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Circulating resistin protein and mRNA concentrations and clinical severity of coronary artery disease

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2015
2463.pdf (118.5Kb)
Authors
Joksić, Jelena
Sopić, Miron
Spasojević-Kalimanovska, Vesna
Kalimanovska-Oštrić, Dimitra
Anđelković, Kristina
Jelić-Ivanović, Zorana
Article (Published version)
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Abstract
Introduction: Previous studies have implicated a strong link between circulating plasma resistin and coronary artery disease (CAD). The aim of this study was to evaluate the differences in peripheral blood mononuclear cells (PBMC) resistin mRNA and its plasma protein concentrations between the patients with CAD of different clinical severity. Material and methods: This study included 33 healthy subjects as the control group (CG) and 77 patients requiring coronary angiography. Of the latter 30 was CAD negative whereas 47 were CAD positive [18 with stable angina pectoris (SAP) and 29 with acute coronary syndrome (ACS)]. Circulating resistin was measured by ELISA; PBMC resistin mRNA was determined by real-time PCR. Results: Resistin protein was significantly higher in the ACS group compared to the CG (P = 0.001) and the CAD negative group (P = 0.018). Resistin mRNA expression did not vary across the study groups, despite the positive correlation seen with plasma resistin (rho = 0.305, P =... 0.008). In patients, plasma resistin and PBMC resistin mRNA negatively correlated with HDL-C (rho = -0.404, P lt 0.001 and rho = -0.257, P = 0.032, respectively). Furthermore, the highest plasma resistin tertile showed the lowest HDL-C (P = 0.006). Plasma resistin was positively associated with serum creatinine (rho = 0.353, P = 0.002). Conclusion: Significant increase of plasma resistin in patients with ACS compared to CG and CAD negative patients was observed. Despite no change in PBMC resistin mRNA in different disease conditions a positive association between resistin mRNA and resistin plasma protein was evident. Both plasma resistin and PBMC resistin mRNA were negatively associated with plasma HDL-C, and plasma resistin positively with serum creatinine.

Keywords:
resistin, human / gene expression / coronary artery disease / acute coronary syndrome
Source:
Biochemia Medica, 2015, 25, 2, 242-251
Publisher:
  • Croatian Soc Medical Biochemistry & Laboratory Medicine, Zagreb
Projects:
  • Interactive role of dyslipidemia, oxidative stress and inflammation in atherosclerosis and other diseases: genetic and biochemical markers (RS-175035)

DOI: 10.11613/BM.2015.025

ISSN: 1330-0962

PubMed: 26110037

WoS: 000356588100012

Scopus: 2-s2.0-84930444382
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URI
http://farfar.pharmacy.bg.ac.rs/handle/123456789/2465
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  • Radovi istraživača / Researchers’ publications
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Pharmacy

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