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dc.creatorMajor, Benjamin
dc.creatorRattazzi, Lorenza
dc.creatorBrod, Samuel
dc.creatorPilipović, Ivan
dc.creatorLeposavić, Gordana
dc.creatorD'Acquisto, Fulvio
dc.date.accessioned2019-09-02T11:48:30Z
dc.date.available2019-09-02T11:48:30Z
dc.date.issued2015
dc.identifier.issn2045-2322
dc.identifier.urihttp://farfar.pharmacy.bg.ac.rs/handle/123456789/2458
dc.description.abstractRecent clinical evidence suggests that the therapeutic effect of massage involves the immune system and that this can be exploited as an adjunct therapy together with standard drug-based approaches. In this study, we investigated the mechanisms behind these effects exploring the immunomodulatory function of stroking as a surrogate of massage-like therapy in mice. C57/BL6 mice were stroked daily for 8 days either with a soft brush or directly with a gloved hand and then analysed for differences in their immune repertoire compared to control non-stroked mice. Our results show that hand-but not brush-stroked mice demonstrated a significant increase in thymic and splenic T cell number (p lt 0.05; p lt 0.01). These effects were not associated with significant changes in CD4/CD8 lineage commitment or activation profile. The boosting effects on T cell repertoire of massage-like therapy were associated with a decreased noradrenergic innervation of lymphoid organs and counteracted the immunosuppressive effect of hydrocortisone in vivo. Together our results in mice support the hypothesis that massage-like therapies might be of therapeutic value in the treatment of immunodeficiencies and related disorders and suggest a reduction of the inhibitory noradrenergic tone in lymphoid organs as one of the possible explanations for their immunomodulatory function.en
dc.publisherNature Publishing Group, London
dc.rightsopenAccess
dc.sourceScientific World Journal
dc.titleMassage-like stroking boosts the immune system in miceen
dc.typearticle
dc.rights.licenseBY
dcterms.abstractМајор, Бењамин; Пилиповић, Иван; Лепосавић, Гордана; Д'Aцqуисто, Фулвио; Раттаззи, Лоренза; Брод, Самуел;
dc.citation.volume5
dc.citation.other5: -
dc.citation.rankM21
dc.identifier.wos000355864900001
dc.identifier.doi10.1038/srep10913
dc.identifier.pmid26046935
dc.identifier.scopus2-s2.0-84930620475
dc.identifier.fulltexthttp://farfar.pharmacy.bg.ac.rs//bitstream/id/1136/2456.pdf
dc.identifier.rcubconv_3325
dc.type.versionpublishedVersion


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