuprofen (5%, w/w) were used to develop oil-in-water microemulsions with Newtonian flow behavior, low viscosity (from 368 +/- 38 to 916 +/- 46 mPa s), and average droplet size from 14.79 +/- 0.31 to 16.54 +/- 0.75 nm. Ibuprofen in vitro release from the microemulsions was in accordance with zero-order kinetics (R-0(2) > 0.99) for at least 12 h. The maximum drug release rate (3.55%h(-1)) was from the microemulsion M3 comprising 16%, w/w of poloxamer 407. The release rate of ibuprofen from the reference hydrogel followed Higuchi kinetics (R-H(2) > 0.99), and drug amount released after the 6th hour was negligible. In a rat model of inflammation, the microemulsion M3 was significantly more efficacious than the reference hydrogel in exerting antihyperalgesic effects in prophylactic topical treatment, whereas they were comparable in therapeutic treatment as well as in producing antiedematous effect in both protocols. No obvious skin irritation was observed in in vivo studies. The developed nonionic surfactants-based microemulsions containing the optimal concentration of poloxamer 407 could be promising carriers for sustained regional delivery of ibuprofen via topical administration.en
dc.publisherWiley, Hoboken
dc.relationinfo:eu-repo/grantAgreement/MESTD/Technological Development (TD or TR)/34007/RS//
dc.rightsrestrictedAccess
dc.sourceJournal of Pharmaceutical Sciences
dc.subjectbiocompatibilityen
dc.subjectcontrolled releaseen
dc.subjectdrug delivery systemsen
dc.subjectlight scattering (dynamic)en
dc.subjectmicroemulsionen
dc.subjectnanotechnologyen
dc.subjectphysicochemical propertiesen
dc.subjectpolymersen
dc.subjectskinen
dc.titleDesign of Block Copolymer Costabilized Nonionic Microemulsions and Their In Vitro and In Vivo Assessment as Carriers for Sustained Regional Delivery of Ibuprofen via Topical Administrationen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractЂекић, Љиљана; Степановић-Петровић, Радица; Мицов, Aна; Мартиновић, Мартина; Приморац, Марија; Томић, Маја;
dc.citation.volume104
dc.citation.issue8
dc.citation.spage2501
dc.citation.epage2512
dc.citation.other104(8): 2501-2512
dc.citation.rankM22
dc.identifier.wos000358009700012
dc.identifier.doi10.1002/jps.24494
dc.identifier.pmid26045240
dc.identifier.scopus2-s2.0-84947047528
dc.identifier.rcubconv_3342
dc.type.versionpublishedVersion


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