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dc.creatorMirjanić-Azarić, Bosa
dc.creatorJelić-Ivanović, Zorana
dc.creatorZeljković, Aleksandra
dc.creatorVekić, Jelena
dc.creatorJuergens, Guenther
dc.creatorMilivojac, Tatjana
dc.creatorAvram, Sanja
dc.creatorCorić, Jozo
dc.creatorMarc, Janja
dc.creatorCerne, Darko
dc.date.accessioned2019-09-02T11:47:49Z
dc.date.available2019-09-02T11:47:49Z
dc.date.issued2015
dc.identifier.issn1452-8258
dc.identifier.urihttp://farfar.pharmacy.bg.ac.rs/handle/123456789/2432
dc.description.abstractBackground: High-density lipoproteins (HDL) have atheroprotective biological properties: antioxidative, anti-apoptotic, anti-inflammatory, and they have the efflux capacity of cellular cholesterol. Plasma mRNA analysis can be used to investigate statin pleiotropy in vivo as a new analytical tool for non-invasive assessment of gene expression in vascular beds. The aim of this study was to assess the pleiotropic effects of atorvastatin in stable angina patients with highrisk values (group A) as compared with patients who had borderline and desirable HDL-cholesterol (HDL-C) values (group B). Methods: The atorvastatin therapy (20 mg/day) was given to forty-three patients with stable angina for 10 weeks. We investigated three statin pleiotropy-targeted genes: intercellular adhesion molecule-1, chemokine (C-C motif) ligand 2 and cathepsin S and assessed by gel electrophoresis gradient the effects of atorvastatin on HDL size and subclasses. Results: In group A, after therapy, HDL-C concentration was significantly increased but not in group B. Atorvastatin lowered plasma chemokine (C-C motif) ligand 2 and intercellular adhesion molecule-1 mRNA levels in both groups, but did not change the plasma cathepsin S mRNA levels. In group A only, baseline total bilirubin showed negative cor relations with the genes of cathepsin S (r=-0.506; p = 0.023) and significantly increased after therapy. Conclusions: HDL-C and bilirubin can be promising therapeutic targets in the treatment of cardiovascular diseases. Analysis of cell-free mRNA in plasma might become a useful tool for estimating statin pleiotropy.en
dc.publisherDruštvo medicinskih biohemičara Srbije, Beograd i Versita
dc.relationAd Futura - Scientific and Educational Foundation of the Republic of Slovenia
dc.rightsopenAccess
dc.sourceJournal of Medical Biochemistry
dc.subjecthigh-density lipoprotein subclassesen
dc.subjectcathepsin Sen
dc.subjectbilirubinen
dc.subjectmRNA in plasmaen
dc.subjectatorvastatinen
dc.titleThe Pleiotropic Effects of Atorvastatin on Stable Angina Patients: Evidence by Analysis of High-Density Lipoprotein Size and Subclasses, and Plasma mRNAen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractЈелић-Ивановић, Зорана; Церне, Дарко; Јуергенс, Гуентхер; Мирјанић-Aзарић, Боса; Марц, Јања; Векић, Јелена; Миливојац, Татјана; Aврам, Сања; Зељковић, Aлександра; Цорић, Јозо;
dc.citation.volume34
dc.citation.issue3
dc.citation.spage314
dc.citation.epage322
dc.citation.other34(3): 314-322
dc.citation.rankM23
dc.identifier.wos000358329200006
dc.identifier.doi10.2478/jomb-2014-0058
dc.identifier.pmid28356842
dc.identifier.scopus2-s2.0-84938368275
dc.identifier.fulltexthttp://farfar.pharmacy.bg.ac.rs//bitstream/id/1122/2430.pdf
dc.identifier.rcubconv_3348
dc.type.versionpublishedVersion


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