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dc.creatorMarinko, Marija
dc.creatorNovaković, Aleksandra
dc.creatorNenezić, Dragoslav
dc.creatorStojanović, Ivan
dc.creatorMilojević, Predrag
dc.creatorJović, Miomir
dc.creatorUgrešić, Nenad
dc.creatorKanjuh, Vladimir
dc.creatorYang, Qin
dc.creatorHe, Guo-Wei
dc.date.accessioned2019-09-02T11:48:33Z
dc.date.available2019-09-02T11:48:33Z
dc.date.issued2015
dc.identifier.issn1347-8613
dc.identifier.urihttps://farfar.pharmacy.bg.ac.rs/handle/123456789/2461
dc.description.abstractAs we previously demonstrated the role of different K+ channels in the action of nicorandil on human saphenous vein (HSV) and human internal mammary artery (HIMA), this study aimed to analyse the contribution of the cGMP pathway in nicorandil-induced vasorelaxation and to determine the involvement of cGMP in the K+ channel-activating effect of nicorandil. An inhibitor of soluble guanylate cyclase (GC), ODQ, significantly inhibited nicorandil-induced relaxation, while ODQ plus glibenclamide, a selective ATP-sensitive K+ (KATP) channel inhibitor, produced a further inhibition of both vessels. In HSV, ODQ in combination with 4-aminopyridine, a blocker of voltage-gated K+ (K-V) channels, did not modify the concentration-response to nicorandil compared with ODQ, whereas in HIMA, ODQ plus iberiotoxin, a selective blocker of large-conductance Ca2+-activated K+ (BKCa) channels, produced greater inhibition than ODQ alone. We showed that the cGMP pathway plays a significant role in the vasorelaxant effect of nicorandil on HSV and HIMA. It seems that nicorandil directly opens KATP channels in both vessels and BKCa channels in HIMA, although it is possible that stimulation of GC contributes to KATP channels activation in HIMA. Contrary, the activation of K-V channels in HSV is probably due to GC activation and increased levels of cGMP.en
dc.publisherJapanese Pharmacological Soc, Kyoto
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/175088/RS//
dc.rightsopenAccess
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/
dc.sourceJournal of Pharmacological Sciences
dc.subjectNicorandilen
dc.subjectCyclic GMPen
dc.subjectK channelen
dc.subjectVasorelaxationen
dc.subjectHuman bypass graftsen
dc.titleNicorandil directly and cyclic GMP-dependently opens K+ channels in human bypass graftsen
dc.typearticle
dc.rights.licenseBY-NC-ND
dcterms.abstractНенезић, Драгослав; Јовић, Миомир; Стојановић, Иван; Милојевић, Предраг; Маринко, Марија; Хе, Гуо-Wеи; Кањух, Владимир; Yанг, Qин; Новаковић, Aлександра; Угрешић, Ненад;
dc.citation.volume128
dc.citation.issue2
dc.citation.spage59
dc.citation.epage64
dc.citation.other128(2): 59-64
dc.citation.rankM22
dc.identifier.wos000357472000001
dc.identifier.doi10.1016/j.jphs.2015.03.003
dc.identifier.pmid25850381
dc.identifier.scopus2-s2.0-84937396257
dc.identifier.fulltexthttps://farfar.pharmacy.bg.ac.rs//bitstream/id/1139/2459.pdf
dc.identifier.rcubconv_3341
dc.type.versionpublishedVersion


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