45S5Bioglass (R)-based scaffolds coated with selenium nanoparticles or with poly(lactide-co-glycolide)/selenium particles: Processing, evaluation and antibacterial activity
2015
Authors
Stevanović, MagdalenaFilipović, Nenad
Đurđević, Jelena
Lukić, Miodrag
Milenković, Marina
Boccaccini, Aldo
Article (Published version)
Metadata
Show full item recordAbstract
In the bone tissue engineering field, there is a growing interest in the application of bioactive glass scaffolds (45S5Bioglass (R)) due to their bone bonding ability, osteoconductivity and osteoinductivity. However, such scaffolds still lack some of the required functionalities to enable the successful formation of new bone, e.g. effective antibacterial properties. A large number of studies suggest that selenium (Se) has significant role in antioxidant protection, enhanced immune surveillance and modulation of cell proliferation. Selenium nanoparticles (SeNp) have also been reported to possess antibacterial as well as antiviral activities. In this investigation, uniform, stable, amorphous SeNp have been synthesized and additionally immobilized within spherical PLGA particles (PLGA/SeNp). These particles were used to coat bioactive glass-based scaffolds synthesized by the foam replica method. Samples were characterized by X-ray diffraction (XRD), Fourier transform infrared spectroscopy... (FTIR), scanning electron microscopy. (SEM), energy dispersive X-ray spectroscopy (EDS) and transmission electron microscopy (TEM). SeNp, 45S5Bioglass (R)/SeNp and 45S5Bioglass (R)/PLGA/SeNp showed a considerable antibacterial activity against Gram positive bacteria, Staphylococcus aureus and Staphylococcus epidermidis, one of the main causative agents of orthopedic infections. The functionalized Se-coated bioactive glass scaffolds represent a new family of bioactive, antibacterial scaffolds for bone tissue engineering applications.
Keywords:
Scaffold / Bioglass / Selenium nanoparticles / PLGA / Antibacterial activitySource:
Colloids and Surfaces B: Biointerfaces, 2015, 132, 208-215Publisher:
- Elsevier Science BV, Amsterdam
Funding / projects:
- German Academic Exchange Service (DAAD)
DOI: 10.1016/j.colsurfb.2015.05.024
ISSN: 0927-7765
PubMed: 26047884
WoS: 000358094000026
Scopus: 2-s2.0-84936073662
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PharmacyTY - JOUR AU - Stevanović, Magdalena AU - Filipović, Nenad AU - Đurđević, Jelena AU - Lukić, Miodrag AU - Milenković, Marina AU - Boccaccini, Aldo PY - 2015 UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2427 AB - In the bone tissue engineering field, there is a growing interest in the application of bioactive glass scaffolds (45S5Bioglass (R)) due to their bone bonding ability, osteoconductivity and osteoinductivity. However, such scaffolds still lack some of the required functionalities to enable the successful formation of new bone, e.g. effective antibacterial properties. A large number of studies suggest that selenium (Se) has significant role in antioxidant protection, enhanced immune surveillance and modulation of cell proliferation. Selenium nanoparticles (SeNp) have also been reported to possess antibacterial as well as antiviral activities. In this investigation, uniform, stable, amorphous SeNp have been synthesized and additionally immobilized within spherical PLGA particles (PLGA/SeNp). These particles were used to coat bioactive glass-based scaffolds synthesized by the foam replica method. Samples were characterized by X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FTIR), scanning electron microscopy. (SEM), energy dispersive X-ray spectroscopy (EDS) and transmission electron microscopy (TEM). SeNp, 45S5Bioglass (R)/SeNp and 45S5Bioglass (R)/PLGA/SeNp showed a considerable antibacterial activity against Gram positive bacteria, Staphylococcus aureus and Staphylococcus epidermidis, one of the main causative agents of orthopedic infections. The functionalized Se-coated bioactive glass scaffolds represent a new family of bioactive, antibacterial scaffolds for bone tissue engineering applications. PB - Elsevier Science BV, Amsterdam T2 - Colloids and Surfaces B: Biointerfaces T1 - 45S5Bioglass (R)-based scaffolds coated with selenium nanoparticles or with poly(lactide-co-glycolide)/selenium particles: Processing, evaluation and antibacterial activity VL - 132 SP - 208 EP - 215 DO - 10.1016/j.colsurfb.2015.05.024 ER -
@article{ author = "Stevanović, Magdalena and Filipović, Nenad and Đurđević, Jelena and Lukić, Miodrag and Milenković, Marina and Boccaccini, Aldo", year = "2015", abstract = "In the bone tissue engineering field, there is a growing interest in the application of bioactive glass scaffolds (45S5Bioglass (R)) due to their bone bonding ability, osteoconductivity and osteoinductivity. However, such scaffolds still lack some of the required functionalities to enable the successful formation of new bone, e.g. effective antibacterial properties. A large number of studies suggest that selenium (Se) has significant role in antioxidant protection, enhanced immune surveillance and modulation of cell proliferation. Selenium nanoparticles (SeNp) have also been reported to possess antibacterial as well as antiviral activities. In this investigation, uniform, stable, amorphous SeNp have been synthesized and additionally immobilized within spherical PLGA particles (PLGA/SeNp). These particles were used to coat bioactive glass-based scaffolds synthesized by the foam replica method. Samples were characterized by X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FTIR), scanning electron microscopy. (SEM), energy dispersive X-ray spectroscopy (EDS) and transmission electron microscopy (TEM). SeNp, 45S5Bioglass (R)/SeNp and 45S5Bioglass (R)/PLGA/SeNp showed a considerable antibacterial activity against Gram positive bacteria, Staphylococcus aureus and Staphylococcus epidermidis, one of the main causative agents of orthopedic infections. The functionalized Se-coated bioactive glass scaffolds represent a new family of bioactive, antibacterial scaffolds for bone tissue engineering applications.", publisher = "Elsevier Science BV, Amsterdam", journal = "Colloids and Surfaces B: Biointerfaces", title = "45S5Bioglass (R)-based scaffolds coated with selenium nanoparticles or with poly(lactide-co-glycolide)/selenium particles: Processing, evaluation and antibacterial activity", volume = "132", pages = "208-215", doi = "10.1016/j.colsurfb.2015.05.024" }
Stevanović, M., Filipović, N., Đurđević, J., Lukić, M., Milenković, M.,& Boccaccini, A.. (2015). 45S5Bioglass (R)-based scaffolds coated with selenium nanoparticles or with poly(lactide-co-glycolide)/selenium particles: Processing, evaluation and antibacterial activity. in Colloids and Surfaces B: Biointerfaces Elsevier Science BV, Amsterdam., 132, 208-215. https://doi.org/10.1016/j.colsurfb.2015.05.024
Stevanović M, Filipović N, Đurđević J, Lukić M, Milenković M, Boccaccini A. 45S5Bioglass (R)-based scaffolds coated with selenium nanoparticles or with poly(lactide-co-glycolide)/selenium particles: Processing, evaluation and antibacterial activity. in Colloids and Surfaces B: Biointerfaces. 2015;132:208-215. doi:10.1016/j.colsurfb.2015.05.024 .
Stevanović, Magdalena, Filipović, Nenad, Đurđević, Jelena, Lukić, Miodrag, Milenković, Marina, Boccaccini, Aldo, "45S5Bioglass (R)-based scaffolds coated with selenium nanoparticles or with poly(lactide-co-glycolide)/selenium particles: Processing, evaluation and antibacterial activity" in Colloids and Surfaces B: Biointerfaces, 132 (2015):208-215, https://doi.org/10.1016/j.colsurfb.2015.05.024 . .