Alzheimer's disease (AD) is a multi factorial disease, related to the loss of neurons and synapses in cerebral cortex and subcortical structures, leading to degenerative changes and atrophy. Despite abundance of facts related to AD and its pathology, the only drugs used in the prevention and treatment are those from the cholinesterase inhibitors group. However, there is growing evidence that a non-classical therapeutic approach in the treatment of AD has beneficial effects. In this review we summarized recent literature data related to the non-classical drugs for the treatment of AD predominantly used in clinical testing, such as amyloid aggregation inhibitors, beta-sheet breakers, antioxidants, estrogens and immunotherapeutics.
TY - JOUR
AU - Bajić, Vladan
AU - Potparević, Biljana
AU - Živković, Lada
AU - Sudar, Emina
AU - Zafirović, Sonja
AU - Obradović, Milan
AU - Isenović, Esma
PY - 2015
UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2446
AB - Alzheimer's disease (AD) is a multi factorial disease, related to the loss of neurons and synapses in cerebral cortex and subcortical structures, leading to degenerative changes and atrophy. Despite abundance of facts related to AD and its pathology, the only drugs used in the prevention and treatment are those from the cholinesterase inhibitors group. However, there is growing evidence that a non-classical therapeutic approach in the treatment of AD has beneficial effects. In this review we summarized recent literature data related to the non-classical drugs for the treatment of AD predominantly used in clinical testing, such as amyloid aggregation inhibitors, beta-sheet breakers, antioxidants, estrogens and immunotherapeutics.
PB - Bentham Science Publ Ltd, Sharjah
T2 - Letters in Drug Design and Discovery
T1 - Non-Classical Therapeutic Approach in the Treatment of Alzheimer's Disease: A Mini Review
VL - 12
IS - 2
SP - 158
EP - 164
UR - https://hdl.handle.net/21.15107/rcub_vinar_398
ER -
@article{
author = "Bajić, Vladan and Potparević, Biljana and Živković, Lada and Sudar, Emina and Zafirović, Sonja and Obradović, Milan and Isenović, Esma",
year = "2015",
abstract = "Alzheimer's disease (AD) is a multi factorial disease, related to the loss of neurons and synapses in cerebral cortex and subcortical structures, leading to degenerative changes and atrophy. Despite abundance of facts related to AD and its pathology, the only drugs used in the prevention and treatment are those from the cholinesterase inhibitors group. However, there is growing evidence that a non-classical therapeutic approach in the treatment of AD has beneficial effects. In this review we summarized recent literature data related to the non-classical drugs for the treatment of AD predominantly used in clinical testing, such as amyloid aggregation inhibitors, beta-sheet breakers, antioxidants, estrogens and immunotherapeutics.",
publisher = "Bentham Science Publ Ltd, Sharjah",
journal = "Letters in Drug Design and Discovery",
title = "Non-Classical Therapeutic Approach in the Treatment of Alzheimer's Disease: A Mini Review",
volume = "12",
number = "2",
pages = "158-164",
url = "https://hdl.handle.net/21.15107/rcub_vinar_398"
}
Bajić, V., Potparević, B., Živković, L., Sudar, E., Zafirović, S., Obradović, M.,& Isenović, E.. (2015). Non-Classical Therapeutic Approach in the Treatment of Alzheimer's Disease: A Mini Review. in Letters in Drug Design and Discovery
Bentham Science Publ Ltd, Sharjah., 12(2), 158-164.
https://hdl.handle.net/21.15107/rcub_vinar_398
Bajić V, Potparević B, Živković L, Sudar E, Zafirović S, Obradović M, Isenović E. Non-Classical Therapeutic Approach in the Treatment of Alzheimer's Disease: A Mini Review. in Letters in Drug Design and Discovery. 2015;12(2):158-164.
https://hdl.handle.net/21.15107/rcub_vinar_398 .
Bajić, Vladan, Potparević, Biljana, Živković, Lada, Sudar, Emina, Zafirović, Sonja, Obradović, Milan, Isenović, Esma, "Non-Classical Therapeutic Approach in the Treatment of Alzheimer's Disease: A Mini Review" in Letters in Drug Design and Discovery, 12, no. 2 (2015):158-164,
https://hdl.handle.net/21.15107/rcub_vinar_398 .
