Anti-Helicobacter pylori Activity of Four Alchemilla Species (Rosaceae)
Аутори
Krivokuća, MarijaNiketić, Marjan
Milenković, Marina
Golić, Nataša
Masia, Carla
Scaltrito, Maria Maddalena
Sisto, Francesca
Kundaković, Tatjana
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
The present study evaluated the anti-Helicobacter pylori activity of Alchemilla glabra Neygenf. (A. sect. Alchemilla), A. monticola Opiz (A. sect. Plicatae S.E. Frohner), A. fissa Gunther & Schummel (A. sect. Calycinae (Buser) Buser) and A. viridiflora Rothm. (A. sect. Calycinae), and identified ellagic acid and quercetin-3-O-beta-D-glucoside. Anti-H. pylori activity was tested against ten clinical isolates and one reference strain (ATCC 43504). The methanol extracts were more active than the dichloromethane and cyclohexane extracts. The ranges of concentrations were between 4 mu g/mL for methanol extracts of A. viridiflora, A. glabra and A. monticola, and 256 mu g/mL for cyclohexane extracts of A. viridiflora, A. glabra and A. fissa. The best overall activity was obtained with A. monticola extracts. No significant difference was found in the ellagic acid contents of the methanol extracts of the tested Alchemilla species (0.2-0.3 mg/mL), and anti-H. pylori activity was similar (4-32 mu... g/mL). Ellagic acid exhibited strong activity at very low concentrations (0.125-0.5 mu g/mL), while the second identified compound, quercetin-3-O-beta-D-glucoside, was also very active in concentration of 2-16 mu g/mL.
Кључне речи:
Alchemilla sp. / Ellagic acid / Helicobacter pylori / Quercetin-3-O-beta-D-glucosideИзвор:
Natural Product Communications, 2015, 10, 8, 1369-1371Издавач:
- Natural Products Inc, Westerville
Финансирање / пројекти:
- Испитивање лековитог потенцијала биљака: морфолошка, хемијска и фармаколошка карактеризација (RS-MESTD-Basic Research (BR or ON)-173021)
- Биљни и синтетички биоактивни производи новије генерације (RS-MESTD-Technological Development (TD or TR)-34012)
Напомена:
- Peer-reviewd.manuscript: http://farfar.pharmacy.bg.ac.rs/handle/123456789/3537
Институција/група
PharmacyTY - JOUR AU - Krivokuća, Marija AU - Niketić, Marjan AU - Milenković, Marina AU - Golić, Nataša AU - Masia, Carla AU - Scaltrito, Maria Maddalena AU - Sisto, Francesca AU - Kundaković, Tatjana PY - 2015 UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2436 AB - The present study evaluated the anti-Helicobacter pylori activity of Alchemilla glabra Neygenf. (A. sect. Alchemilla), A. monticola Opiz (A. sect. Plicatae S.E. Frohner), A. fissa Gunther & Schummel (A. sect. Calycinae (Buser) Buser) and A. viridiflora Rothm. (A. sect. Calycinae), and identified ellagic acid and quercetin-3-O-beta-D-glucoside. Anti-H. pylori activity was tested against ten clinical isolates and one reference strain (ATCC 43504). The methanol extracts were more active than the dichloromethane and cyclohexane extracts. The ranges of concentrations were between 4 mu g/mL for methanol extracts of A. viridiflora, A. glabra and A. monticola, and 256 mu g/mL for cyclohexane extracts of A. viridiflora, A. glabra and A. fissa. The best overall activity was obtained with A. monticola extracts. No significant difference was found in the ellagic acid contents of the methanol extracts of the tested Alchemilla species (0.2-0.3 mg/mL), and anti-H. pylori activity was similar (4-32 mu g/mL). Ellagic acid exhibited strong activity at very low concentrations (0.125-0.5 mu g/mL), while the second identified compound, quercetin-3-O-beta-D-glucoside, was also very active in concentration of 2-16 mu g/mL. PB - Natural Products Inc, Westerville T2 - Natural Product Communications T1 - Anti-Helicobacter pylori Activity of Four Alchemilla Species (Rosaceae) VL - 10 IS - 8 SP - 1369 EP - 1371 UR - https://hdl.handle.net/21.15107/rcub_farfar_2436 ER -
@article{ author = "Krivokuća, Marija and Niketić, Marjan and Milenković, Marina and Golić, Nataša and Masia, Carla and Scaltrito, Maria Maddalena and Sisto, Francesca and Kundaković, Tatjana", year = "2015", abstract = "The present study evaluated the anti-Helicobacter pylori activity of Alchemilla glabra Neygenf. (A. sect. Alchemilla), A. monticola Opiz (A. sect. Plicatae S.E. Frohner), A. fissa Gunther & Schummel (A. sect. Calycinae (Buser) Buser) and A. viridiflora Rothm. (A. sect. Calycinae), and identified ellagic acid and quercetin-3-O-beta-D-glucoside. Anti-H. pylori activity was tested against ten clinical isolates and one reference strain (ATCC 43504). The methanol extracts were more active than the dichloromethane and cyclohexane extracts. The ranges of concentrations were between 4 mu g/mL for methanol extracts of A. viridiflora, A. glabra and A. monticola, and 256 mu g/mL for cyclohexane extracts of A. viridiflora, A. glabra and A. fissa. The best overall activity was obtained with A. monticola extracts. No significant difference was found in the ellagic acid contents of the methanol extracts of the tested Alchemilla species (0.2-0.3 mg/mL), and anti-H. pylori activity was similar (4-32 mu g/mL). Ellagic acid exhibited strong activity at very low concentrations (0.125-0.5 mu g/mL), while the second identified compound, quercetin-3-O-beta-D-glucoside, was also very active in concentration of 2-16 mu g/mL.", publisher = "Natural Products Inc, Westerville", journal = "Natural Product Communications", title = "Anti-Helicobacter pylori Activity of Four Alchemilla Species (Rosaceae)", volume = "10", number = "8", pages = "1369-1371", url = "https://hdl.handle.net/21.15107/rcub_farfar_2436" }
Krivokuća, M., Niketić, M., Milenković, M., Golić, N., Masia, C., Scaltrito, M. M., Sisto, F.,& Kundaković, T.. (2015). Anti-Helicobacter pylori Activity of Four Alchemilla Species (Rosaceae). in Natural Product Communications Natural Products Inc, Westerville., 10(8), 1369-1371. https://hdl.handle.net/21.15107/rcub_farfar_2436
Krivokuća M, Niketić M, Milenković M, Golić N, Masia C, Scaltrito MM, Sisto F, Kundaković T. Anti-Helicobacter pylori Activity of Four Alchemilla Species (Rosaceae). in Natural Product Communications. 2015;10(8):1369-1371. https://hdl.handle.net/21.15107/rcub_farfar_2436 .
Krivokuća, Marija, Niketić, Marjan, Milenković, Marina, Golić, Nataša, Masia, Carla, Scaltrito, Maria Maddalena, Sisto, Francesca, Kundaković, Tatjana, "Anti-Helicobacter pylori Activity of Four Alchemilla Species (Rosaceae)" in Natural Product Communications, 10, no. 8 (2015):1369-1371, https://hdl.handle.net/21.15107/rcub_farfar_2436 .