Effect of nutritionally relevant doses of long-chain N-3 pufa on lipid status, oxidative stress and inflammatory markers in an average middle-aged serbian population
2015
Authors
Đuričić, IvanaKotur-Stevuljević, Jelena
Miljković, Milica
Kerkez, Mirko
Đorđević, Vladimir
Đurasić, Ljubomir
Šobajić, Slađana
Article (Published version)
Metadata
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Background: This study investigated the effects of a nutritionally relevant intake of eicosapentaenoic (EPA) and docosahexaenoic (DHA) fatty acids derived from oily fish or a fish oil supplement on selected cardiovascular risk factors in average middle-aged individuals. Methods: Thirty-three participants were randomized to receive salmon (oily fish) providing 274 mg EPA + 671 mg DHA/day or a commercial fish oil supplement providing 396 mg EPA + 250 mg DHA/day in a cross-over trial over an 8-week period separated by a 6-month washout period. Blood samples were collected before and after each intervention and lipids, inflammatory and oxidative stress parameters were determined. Results: Plasma levels of EPA, DHA and total n-3 fatty acids significantly increased after both interventions. A decreasing trend in triglycerides was more pronounced with salmon than with the fish oil supplement, but the changes noticed were not significant. Although there were no relevant changes in inflammatory... marker concentrations at the end of both interventions, significant negative correlations were noticed between total plasma n-3 fatty acids and soluble intercellular adhesion molecule and C-reactive protein throughout the whole intervention period (p lt 0.05). Among the oxidative stress parameters, intervention with salmon showed a prooxidative effect through a superoxide anion increase (p = 0.025). A relevant positive correlation was also found between its concentration and total plasma n-3 fatty acids (p lt 0.05). Other oxidative stress markers were not significantly influenced by the dietary interventions applied. Conclusions: Following two sets of recommendations for n-3 fatty acids intake aimed at the general public had only a moderate effect on the selected cardiovascular risk factors in average healthy middle-aged subjects over a short-term period.
Keywords:
n-3 fatty acids / fish and fish oil supplements / circulating inflammatory markers / oxidative stress / cardiovascular diseaseSource:
Journal of Medical Biochemistry, 2015, 34, 3, 304-313Publisher:
- Društvo medicinskih biohemičara Srbije, Beograd i Versita
Funding / projects:
- Develooment and utilization of novel and traditional technologies in production of competitive food products with added valued for national and global market - CREATING WEALTH FROM THE WEALTH OF SERBIA (RS-46001)
- Pharmanova d.o.o., Belgrade, Serbia
DOI: 10.2478/jomb-2014-0039
ISSN: 1452-8258
PubMed: 28356841
WoS: 000358329200005
Scopus: 2-s2.0-84938311583
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Institution/Community
PharmacyTY - JOUR AU - Đuričić, Ivana AU - Kotur-Stevuljević, Jelena AU - Miljković, Milica AU - Kerkez, Mirko AU - Đorđević, Vladimir AU - Đurasić, Ljubomir AU - Šobajić, Slađana PY - 2015 UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2431 AB - Background: This study investigated the effects of a nutritionally relevant intake of eicosapentaenoic (EPA) and docosahexaenoic (DHA) fatty acids derived from oily fish or a fish oil supplement on selected cardiovascular risk factors in average middle-aged individuals. Methods: Thirty-three participants were randomized to receive salmon (oily fish) providing 274 mg EPA + 671 mg DHA/day or a commercial fish oil supplement providing 396 mg EPA + 250 mg DHA/day in a cross-over trial over an 8-week period separated by a 6-month washout period. Blood samples were collected before and after each intervention and lipids, inflammatory and oxidative stress parameters were determined. Results: Plasma levels of EPA, DHA and total n-3 fatty acids significantly increased after both interventions. A decreasing trend in triglycerides was more pronounced with salmon than with the fish oil supplement, but the changes noticed were not significant. Although there were no relevant changes in inflammatory marker concentrations at the end of both interventions, significant negative correlations were noticed between total plasma n-3 fatty acids and soluble intercellular adhesion molecule and C-reactive protein throughout the whole intervention period (p lt 0.05). Among the oxidative stress parameters, intervention with salmon showed a prooxidative effect through a superoxide anion increase (p = 0.025). A relevant positive correlation was also found between its concentration and total plasma n-3 fatty acids (p lt 0.05). Other oxidative stress markers were not significantly influenced by the dietary interventions applied. Conclusions: Following two sets of recommendations for n-3 fatty acids intake aimed at the general public had only a moderate effect on the selected cardiovascular risk factors in average healthy middle-aged subjects over a short-term period. PB - Društvo medicinskih biohemičara Srbije, Beograd i Versita T2 - Journal of Medical Biochemistry T1 - Effect of nutritionally relevant doses of long-chain N-3 pufa on lipid status, oxidative stress and inflammatory markers in an average middle-aged serbian population VL - 34 IS - 3 SP - 304 EP - 313 DO - 10.2478/jomb-2014-0039 ER -
@article{ author = "Đuričić, Ivana and Kotur-Stevuljević, Jelena and Miljković, Milica and Kerkez, Mirko and Đorđević, Vladimir and Đurasić, Ljubomir and Šobajić, Slađana", year = "2015", abstract = "Background: This study investigated the effects of a nutritionally relevant intake of eicosapentaenoic (EPA) and docosahexaenoic (DHA) fatty acids derived from oily fish or a fish oil supplement on selected cardiovascular risk factors in average middle-aged individuals. Methods: Thirty-three participants were randomized to receive salmon (oily fish) providing 274 mg EPA + 671 mg DHA/day or a commercial fish oil supplement providing 396 mg EPA + 250 mg DHA/day in a cross-over trial over an 8-week period separated by a 6-month washout period. Blood samples were collected before and after each intervention and lipids, inflammatory and oxidative stress parameters were determined. Results: Plasma levels of EPA, DHA and total n-3 fatty acids significantly increased after both interventions. A decreasing trend in triglycerides was more pronounced with salmon than with the fish oil supplement, but the changes noticed were not significant. Although there were no relevant changes in inflammatory marker concentrations at the end of both interventions, significant negative correlations were noticed between total plasma n-3 fatty acids and soluble intercellular adhesion molecule and C-reactive protein throughout the whole intervention period (p lt 0.05). Among the oxidative stress parameters, intervention with salmon showed a prooxidative effect through a superoxide anion increase (p = 0.025). A relevant positive correlation was also found between its concentration and total plasma n-3 fatty acids (p lt 0.05). Other oxidative stress markers were not significantly influenced by the dietary interventions applied. Conclusions: Following two sets of recommendations for n-3 fatty acids intake aimed at the general public had only a moderate effect on the selected cardiovascular risk factors in average healthy middle-aged subjects over a short-term period.", publisher = "Društvo medicinskih biohemičara Srbije, Beograd i Versita", journal = "Journal of Medical Biochemistry", title = "Effect of nutritionally relevant doses of long-chain N-3 pufa on lipid status, oxidative stress and inflammatory markers in an average middle-aged serbian population", volume = "34", number = "3", pages = "304-313", doi = "10.2478/jomb-2014-0039" }
Đuričić, I., Kotur-Stevuljević, J., Miljković, M., Kerkez, M., Đorđević, V., Đurasić, L.,& Šobajić, S.. (2015). Effect of nutritionally relevant doses of long-chain N-3 pufa on lipid status, oxidative stress and inflammatory markers in an average middle-aged serbian population. in Journal of Medical Biochemistry Društvo medicinskih biohemičara Srbije, Beograd i Versita., 34(3), 304-313. https://doi.org/10.2478/jomb-2014-0039
Đuričić I, Kotur-Stevuljević J, Miljković M, Kerkez M, Đorđević V, Đurasić L, Šobajić S. Effect of nutritionally relevant doses of long-chain N-3 pufa on lipid status, oxidative stress and inflammatory markers in an average middle-aged serbian population. in Journal of Medical Biochemistry. 2015;34(3):304-313. doi:10.2478/jomb-2014-0039 .
Đuričić, Ivana, Kotur-Stevuljević, Jelena, Miljković, Milica, Kerkez, Mirko, Đorđević, Vladimir, Đurasić, Ljubomir, Šobajić, Slađana, "Effect of nutritionally relevant doses of long-chain N-3 pufa on lipid status, oxidative stress and inflammatory markers in an average middle-aged serbian population" in Journal of Medical Biochemistry, 34, no. 3 (2015):304-313, https://doi.org/10.2478/jomb-2014-0039 . .