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dc.creatorSimić, Milena
dc.creatorStanković, Miroslava
dc.creatorMandić, Boris M.
dc.creatorTešević, Vele
dc.creatorSavić, Vladimir
dc.date.accessioned2019-09-02T11:48:17Z
dc.date.available2019-09-02T11:48:17Z
dc.date.issued2015
dc.identifier.issn0365-6233
dc.identifier.urihttps://farfar.pharmacy.bg.ac.rs/handle/123456789/2450
dc.description.abstractCytoprotective compounds such as amifostine play an important role in chemo-and radiotherapy due to their ability to reduce the side effects of these treatments. Our work was initiated with the intention to design, synthesise and test a new class of heterocyclic compounds that would have an antioxidative profile with the potential to be further developed as cytoprotective agents. The design was based on the privileged tetrahydrobenzazepine scaffold found in many natural products with a wide range of biological properties. This structure was further functionalised with moieties known to possess antioxidative features such as tertiary amine and styrene double bond. A series of eight tetrahydrobenzazepine derivatives of isoquinoline, 3,4-dihydro-beta-carboline and pyridine were synthesised employing the Heck reaction as a key transformation. Some of the prepared compounds were tested for their in vitro effects on chromosome aberrations in peripheral human lymphocytes using the cytochalasin-B blocked micronucleus (MN) assay. Three tetrahydrobenzoazepine derivatives showed significant cytoprotective properties, comparable or even better to those of the radioprotective agent amifostine.en
dc.publisherWiley-VCH Verlag GMBH, Weinheim
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/172009/RS//
dc.rightsrestrictedAccess
dc.sourceArchiv der Pharmazie
dc.subjectCytoprotectionen
dc.subjectHeterocyclesen
dc.subjectMicronucleien
dc.subjectSynthesisen
dc.subjectTetrahydrobenzazepineen
dc.titleSynthesis of Novel Tetrahydrobenzazepine Derivatives and Their Cytoprotective Effect on Human Lymphocytesen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractМандић, Борис М.; Тешевић, Веле; Савић, Владимир; Симић, Милена; Станковић, Мирослава;
dc.citation.volume348
dc.citation.issue2
dc.citation.spage100
dc.citation.epage112
dc.citation.other348(2): 100-112
dc.citation.rankM22
dc.identifier.wos000349628500003
dc.identifier.doi10.1002/ardp.201400350
dc.identifier.pmid25664628
dc.identifier.scopus2-s2.0-84922572924
dc.type.versionpublishedVersion


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Приказ основних података о документу