Cohesion and the aneuploid phenotype in Alzheimer's disease: A tale of genome instability
Само за регистроване кориснике
2015
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
Neurons are postmitotic cells that are in permanent cell cycle arrest. However, components of the cell cycle machinery that are expressed in Alzheimer's disease (AD) neurons are showing features of a cycling cell and those attributed to a postmitotic cell as well. Furthermore, the unique physiological operations taking place in neurons, ascribed to "core cell cycle regulators" are also key regulators in cell division. Functions of these cell cycle regulators include neuronal migration, axonal elongation, axon pruning, dendrite morphogenesis and synaptic maturation and plasticity. In this review, we focus on cohesion and cohesion related proteins in reference to their neuronal functions and how impaired centromere/cohesion dynamics may connect cell cycle dysfunction to aneuploidy in AD.
Кључне речи:
Alzheimer's disease (AD) / Aneuploidy / Genomic mosaicism / Cell cycle / CohesionИзвор:
Neuroscience and Biobehavioral Reviews, 2015, 55, 365-374Издавач:
- Pergamon-Elsevier Science Ltd, Oxford
Финансирање / пројекти:
DOI: 10.1016/j.neubiorev.2015.05.010
ISSN: 0149-7634
PubMed: 26003528
WoS: 000358271000025
Scopus: 2-s2.0-84930622205
Институција/група
PharmacyTY - JOUR AU - Bajić, Vladan AU - Potparević, Biljana AU - Živković, Lada AU - Isenović, Esma AU - Arendt, Thomas PY - 2015 UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2430 AB - Neurons are postmitotic cells that are in permanent cell cycle arrest. However, components of the cell cycle machinery that are expressed in Alzheimer's disease (AD) neurons are showing features of a cycling cell and those attributed to a postmitotic cell as well. Furthermore, the unique physiological operations taking place in neurons, ascribed to "core cell cycle regulators" are also key regulators in cell division. Functions of these cell cycle regulators include neuronal migration, axonal elongation, axon pruning, dendrite morphogenesis and synaptic maturation and plasticity. In this review, we focus on cohesion and cohesion related proteins in reference to their neuronal functions and how impaired centromere/cohesion dynamics may connect cell cycle dysfunction to aneuploidy in AD. PB - Pergamon-Elsevier Science Ltd, Oxford T2 - Neuroscience and Biobehavioral Reviews T1 - Cohesion and the aneuploid phenotype in Alzheimer's disease: A tale of genome instability VL - 55 SP - 365 EP - 374 DO - 10.1016/j.neubiorev.2015.05.010 ER -
@article{ author = "Bajić, Vladan and Potparević, Biljana and Živković, Lada and Isenović, Esma and Arendt, Thomas", year = "2015", abstract = "Neurons are postmitotic cells that are in permanent cell cycle arrest. However, components of the cell cycle machinery that are expressed in Alzheimer's disease (AD) neurons are showing features of a cycling cell and those attributed to a postmitotic cell as well. Furthermore, the unique physiological operations taking place in neurons, ascribed to "core cell cycle regulators" are also key regulators in cell division. Functions of these cell cycle regulators include neuronal migration, axonal elongation, axon pruning, dendrite morphogenesis and synaptic maturation and plasticity. In this review, we focus on cohesion and cohesion related proteins in reference to their neuronal functions and how impaired centromere/cohesion dynamics may connect cell cycle dysfunction to aneuploidy in AD.", publisher = "Pergamon-Elsevier Science Ltd, Oxford", journal = "Neuroscience and Biobehavioral Reviews", title = "Cohesion and the aneuploid phenotype in Alzheimer's disease: A tale of genome instability", volume = "55", pages = "365-374", doi = "10.1016/j.neubiorev.2015.05.010" }
Bajić, V., Potparević, B., Živković, L., Isenović, E.,& Arendt, T.. (2015). Cohesion and the aneuploid phenotype in Alzheimer's disease: A tale of genome instability. in Neuroscience and Biobehavioral Reviews Pergamon-Elsevier Science Ltd, Oxford., 55, 365-374. https://doi.org/10.1016/j.neubiorev.2015.05.010
Bajić V, Potparević B, Živković L, Isenović E, Arendt T. Cohesion and the aneuploid phenotype in Alzheimer's disease: A tale of genome instability. in Neuroscience and Biobehavioral Reviews. 2015;55:365-374. doi:10.1016/j.neubiorev.2015.05.010 .
Bajić, Vladan, Potparević, Biljana, Živković, Lada, Isenović, Esma, Arendt, Thomas, "Cohesion and the aneuploid phenotype in Alzheimer's disease: A tale of genome instability" in Neuroscience and Biobehavioral Reviews, 55 (2015):365-374, https://doi.org/10.1016/j.neubiorev.2015.05.010 . .