Recent clinical evidence suggests that the therapeutic effect of massage involves the immune system and that this can be exploited as an adjunct therapy together with standard drug-based approaches. In this study, we investigated the mechanisms behind these effects exploring the immunomodulatory function of stroking as a surrogate of massage-like therapy in mice. C57/BL6 mice were stroked daily for 8 days either with a soft brush or directly with a gloved hand and then analysed for differences in their immune repertoire compared to control non-stroked mice. Our results show that hand-but not brush-stroked mice demonstrated a significant increase in thymic and splenic T cell number (p lt 0.05; p lt 0.01). These effects were not associated with significant changes in CD4/CD8 lineage commitment or activation profile. The boosting effects on T cell repertoire of massage-like therapy were associated with a decreased noradrenergic innervation of lymphoid organs and counteracted the immun...osuppressive effect of hydrocortisone in vivo. Together our results in mice support the hypothesis that massage-like therapies might be of therapeutic value in the treatment of immunodeficiencies and related disorders and suggest a reduction of the inhibitory noradrenergic tone in lymphoid organs as one of the possible explanations for their immunomodulatory function.
TY - JOUR
AU - Major, Benjamin
AU - Rattazzi, Lorenza
AU - Brod, Samuel
AU - Pilipović, Ivan
AU - Leposavić, Gordana
AU - D'Acquisto, Fulvio
PY - 2015
UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2458
AB - Recent clinical evidence suggests that the therapeutic effect of massage involves the immune system and that this can be exploited as an adjunct therapy together with standard drug-based approaches. In this study, we investigated the mechanisms behind these effects exploring the immunomodulatory function of stroking as a surrogate of massage-like therapy in mice. C57/BL6 mice were stroked daily for 8 days either with a soft brush or directly with a gloved hand and then analysed for differences in their immune repertoire compared to control non-stroked mice. Our results show that hand-but not brush-stroked mice demonstrated a significant increase in thymic and splenic T cell number (p lt 0.05; p lt 0.01). These effects were not associated with significant changes in CD4/CD8 lineage commitment or activation profile. The boosting effects on T cell repertoire of massage-like therapy were associated with a decreased noradrenergic innervation of lymphoid organs and counteracted the immunosuppressive effect of hydrocortisone in vivo. Together our results in mice support the hypothesis that massage-like therapies might be of therapeutic value in the treatment of immunodeficiencies and related disorders and suggest a reduction of the inhibitory noradrenergic tone in lymphoid organs as one of the possible explanations for their immunomodulatory function.
PB - Nature Publishing Group, London
T2 - Scientific World Journal
T1 - Massage-like stroking boosts the immune system in mice
VL - 5
DO - 10.1038/srep10913
ER -
@article{
author = "Major, Benjamin and Rattazzi, Lorenza and Brod, Samuel and Pilipović, Ivan and Leposavić, Gordana and D'Acquisto, Fulvio",
year = "2015",
abstract = "Recent clinical evidence suggests that the therapeutic effect of massage involves the immune system and that this can be exploited as an adjunct therapy together with standard drug-based approaches. In this study, we investigated the mechanisms behind these effects exploring the immunomodulatory function of stroking as a surrogate of massage-like therapy in mice. C57/BL6 mice were stroked daily for 8 days either with a soft brush or directly with a gloved hand and then analysed for differences in their immune repertoire compared to control non-stroked mice. Our results show that hand-but not brush-stroked mice demonstrated a significant increase in thymic and splenic T cell number (p lt 0.05; p lt 0.01). These effects were not associated with significant changes in CD4/CD8 lineage commitment or activation profile. The boosting effects on T cell repertoire of massage-like therapy were associated with a decreased noradrenergic innervation of lymphoid organs and counteracted the immunosuppressive effect of hydrocortisone in vivo. Together our results in mice support the hypothesis that massage-like therapies might be of therapeutic value in the treatment of immunodeficiencies and related disorders and suggest a reduction of the inhibitory noradrenergic tone in lymphoid organs as one of the possible explanations for their immunomodulatory function.",
publisher = "Nature Publishing Group, London",
journal = "Scientific World Journal",
title = "Massage-like stroking boosts the immune system in mice",
volume = "5",
doi = "10.1038/srep10913"
}
Major, B., Rattazzi, L., Brod, S., Pilipović, I., Leposavić, G.,& D'Acquisto, F.. (2015). Massage-like stroking boosts the immune system in mice. in Scientific World Journal
Nature Publishing Group, London., 5.
https://doi.org/10.1038/srep10913
Major B, Rattazzi L, Brod S, Pilipović I, Leposavić G, D'Acquisto F. Massage-like stroking boosts the immune system in mice. in Scientific World Journal. 2015;5.
doi:10.1038/srep10913 .
Major, Benjamin, Rattazzi, Lorenza, Brod, Samuel, Pilipović, Ivan, Leposavić, Gordana, D'Acquisto, Fulvio, "Massage-like stroking boosts the immune system in mice" in Scientific World Journal, 5 (2015),
https://doi.org/10.1038/srep10913 . .
