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dc.creatorKrstić, Marko
dc.creatorRažić, Slavica
dc.creatorĐekić, Ljiljana
dc.creatorDobričić, Vladimir
dc.creatorMomcilović, Milica A.
dc.creatorVasiljević, Dragana
dc.creatorIbrić, Svetlana
dc.date.accessioned2019-09-02T11:47:53Z
dc.date.available2019-09-02T11:47:53Z
dc.date.issued2015
dc.identifier.issn0326-2383
dc.identifier.urihttp://farfar.pharmacy.bg.ac.rs/handle/123456789/2433
dc.description.abstractThe purpose of this study was to investigate the solid self-emulsifying drug delivery system (SSEDDS), as a potential delivery system for poorly water soluble carbamazepine by application of mixture design. The self-emulsifying drug delivery system (SEDDS) was formulated using Polysorbate 80, Transcutol (R) HP and Mygliol (R) 812. The input parameters for mixture design (components of SSEDDS) were: appropriate SEDDS, carbamazepine and adsorbent, Neusilin (R) UFL2, with appropriate ranges 10-30%, 30-50% and 40-60%, respectively. The output parameters were the percentages of carbamazepine released after 10 and 30 min. The aim was to formulate SSEDDS with very fast drug release, i.e. more than 80% of carbamazepine has to be released in 30 min. Optimal formulations were examined through the dissolution test, parallel artificial membrane permeability assay (PAMPA), differential scanning calorimetry and thermal gravimetric analysis. With the obtained mixture design models, for any combination of factors ratios, it is possible to predict the profile of carbamazepine release. Optimal formulations exhibited significantly improved drug release and permeability.en
dc.publisherColegio Farmaceuticos Provincia De Buenos Aires, La Plata
dc.relationinfo:eu-repo/grantAgreement/MESTD/Technological Development (TD or TR)/34007/RS//
dc.rightsrestrictedAccess
dc.sourceLatin American Journal of Pharmacy
dc.subjectcarbamazepineen
dc.subjectmixture experimental designen
dc.subjectNeusilin (R) UFL2en
dc.subjectPAMPAen
dc.subjectSEDDSen
dc.titleApplication of a Mixture Experimental Design in the Optimization of the Formulation of Solid Self-Emulsifying Drug Delivery Systems Containing Carbamazepineen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractМомциловић, Милица A.; Крстић, Марко; Добричић, Владимир; Васиљевић, Драгана; Ђекић, Љиљана; Ибрић, Светлана; Ражић, Славица;
dc.citation.volume34
dc.citation.issue5
dc.citation.spage885
dc.citation.epage894
dc.citation.other34(5): 885-894
dc.citation.rankM23
dc.identifier.wos000358529200005
dc.identifier.scopus2-s2.0-84929628214
dc.identifier.rcubconv_3354
dc.type.versionpublishedVersion


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