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dc.creatorNovaković, Radmila
dc.creatorRadunović, Nebojša
dc.creatorMarković-Lipkovski, Jasmina
dc.creatorCirović, S.
dc.creatorBeleslin-Cokić, Bojana B.
dc.creatorIlić, B.
dc.creatorIvković, Branka
dc.creatorHeinle, Helmut
dc.creatorŽivanović, Vladimir
dc.creatorGojković-Bukarica, Ljiljana
dc.date.accessioned2019-09-02T11:48:33Z
dc.date.available2019-09-02T11:48:33Z
dc.date.issued2015
dc.identifier.issn1360-9947
dc.identifier.urihttps://farfar.pharmacy.bg.ac.rs/handle/123456789/2462
dc.description.abstractThe ideal agent for prevention and treatment of uterine abnormal contractility has not been found. The polyphenol resveratrol possesses a wide spectrum of pharmacologic properties, but its influence on the contractility of human myometrium is not defined. The present study evaluated the effect of resveratrol on the oxytocin-induced contractions of human term pregnant myometrium in vitro and the contribution of different K+ channels to resveratrol action. Resveratrol induced a concentration-dependent relaxation of myometrium contractions (pD(2) value and maximal responses were 4.52 and 82.25%, respectively). Glibenclamide, a selective blocker of ATP-sensitive (K-ATP), iberiotoxin, a selective blockers of big-calcium sensitive (BKCa) and 4-aminopiridine, a non-selective blocker of voltage-sensitive (Kv) channels induced a significant shift to the right of the concentration-response curves of resveratrol. Inhibition achieved by 0.1 mM resveratrol was insensitive to all K+ channel blockers. A K+ channel opener, pinacidil, inhibited oxytocin-induced contractions of pregnant myometrium with comparable potency and efficacy to resveratrol (pD(2) values and maximal relaxation were 4.52 and 83.67%, respectively). Based on K+ channel opener/blocker affinities, it appears that the inhibitory response of resveratrol involves different myometrial K+ channels. When applied in high concentrations, resveratrol has an additional K+-channel-independent mechanism(s) of action. Furthermore, immunohistochemistry staining and western blot analyses detected the presence and distribution of K-ATP, BKCa and Kv channel proteins in pregnant myometrium.en
dc.publisherOxford Univ Press, Oxford
dc.relationinfo:eu-repo/grantAgreement/MESTD/Technological Development (TD or TR)/31020/RS//
dc.rightsopenAccess
dc.sourceMolecular Human Reproduction
dc.subjectcontractionen
dc.subjectK+- channelsen
dc.subjectmyometriumen
dc.subjectpregnancyen
dc.subjectresveratrolen
dc.titleEffects of the polyphenol resveratrol on contractility of human term pregnant myometriumen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractИвковић, Бранка; Новаковић, Радмила; Илић, Б.; Цировић, С.; Радуновић, Небојша; Хеинле, Хелмут; Марковић-Липковски, Јасмина; Белеслин-Цокић, Бојана Б.; Живановић, Владимир; Гојковић-Букарица, Љиљана;
dc.citation.volume21
dc.citation.issue6
dc.citation.spage545
dc.citation.epage551
dc.citation.other21(6): 545-551
dc.citation.rankM21
dc.identifier.wos000356261000006
dc.identifier.doi10.1093/molehr/gav011
dc.identifier.pmid25750187
dc.identifier.scopus2-s2.0-84942107911
dc.identifier.fulltexthttps://farfar.pharmacy.bg.ac.rs//bitstream/id/1141/2460.pdf
dc.type.versionpublishedVersion


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