ФарФаР - Фармацеутски факултет, репозиторијум
Универзитет у Београду, Фармацеутски факултет
    • English
    • Српски
    • Српски (Serbia)
  • Српски (ћирилица) 
    • Енглески
    • Српски (ћирилица)
    • Српски (латиница)
  • Пријава
Преглед рада 
  •   ФарФаР - Фармацеутски факултет, репозиторијум
  • Pharmacy
  • Radovi istraživača / Researchers’ publications
  • Преглед рада
  •   ФарФаР - Фармацеутски факултет, репозиторијум
  • Pharmacy
  • Radovi istraživača / Researchers’ publications
  • Преглед рада
JavaScript is disabled for your browser. Some features of this site may not work without it.

Circulating resistin protein and mRNA concentrations and clinical severity of coronary artery disease

Thumbnail
2015
2463.pdf (118.5Kb)
Аутори
Joksić, Jelena
Sopić, Miron
Spasojević-Kalimanovska, Vesna
Kalimanovska-Oštrić, Dimitra
Anđelković, Kristina
Jelić-Ivanović, Zorana
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документу
Апстракт
Introduction: Previous studies have implicated a strong link between circulating plasma resistin and coronary artery disease (CAD). The aim of this study was to evaluate the differences in peripheral blood mononuclear cells (PBMC) resistin mRNA and its plasma protein concentrations between the patients with CAD of different clinical severity. Material and methods: This study included 33 healthy subjects as the control group (CG) and 77 patients requiring coronary angiography. Of the latter 30 was CAD negative whereas 47 were CAD positive [18 with stable angina pectoris (SAP) and 29 with acute coronary syndrome (ACS)]. Circulating resistin was measured by ELISA; PBMC resistin mRNA was determined by real-time PCR. Results: Resistin protein was significantly higher in the ACS group compared to the CG (P = 0.001) and the CAD negative group (P = 0.018). Resistin mRNA expression did not vary across the study groups, despite the positive correlation seen with plasma resistin (rho = 0.305, P =... 0.008). In patients, plasma resistin and PBMC resistin mRNA negatively correlated with HDL-C (rho = -0.404, P lt 0.001 and rho = -0.257, P = 0.032, respectively). Furthermore, the highest plasma resistin tertile showed the lowest HDL-C (P = 0.006). Plasma resistin was positively associated with serum creatinine (rho = 0.353, P = 0.002). Conclusion: Significant increase of plasma resistin in patients with ACS compared to CG and CAD negative patients was observed. Despite no change in PBMC resistin mRNA in different disease conditions a positive association between resistin mRNA and resistin plasma protein was evident. Both plasma resistin and PBMC resistin mRNA were negatively associated with plasma HDL-C, and plasma resistin positively with serum creatinine.

Кључне речи:
resistin, human / gene expression / coronary artery disease / acute coronary syndrome
Извор:
Biochemia Medica, 2015, 25, 2, 242-251
Издавач:
  • Croatian Soc Medical Biochemistry & Laboratory Medicine, Zagreb
Пројекти:
  • Интерактивна улога дислипидемије, оксидативног стреса и инфламације у атеросклерози и другим болестима: генетички и биохемијски маркери (RS-175035)

DOI: 10.11613/BM.2015.025

ISSN: 1330-0962

PubMed: 26110037

WoS: 000356588100012

Scopus: 2-s2.0-84930444382
[ Google Scholar ]
12
12
URI
http://farfar.pharmacy.bg.ac.rs/handle/123456789/2465
Колекције
  • Radovi istraživača / Researchers’ publications
Институција
Pharmacy

DSpace software copyright © 2002-2015  DuraSpace
О ФарФаР-у | Пошаљите запажања

OpenAIRERCUB
 

 

Комплетан репозиторијумИнституцијеАуториНасловиТемеОва институцијаАуториНасловиТеме

Статистика

Преглед статистика

DSpace software copyright © 2002-2015  DuraSpace
О ФарФаР-у | Пошаљите запажања

OpenAIRERCUB