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dc.creatorStevanović, Magdalena
dc.creatorFilipović, Nenad
dc.creatorĐurđević, Jelena
dc.creatorLukić, Miodrag
dc.creatorMilenković, Marina
dc.creatorBoccaccini, Aldo
dc.date.accessioned2019-09-02T11:47:41Z
dc.date.available2019-09-02T11:47:41Z
dc.date.issued2015
dc.identifier.issn0927-7765
dc.identifier.urihttps://farfar.pharmacy.bg.ac.rs/handle/123456789/2427
dc.description.abstractIn the bone tissue engineering field, there is a growing interest in the application of bioactive glass scaffolds (45S5Bioglass (R)) due to their bone bonding ability, osteoconductivity and osteoinductivity. However, such scaffolds still lack some of the required functionalities to enable the successful formation of new bone, e.g. effective antibacterial properties. A large number of studies suggest that selenium (Se) has significant role in antioxidant protection, enhanced immune surveillance and modulation of cell proliferation. Selenium nanoparticles (SeNp) have also been reported to possess antibacterial as well as antiviral activities. In this investigation, uniform, stable, amorphous SeNp have been synthesized and additionally immobilized within spherical PLGA particles (PLGA/SeNp). These particles were used to coat bioactive glass-based scaffolds synthesized by the foam replica method. Samples were characterized by X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FTIR), scanning electron microscopy. (SEM), energy dispersive X-ray spectroscopy (EDS) and transmission electron microscopy (TEM). SeNp, 45S5Bioglass (R)/SeNp and 45S5Bioglass (R)/PLGA/SeNp showed a considerable antibacterial activity against Gram positive bacteria, Staphylococcus aureus and Staphylococcus epidermidis, one of the main causative agents of orthopedic infections. The functionalized Se-coated bioactive glass scaffolds represent a new family of bioactive, antibacterial scaffolds for bone tissue engineering applications.en
dc.publisherElsevier Science BV, Amsterdam
dc.relationGerman Academic Exchange Service (DAAD)
dc.rightsopenAccess
dc.sourceColloids and Surfaces B: Biointerfaces
dc.subjectScaffolden
dc.subjectBioglassen
dc.subjectSelenium nanoparticlesen
dc.subjectPLGAen
dc.subjectAntibacterial activityen
dc.title45S5Bioglass (R)-based scaffolds coated with selenium nanoparticles or with poly(lactide-co-glycolide)/selenium particles: Processing, evaluation and antibacterial activityen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractСтевановић, Магдалена; Ђурђевић, Јелена; Боццаццини, Aлдо; Лукић, Миодраг; Филиповић, Ненад; Миленковић, Марина;
dc.citation.volume132
dc.citation.spage208
dc.citation.epage215
dc.citation.other132: 208-215
dc.citation.rankM21
dc.identifier.wos000358094000026
dc.identifier.doi10.1016/j.colsurfb.2015.05.024
dc.identifier.pmid26047884
dc.identifier.scopus2-s2.0-84936073662
dc.identifier.fulltexthttps://farfar.pharmacy.bg.ac.rs//bitstream/id/1117/2425.pdf
dc.identifier.rcubconv_3343
dc.type.versionpublishedVersion


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