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dc.creatorBaralić, Ivana
dc.creatorAnđelković, Marija
dc.creatorĐorđević, Brižita
dc.creatorDikić, Nenad
dc.creatorRadivojević, Nenad
dc.creatorSuzin-Živković, Violeta
dc.creatorRadojević-Skodrić, Sanja
dc.creatorPejić, Snežana
dc.date.accessioned2019-09-02T11:48:10Z
dc.date.available2019-09-02T11:48:10Z
dc.date.issued2015
dc.identifier.issn1741-427X
dc.identifier.urihttp://farfar.pharmacy.bg.ac.rs/handle/123456789/2445
dc.description.abstractThe physiologic stress induced by physical activity is reflected in immune systemperturbations, oxidative stress, muscle injury, and inflammation. We investigated the effect of astaxanthin (Asx) supplementation on salivary IgA (sIgA) and oxidative stress status in plasma, along with changes in biochemical parameters and total/differential white cell counts. Forty trained male soccer players were randomly assigned to Asx and placebo groups. Asx group was supplemented with 4mg of Asx. Saliva and blood samples were collected at the baseline and after 90 days of supplementation in preexercise conditions. We observed a rise of sIgA levels at rest after 90 days of Asx supplementation, which was accompanied with a decrease in prooxidant-antioxidant balance. The plasma muscle enzymes levels were reduced significantly by Asx supplementation and by regular training. The increase in neutrophil count and hs-CRP level was found only in placebo group, indicating a significant blunting of the systemic inflammatory response in the subjects taking Asx. This study indicates that Asx supplementation improves sIgA response and attenuates muscle damage, thus preventing inflammation induced by rigorous physical training. Our findings also point that Asx could show significant physiologic modulation in individuals with mucosal immunity impairment or under conditions of increased oxidative stress and inflammation.en
dc.publisherHindawi Publishing Corp, New York
dc.relationinfo:eu-repo/grantAgreement/MESTD/Integrated and Interdisciplinary Research (IIR or III)/46001/RS//
dc.rightsopenAccess
dc.sourceEvidence-Based Complementary and Alternative Medicine
dc.titleEffect of Astaxanthin Supplementation on Salivary IgA, Oxidative Stress, and Inflammation in Young Soccer Playersen
dc.typearticle
dc.rights.licenseBY
dcterms.abstractПејић, Снежана; Дикић, Ненад; Баралић, Ивана; Радојевић-Скодрић, Сања; Радивојевић, Ненад; Ђорђевић, Брижита; Aнђелковић, Марија; Сузин-Живковић, Виолета;
dc.citation.rankM22
dc.identifier.wos000357200400001
dc.identifier.doi10.1155/2015/783761
dc.identifier.pmid26167194
dc.identifier.scopus2-s2.0-84934344013
dc.identifier.fulltexthttp://farfar.pharmacy.bg.ac.rs//bitstream/id/1130/2443.pdf
dc.identifier.rcubconv_3076
dc.type.versionpublishedVersion


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